Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells

Journal of Immunology

Volumn 175, Issue 12, 2005, Pages 7848-7854

  Kovacs, Birgit ^a   Parry, Richard V ^b   Ma, Zhengyu ^a   Fan, Emily ^a   Shivers, Debra K ^a   Freiberg, Benjamin A ^c   Thomas, Anna K ^b   Rutherford, Robert ^b   Rumbley, Catherine A ^b   Riley, James L ^b   Finkel, Terri H ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Intelligent Imaging Innovations   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN VAV1; SYNAPTOTAGMIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VAV PROTEIN;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CALCIUM CELL LEVEL; CELL AGGREGATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; INFECTION; INFECTION SENSITIVITY; LIGAND BINDING; LIPID RAFT; MAGNETISM; POLARIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

EID: 29144456697     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.12.7848     Document Type: Article

References (37)

1. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248: 1349-1356.
2. Appleman, L. J., A. A. van Puijenbroek, K. M. Shu, L. M. Nadler, and V. A. Boussiotis. 2002. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J. Immunol. 168: 2729-2736.
3. Ledbetter, J. A., J. B. Imboden, G. L. Schieven, L. S. Grosmaire, P. S. Rabinovitch, T. Lindsten, C. B. Thompson, and C. H. June. 1990. CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood 75: 1531-1539.
4. Hehner, S. P., T. G. Hofmann, O. Dienz, W. Droge, and M. L. Schmitz. 2000. Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription. J. Biol. Chem. 275: 18160-18171.
5. Zaru, R., C. P. Berne, C. Iurisci, D. Corda, and S. Valitutti. 2001. CD28 costimulates TCR/CD3-induced phosphoinositide turnover in human T lymphocytes. Eur. J. Immunol. 31: 2438-2447.
6. Horejsi, V. 2003. The roles of membrane microdomains (rafts) in T-cell activation. Immunol Rev. 191: 148-164.
7. Bi, K., Y. Tanaka, N. Coudronniere, K. Sugie, S. Hong, M. J. van Stipdonk, and A. Altman. 2001. Antigen-induced translocation of PKC-θ to membrane rafts is required for T-cell activation. Nat. Immunol. 2: 556-563.
8. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283: 680-682.
9. Riley, J. L., M. Mao, S. Kobayashi, M. Biery, J. Burchard, G. Cavet, B. P. Gregson, C. H. June, and P. S. Linsley. 2002. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc. Natl. Acad. Sci. USA 99: 11790-11795.
10. + T-cell proliferation in HIV-positive patients as a result of CD28 costimulation. Science 272: 1939-1943.
11. Thomas, A. K., M. V. Maus, W. S. Shalaby, C. H. June, and J. L. Riley. 2002. A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes. Clin. Immunol. 105: 259-272.
12. Barda-Saad, M., A. Braiman, R. Titerence, S. C. Bunnell, V. A. Barr, and L. E. Samelson. 2005. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat. Immunol. 6: 80-89.
13. + T-cells do not require the polarization of lipid rafts for activation and proliferation. Proc. Natl. Acad. Sci. USA 99: 15006-15011.
14. L, and IL-2 expression in primary human CD4 T lymphocytes. J. Immunol. 171: 166-174.
15. Tavano, R., G. Gri, B. Molon, B. Marinari, C. E. Rudd, L. Tuosto, and A. Viola. 2004. CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes. J. Immunol. 173: 5392-5397.
16. Mandelbrot, D. A., M. A. Oosterwegel, K. Shimizu, A. Yamada, G. J. Freeman, R. N. Mitchell, M. H. Sayegh, and A. H. Sharpe. 2001. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J. Clin. Invest. 107: 881-887.
17. Siefken, R., S. Klein-Hessling, E. Serfling, R. Kurrle, and R. Schwinzer. 1998. A CD28-associated signaling pathway leading to cytokine gene transcription and T-cell proliferation without TCR engagement. J. Immunol. 161: 1645-1651.
18. Kaga, S., S. Ragg, K. A. Rogers, and A. Ochi. 1998. Cutting edge: stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells. J. Immunol. 160: 24-27.
19. Marinari, B., A. Costanzo; A. Viola, F. Michel, G. Mangino, O. Acuto, M. Levrero, E. Piccolella, and L. Tuosto. 2002. Vav cooperates with CD28 to induce NF-κB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. Eur. J. Immunol. 32: 447-456.
20. Piccolella, E., F. Spadaro, C. Ramoni, B. Marinari, A. Costanzo, M. Levrero, L. Thomson, R. T. Abraham, and L. Tuosto. 2003. Vav-1 and the IKKα subunit of IκB kinase functionally associate to induce NF-κB activation in response to CD28 engagement. J. Immunol. 170: 2895-2903.
21. Villalba, M., K. Bi, F. Rodriguez, Y. Tanaka, S. Schoenberger, and A. Altman. 2001. Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T-cells. J. Cell Biol. 155: 331-338.
22. Michel, F., G. Mangino, G. Attal-Bonnefoy, L. Tuosto, A. Alcover, A. Roumier, D. Olive, and O. Acuto. 2000. CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation 2000. J. Immunol. 165: 3820-3829.
23. Kane, L. P., J. Lin, and A. Weiss. 2002. It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends Immunol. 23: 413-420.
24. Diehn, M., A. A. Alizadeh, O. J. Rando, C. L. Liu, K. Stankunas, D. Botstein, G. R. Crabtree, and P. O. Brown. 2002. Genomic expression programs and the integration of the CD28 costimulatory signal in T-cell activation. Proc. Natl. Acad. Sci. USA 99: 11796-11801.
25. Meyer zum Buschenfelde, C., J. Untemaehrer, I. Mellman, and K. Bottomly. 2004. Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J. Immunol. 173: 6119-6124.
26. + thymocytes do not polarize lipid rafts in response to TCR-mediated signals. J. Immunol. 165: 5435-5442.
27. Hare, K. J., J. Pongracz, E. J. Jenkinson, and G. Anderon. 2003. Modeling TCR signaling complex formation in positive selection. J. Immunol. 171: 2825-2831.
28. Burack, W. R., K. H. Lee, A. D. Holdorf, M. L. Dustin, and A. S. Shaw. 2002. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J. Immunol. 169: 2837-2841.
29. Tuosto, L., I. Parolini, S. Schroder, M. Sargiacomo, A. Lanzavecchia, and A. Viola. 2001. Organization of plasma membrane functional rafts upon T-cell activation. Eur. J. Immunol. 31: 345-349.
30. Raab, M., S. Pfister, and C. E. Rudd. 2001. CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity 15: 921-933.
31. Salomon, B., and J. A. Bluestone. 2001. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19: 225-252.
32. Folzenlogen, D., M. F. Hofer, D. Y. Leung, J. H. Freed, and M. K. Newell. 1997. Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients. Clin. Immunol. Immunopathol. 83: 199-204.
33. Nakajima, A., M. Azuma, S. Kodera, S. Nuriya, A. Terashi, M. Abe, S. Hirose, T. Shirai, H. Yagita, and K. Okumura. 1995. Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur. J. Immunol. 25: 3060-3069.
34. Roth, R., T. Nakamura, and M. J. Mamula. 1996. B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T-cells. J. Immunol. 157: 2924-2931.
35. Esser, M. T., D. R. Graham, L. V. Coren, C. M. Trubey, J. W. Bess, Jr., L. O. Arthur, D. E. Ott, and J. D. Lifson. 2001. Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation. J. Virol. 75: 6173-6182.
36. Bounou, S., N. Dumais, and M. J. Tremblay. 2001. Attachment of human immunodeficiency virus-1 (HIV-1) particles bearing host-encoded B7-2 proteins leads to nuclear factor-κB- and nuclear factor of activated T-cells-dependent activation of HIV-1 long terminal repeat transcription. J. Biol. Chem. 276: 6359-6369.
37. + T cells. Science 28: 1353-1357.