Effects of cyclopentyladenosine on isoproterenol response in adult and senescent cardiac tissue from Fischer 344 rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 2, 2000, Pages 599-606

  Kapicka, Chris L ^a,c   Montamat, Stephen C ^b,c   Mudumbi, Ramagopal V ^b,c   Jacks, Shelley M ^d   Olson, Richard D ^b,c,d   Vestal, Robert E ^b,c,d  

^a NORTHWEST NAZARENE UNIVERSITY   (United States)

^b Boise VA Medical Center   (United States)

^c St Luke's Mountain States Tumor Institute   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; CYANOIODOPINDOLOL; CYCLOPENTYLADENOSINE; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOSE RESPONSE; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE WALL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; SENESCENCE; TISSUE SPECIFICITY;

ADENOSINE; ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; AGING; ANIMALS; CARDIOTONIC AGENTS; ELECTRIC STIMULATION; HEART; HEART ATRIA; HEART VENTRICLES; ISOPROTERENOL; MYOCARDIAL CONTRACTION; MYOCARDIUM; RADIOLIGAND ASSAY; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, PURINERGIC P1; XANTHINES;

EID: 0034012344     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Bergmeyer HU (1983) Methods of Enzymatic Analysis, vol 2, 3rd ed., Verlag Chemie, Deerfield Beach, FL.
2. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Cai G, Wang HY, Gao E, Hurwitz J, Snyder DL, Pelleg A, Roberts J and Friedman E (1997) Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging. Circ Res 81:1065-1071.
4. De Tata V, Gori Z and Bergamini E (1985) Changes in 5′ nucleotidase and adenosine deaminase distribution across the rat left ventricle wall during growth and aging. Exp Gerontol 20:47-51
5. Dobson JG Jr (1983) Adenosine reduces catecholamine contractile responses in oxygenated and hypoxic atria. Am J Physiol 245:H468-H474.
6. Dobson JG Jr and Fenton RA (1993) Adenosine inhibition of β-adrenergic induced responses in aged hearts. Am J Physiol 265:H494-H503.
7. Dobson JG Jr, Fenton RA and Romano FD (1990) Increased myocardial adenosine production and reduction of beta-adrenergic contractile response in aged hearts. Circ Res 66:1381-1390.
8. Dobson JG Jr, Ordway RW and Fenton RA (1986) Endogenous adenosine inhibits catecholamine contractile responses in normoxic hearts. Am J Physiol 251:H455-H462.
9. 1 adenosine receptors in Sf9 cell membranes with recombinant G proteins of defined composition. Mol Pharmacol 50: 1587-1595.
10. 1 receptor function in the rat heart. J Mol Cell Cardiol 29:593-602.
11. Guarnieri T, Filburn CR, Zitnik G, Roth GS and Lakatta EG, (1980) Contractile and biochemical correlates of β-adrenergic stimulation of the aged heart. Am J Physiol 239:H501-H508.
12. Hazzard DG, Bronson RT, McClearn GE and Strong R (1992) Selection of an appropriate animal model to study the aging processes with special emphasis on the use of rat strains. J Gerontol 47:B63-B64.
13. 1-adenosine receptor. J Biol Chem 269:32077-32084.
14. 1-receptors by G proteins in rat ventricular myocytes. Am J Physiol 259:H820-H826.
15. Lakatta EG and Yin FC (1982) Myocardial aging: Functional alterations and related cellular mechanisms. Am J Physiol 242:H927-H941.
16. Londos C, Cooper DM, Schlegel W and Rodbell M (1978) Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: Basis for actions of adenosine and methylzanthines on cyclic AMP production and lipolysis. Proc Natl Acad Sci USA 75:5362-5366.
17. Londos C, Cooper DM and Wolff J (1980) Subclasses of external adenosine receptors. Proc Natl Acad Sci USA 77:2551-2554.
18. Miyamoto A, Kawana S, Kimura H and Ohshika H (1994) Impaired expression of Gs alpha protein mRNA in rat ventricular myocardium with aging. Eur J Pharmacol 266:147-154.
19. Miyatake K, Okamoto M, Kinoshita N, Owa M, Nakasone I, Sakakibara H and Nimura Y (1984) Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. Am J Cardiol 53:586-589.
20. 1 receptor activation: Direct effects on chronotropic and inotropic function in the Fischer 344 rat. J Gerontol 51A:B239-B246.
21. 1 receptor agonist, J Gerontol 50A:B351-B357.
22. o. J Biol Chem 266:22285-22289.
23. Musser B, Morgan ME, Lied M, Murray TF, Linden J and Vestal RE (1993) Species comparison of adenosine and β-adrenoceptors in mammalian atrial and ventricular myocardium. Eur J Pharmacol 246:105-111.
24. National Research Council (1981) Committee on Animal Models for Research on Aging: Mammalian Models for Research for Aging. National Academy Press, Washington, DC.
25. Newman WH, Lee JT Jr and Webb JG (1989) Persistent desensitization of the heart to the inotropic action of isoproterenol by adenosine. Res Commun Chem Pathol Pharmacol 66:233-254.
26. Pan HY, Hoffman BB, Pershe RA and Blaschke TF (1986) Decline in beta adrenergic receptor-mediated vascular relaxation with aging in human. J Pharmacol Exp Ther 239:802-807.
27. Romano FD and Dobson JG Jr (1996) Adenosine attenuation of isoproterenol-stimulated adenylyl cyclase activity is enhanced with aging in the adult heart. Life Sci 58:493-502.
28. Salomon Y (1979) Adenylate cyclase assay. Adv Cyclic Nucleotide Res 10:35-55.
29. Sartori M, Quinones M and Kuo L (1987) Relation of Doppler-derived left ventricular filling parameters to age and radius/thickness ratio in normal and pathological states. Am J Cardiol 59:1179-1182.
30. Scarpace PJ (1990) Forskolin activation of adenylyl cyclase in rate myocardium with age: Effects of guanine nucleotide analogs. Mech Ageing Dev 52:169-178.
31. Shu Y and Scarpace PJ (1994) Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging. J Cardiovasc Pharmacol 23:188-193.
32. van Calker D, Müller M and Hamprecht B (1979) Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33:999-1005.
33. Vestal RE, Wood AJ and Shand D (1979) Reduced β-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 26:181-186.
34. + channel is stimulated by three distinct Gi α-subunits. Nature (Lond) 336:680-682.