Genetic and fluorescence studies of affinity maturation in related antibodies

Molecular Immunology

Volumn 43, Issue 7, 2006, Pages 812-821

  Pauyo, Thierry ^a   Hilinski, Gerard J ^a,b   Chiu, Philip T ^a,c   Hansen, David E ^a   Choi, Yoon J ^a   Ratner, David I ^a   Shah Mahoney, Nalini ^a   Southern, Cathrine A ^a,d   O'Hara, Patricia B ^a  

^a AMHERST COLLEGE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Northwestern University   (United States)

^d Department of Biology   (United States)

Author keywords

Fluorescence anisotropy; Fluorescence quenching; Germ line genes; Monoclonal antibodies

Indexed keywords

AMINO ACID; ANTIBODY; CATALYTIC ANTIBODY; DIKETONE; ENZYME ANTIBODY; FRUCTOSE BISPHOSPHATE ALDOLASE; GENE PRODUCT; HAPTEN; MONOCLONAL ANTIBODY; NAPHTHALENE DERIVATIVE; PRODAN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANISOTROPY; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; ENTHALPY; ENTROPY; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE ANALYSIS; FLUORESCENT ANTIBODY TECHNIQUE; FLUOROMETRY; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GERM LINE; IMMUNE RESPONSE; IMMUNOGENETICS; INOCULATION; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOTOCHEMICAL QUENCHING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; STEADY STATE;

2-NAPHTHYLAMINE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, CATALYTIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY REACTIONS; FRUCTOSE-BISPHOSPHATE ALDOLASE; HAPTENS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MOLECULAR SEQUENCE DATA; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

ANIMALIA; MURINAE;

EID: 29144533923     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.07.001     Document Type: Article

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