Pharmacological characterization of AMP 579, a novel adenosine A1/A2 receptor agonist and cardioprotective

Drug Development Research

Volumn 45, Issue 1, 1998, Pages 30-43

  Merkel, Linda ^a   Rojas, Camilo J ^a   Jarvis, Michael F ^a,b   Cox, Bryan F ^a,b   Fink, Cynthia ^a,c   Smits, Glenn J ^a,d   Spada, Alfred P ^a   Perrone, Mark H ^a   Clark, Kenneth L ^a  

^a SANOFI   (France)

^b ABBOTT LABORATORIES   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d BIOGEN   (United States)

Author keywords

Adenosine; Cardioprotection; Free fatty acids; Ischemia reperfusion; Lipolysis

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [7 [[2 (3 CHLORO 2 THIENYL) 1 METHYLPROPYL]AMINO] 3H IMIDAZO[4,5 B] PYRIDYL 3 YL]CYCLOPENTANE CARBOXAMIDE; 6 N (2 HYDROXYCYCLOPENTYL)ADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR AGONIST; CYCLOHEXYLADENOSINE; CYCLOPENTANE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INTRAVENOUS DRUG ADMINISTRATION; LIPOLYSIS; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; REPERFUSION INJURY; VASODILATATION;

EID: 0032444747     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199809)45:1<30::AID-DDR5>3.0.CO;2-5     Document Type: Article

References (9)

1. Auchampach JA, Gross GJ (1993): Aclenosine-A(1) receptors, K(ATP) channels and ischemie preconditioning in dog. Am J Physiol 264:111327-1336.
2. Auchampach JA, Rizvi A, Qiu Y, Tang XL, Maldonado C, Teschner S, Bolli R (1997): Selective activation of A3 adenosine receptors with NG-(3-iodobenzyl) adenosine-5′-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circ Res 80:800-809.
3. Baxter GF, Yellon DM (1997): Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit. J Cardiovasc Pharmacol 29:631-638.
4. Boachie-Ansah G, Kane KA, Parratt JR (1993): Is adenosine an endogenous myocardial protective (antiarrhythmic) substance under conditions of ischemia? Cardiovasc Res 27:77-83.
5. Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-245.
6. Bullough DA, Magill M, Firestein GS, Mullane KM (1995): Adenosine activates AZ receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes. J Iinmunol 155:2579-2586.
7. 1 receptors. J Pharmacol Exp Ther 244:478-484.
8. 2a-mediated vasodilation in porcine coronary arteries. Pharmacol Res 35:123-128.
9. - generation, respectively. J Clin Invest 85:1150-1157.