Aged rat myocardium exhibits normal adenosine receptor-mediated bradycardia and coronary vasodilation but increased adenosine agonist-mediated cardioprotection

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 60, Issue 11, 2005, Pages 1399-1404

  Kristo, Gentian ^a   Yoshimura, Yukihiro ^a   Keith, Byron J ^a   Mentzer Jr , Robert M ^a   Lasley, Robert D ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [7 [[1 [(3 CHLORO 2 THIENYL)METHYL]PROPYL]AMINO] 3H IMIDAZO[4,5 B]PYRIDIN 3 YL] N ETHYL 2,3 DIHYDROXYCYCLOPENTANECARBOXAMIDE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CORONARY VASCULAR RESISTANCE; FEMALE; HEART INFARCTION SIZE; HEART MUSCLE; HEART PROTECTION; HEART RATE; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION;

ANIMALIA;

EID: 29144467628     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/60.11.1399     Document Type: Article

References (48)

1. Lakatta EG, Yin FC. Myocardial aging: functional alterations and related cellular mechanisms. Am J Physiol. 1982;242:927-941.
2. Vestal RE, Wood AJ, Shand D. Reduced β-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther. 1979;26:181-186.
3. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation. 1993;88:77-81.
4. Hinschen AK, Rose'Meyer RB, Headrick JP. Age-related changes in adenosine-mediated relaxation of coronary and aortic smooth muscle. Am J Physiol (Heart Circ Physiol). 2001;280:2380-2389.
5. Tresch D, McGough M. Heart failure with normal systolic function: a common disorder in older people. J Am Geriatr Soc. 1995;43:1035-1042.
6. Shryock JC, Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am J Cardiol. 1997;79:2-10.
7. Headrick JP. Impact of aging on adenosine levels, A1/A2 responses, arrhythmogenesis, and energy metabolism in rat heart. Am J Physiol (Heart Circ Physiol). 1996;270:897-906.
8. Cai G, Wang HY, Gao E, et al. Reduced adenosine A(1) receptor and G(alpha) protein coupling in rat ventricular myocardium during aging. Circ Res. 1997;81:1065-1067.
9. Rose'Meyer RB, Harden FA, Varela JI, Harrison GJ, Willis RJ. Age-related changes in adenosine in rat coronary resistance vessels. Gen Pharmacol. 1999;32:35-40.
10. Xu J, Gao F, Ma XL, et al. Effect of aging on the negative chronotropic and anti-beta-adrenergic actions of adenosine in the rat heart. J Cardiovasc Pharmacol 1999;34:904-912.
11. Romano FD, Dobson JG Jr. Adenosine attenuation of isoproterenol- stimulated adenylyl cyclase activity is enhanced with aging in the adult heart. Life Sci. 1996;58:493-502.
12. Kapicka CL, Montamat SC, Mudumbi RV, Jacks SM, Olson RD, Vestal RE. Effects of cyclopentyladenosine on isoproterenol response in adult and senescent cardiac tissue from Fischer 344 rats. J Pharmacol Exp Ther. 2000;293:599-606.
13. Hinschen AK, Rose'Meyer RB, Headrick JP. Age-related changes in A(1)-adenosine receptor-mediated bradycardia. Am J Physiol (Heart Circ Physiol). 2000;278:789-795.
14. Lakatta EG, Sollott SJ. The "heartbreak" of older age. Mol Interv. 2002;2:431-446.
15. Rebrin I, Kamzalov S, Sohal R. Effects of age and caloric restriction on glutathione redox state in mice. Free Radic Biol Meet. 2003;35:626-635.
16. Hano O, Bogdanov KY, Sakai M, Danziger RG, Spurgeon HA, Lakatta EG. Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging. Am J Physiol. 1995;269: H1607-H1612.
17. Jahangir A, Ozcan C, Holmuhamedov EL, Terzic A. Increased calcium vulnerability of senescent cardiac mitochondria: protective role for a mitochondrial potassium channel opener. Mech Ageing Dev. 2001;122:1073-1086.
18. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure. J Mol Cell Cardiol. 2001;33:1065-1089.
19. Boucher F, Tanguy S, Toufektsian MC, et al. Age-dependent changes in myocardial susceptibility to zero flow ischemia and reperfusion in isolated perfused rat hearts: relation to antioxidant status. Mech Ageing Dev. 1998;103:301-316.
20. Lesnefsky EJ, Gall DS, Whittingham TS, Lust WD. Aging increases ischemia-reperfusion injury in the isolated buffer-perfused heart. J Lab Clin Med. 1994;124:843-851.
21. Headrick JP. Aging impairs functional, metabolic and ionic recovery from ischaemia-reperfusion and hypoxia-reoxygenation. J Mol Cell Cardiol. 1998;30:1415-1430.
22. Tani M, Suganuma Y, Hasegawa H, et al. Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts. Circulation. 1997;95:2559-2566.
23. Leichtweis S, Leeuwenburgh C, Bejma J, Ji LL. Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: role of glutathione. Mech Age Dev. 2001;122:503-518.
24. Liu P, Xu B, Cavalieri TA, Hock CE. Age-related difference in myocardial function and inflammation in a rat model of myocardial ischemia-reperfusion. Cardiovasc Res. 2002;56:443-453.
25. Headrick JP, Willems L, Ashton KJ, Holmgren K, Peart J, Matherne GP. Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression. J Physiol. 2003;549:823-833.
26. Liu P, Xu B, Cavalieri TA, Hock CE. Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium after MI/R. Am J Physiol (Heart Circ Physiol). 2004;287:2719-2727.
27. Willems L, Zatta A, Holmgren K, Ashton KJ, Headrick JP. Age-related changes in ischemic tolerance in male and female mouse hearts. J Mol Cell Cardiol. 2005;38:245-256.
28. Schulman D, Latchman DS, Yellon DM. Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury. Am J Physiol (Heart Circ Physiol). 2001;281:1630-1636.
29. Abete P, Ferrara N, Cioppa A, et al. Preconditioning does not prevent postischemic dysfunction in aging heart. J Am Coll Cardiol. 1996;27:1777-1786.
30. Abete P, Testa G, Ferrara N, et al. Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats. Am J Physiol (Heart Circ Physiol). 2002;282:1978-1987.
31. Lipman RD, Chrisp CE, Hazzard DG, Bronson RT. Pathologic characterization of brown Norway, brown Norway × Fischer 344, and Fischer 344 × brown Norway rats with relation to age. J Gerontol A Biol Sci Med Sci. 1996;51A:54-59.
32. Smith GS, Walford RL, Mickey MR. Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J Natl Cancer Inst. 1967;50:1195-1213.
33. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J Gerontol A Biol Sci Med Sci. 1999;54A:492-501.
34. 2 receptor agonist and cardioprotective. Drug Dev Res. 1998;45:30-43.
35. 2 responses, arrhythmogenesis, and energy metabolism in rat heart. Am J Physiol. 1996;270:H897-H906.
36. Gao F, Christopher TA, Lopez BL, Friedman E, Cai G, Ma XL. Mechanism of decreased adenosine protection in reperfusion injury of aging rats. Am J Physiol. (Heart Circ Physiol). 2000;279:329-338.
37. Khan AS, Lynch CD, Sane DC, Willingham MC, Sonntag WE. Growth hormone increases regional coronary blood flow and capillary density in aged rats. J Gerontol A Biol Sci Med Sci. 2001;56A:364-371.
38. Kristo G, Yoshimura Y, Keith BJ, et al. The adenosine A1/A2A receptor agonist AMP579 induces both acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol (Heart Circ Physiol.) 2004;287:H2746-H2753.
39. Feoktistov I, Biaggioni I. Adenosine A2B receptors. Pharmacol Rev. 1997;49:381-402.
40. Raya TE, Gaballa M, Anderson P, Goldman S. Left ventricular function and remodeling after myocardial infarction in aging rats. Am J Physiol. 1997;273:2652-2658.
41. Fenton RA, Dickson EW, Meyer TE, Dobson JG. Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart. J Mol Cell Cardiol. 2000;32:1371-1375.
42. Sniecinski R, Liu H. Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium. Anesthesiology. 2004;100:589-597.
43. Reid EA, Kristo G, Yoshimura Y, et al. In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling. Am J Physiol (Heart Circ Physiol). 2005;288:H2253-H2259.
44. Mubagwa K, Flameng W. Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc Res. 2001;52:25-39.
45. Przyklenk K, Li G, Whittaker P. No loss in the in vivo efficacy of ischemic preconditioning in middle-aged and old rabbits. J Am Coll Cardiol. 2001;38:1741-1747.
46. Przyklenk K, Li G, Simkhovich BZ, Kloner RA. Mechanisms of myocardial ischemic preconditioning are age related: PKC- does not play a requisite role in old rabbits. J Appl Physiol. 2003;95:2563-2569.
47. Kloner RA, Poole K, Shook T, Przyklenk K, Perritt K, Cannon CP. Comparison of acute myocardial infarct size in patients > or = 65 years versus < 65 years in the prethrombolytic period versus the thrombolytic period. Am J Cardiol. 2002;89:1291-1293.
48. Kloner RA, Przyklenk K, Shook T, Cannon CP. Protection conferred by preinfarct angina is manifest in the aged heart: evidence from the TIMI 4 trial. J Thromb Thrombolysis. 1998;6:89-92.