Up-regulation of human α7 nicotinic receptors by chronic treatment with activator and antagonist ligands

European Journal of Pharmacology

Volumn 347, Issue 1, 1998, Pages 131-139

  Molinari, Eduardo J ^a   Delbono, Osvaldo ^b   Messi, Maria L ^b   Renganathan, Muthukrishnan ^b   Arneric, Stephen P ^a   Sullivan, James P ^a   Gopalakrishnan, Murali ^a  

^a Neurol and Urological Dis Research   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

bungarotoxin; Methyllycaconitine; Nicotine; Nicotinic receptor, human; Regulation

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ALPHA BUNGAROTOXIN; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR;

ARTICLE; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN TISSUE; KIDNEY; LONG TERM EXPOSURE; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR UPREGULATION; TISSUE DISTRIBUTION;

ACONITINE; BENZYLIDENE COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BUNGAROTOXINS; DIMETHYLPHENYLPIPERAZINIUM IODIDE; HUMANS; INSECTICIDES; IODINE RADIOISOTOPES; KIDNEY; KINETICS; LIGANDS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PYRIDINES; RECEPTORS, NICOTINIC; TRANSFECTION; UP-REGULATION;

EID: 0032540193     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00084-3     Document Type: Article

References (36)

1. Barrantes G.E., Rogers A.T., Lindstrom J., Wonnacott S. α-Bungarotoxin binding sites in rat hippocampal and cortical cultures: Initial characterization, colocalization with α7 subunits and up-regulation by chronic nicotine treatment. Brain Res. 672:1995;228-236.
2. Bencherif M., Fowler K., Lukas R.J., Lippiello P.M. Mechanisms of upregulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain. J. Pharmacol. Exp. Ther. 275:1995;987-994.
3. Benowitz N.L. Pharmacology of nicotine: addiction and therapeutics. Annu. Rev. Pharmacol. Toxicol. 36:1996;597-613.
4. Bertrand D., Bertrand S., Ballivet M. Pharmacological properties of the homomeric α7 receptor. Neurosci. Lett. 146:1992;87-90.
5. Broide R.S., Robertson R.T., Leslie F.M. Regulation of α7 nicotinic acetylcholine receptors in the developing rat somatosensory cortex by thalamocortical afferents. J. Neurosci. 16:1996;2956-2971.
6. Briggs C.A., McKenna D.G., Piattoni-Kaplan M. Human α7 nicotinic acetylcholine receptor responses to novel ligands. Neuropharmacology. 34:1995;583-590.
7. Boulter J., Connelly J., Deneris E., Goldman D., Heinemann S., Patrick J. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. USA. 84:1987;7763-7767.
8. Collins A.C., Luo Y., Selvaag S., Marks M.J. Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion. J. Pharmacol. Exp. Ther. 271:1994;125-133.
9. Couturier S., Bertrand D., Matter J.M., Hernandez M.C., Bertrand S., Millar N., Valera S., Barkas T., Ballivet M. A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX. Neuron. 5:1990;847-856.
10. 2+/calmodulin-dependent kinase pathway. J. Neurosci. 15:1995;7966-7978.
11. Delbono O., Gopalakrishnan M., Renganathan M., Monteggia L.M., Messi M.L., Sullivan J.P. Activation of the recombinant human α7 nicotinic acetylcholine receptor significantly rises intracellular free calcium. J. Pharmacol. Exp. Ther. 280:1997;428-438.
12. Donnelly-Roberts D.L., Xue I.C., Arneric S.P., Sullivan J.P. In vitro neuroprotective properties of the novel cholinergic channel activator, ABT-418. Brain Res. 719:1996;36-44.
13. Doucette-Stamm L., Monteggia L.M., Donnelly-Roberts D., Wang M.T., Lee J., Tian J., Giordano T. Cloning and sequence of the human α7 nicotinic acetylcholine receptor. Drug Dev. Res. 30:1993;252-256.
14. Elgoyhen A.B., Johnson D.S., Boulter J., Vetter D.E., Heinemann S. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell. 79:1994;705-715.
15. Franklin J.L., Johnson E.M. Jr. Suppression of programmed neuronal death by sustained elevation of cytoplasmatic calcium. Trends Neurol. Sci. 15:1992;501-508.
16. Freedman R., Wetmore C., Strömberg I., Leonard S., Olson L. α-Bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J. Neurosci. 13:1993;1965-1975.
17. + and cAMP. Mol. Pharmacol. 34:1988;549-556.
18. 7 nicotinic acetylcholine receptor. Eur. J. Pharmacol. (Mol. Pharm.). 290:1995;237-246.
19. Gopalakrishnan M., Delbono O., Molinari E.J., Renganathan M., Messi L., Arneric S.P., Sullivan J.P. Regulation of recombinant human α7 nicotinic receptors by activator and antagonist ligands. Soc. Neurosci. 22:1996;1527.
20. Gopalakrishnan M., Molinari E.J., Sullivan J.P. Regulation of human α4β2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Mol. Pharmacol. 52:1997;524-534.
21. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflüg. Arch. 391:1981;85-100.
22. Jensen J.J., Winzer-Serhan U.H., Leslie F.M. Glial regulation of α7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons. J. Neurochem. 68:1997;112-120.
23. Lindstrom J. Nicotinic acetylcholine receptors in health and disease. Mol. Neurobiol. 15:1997;193-222.
24. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
25. McGehee D.S., Role L.W. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu. Rev. Physiol. 57:1995;521-546.
26. Messi M.L., Renganathan M., Grigorenko E., Delbono O. Activation of α7 nicotinic acetylcholine receptors promotes survival of spinal cord motoneurons. FEBS Lett. 411:1997;32-38.
27. Moss S.J., McDonald B.J., Rudhard Y., Schoepfer R. Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 subunit by cAMP-dependent protein kinase. Neuropharmacology. 35:1996;1023-1028.
28. Munson P.J., Rodbard D. LIGAND: A versatile computerized approach for the characterization of ligand binding systems. Anal. Biochem. 107:1980;220-239.
29. Pauly J.R., Marks M.J., Gross S.D., Collins A.C. An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment. J. Pharmacol. Exp. Ther. 258:1991;1127-1136.
30. Peng X., Gerzanich V., Anand R., Whiting P.J., Lindstrom J. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46:1994;523-530.
31. Peng X., Gerzanich V., Anand R., Wang F., Lindstrom J. Chronic nicotine treatement up-regulates α3 and α7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y. Mol. Pharmacol. 51:1997;776-784.
32. Quik M., Philie J., Choremis J. Modulation of α7 nicotinic receptor-mediated calcium influx by nicotinic agonists. Mol. Pharmacol. 51:1997;499-506.
33. Ramirez-Latorre J., Yu C.R., Qu X., Perin F., Karlin A., Role L. Functional contributions of α5 subunit to neuronal acetylcholine receptor channels. Nature. 380:1996;347-351.
34. Rathouz M.M., Vijayaraghavan S., Berg D.K. Elevation of intracellular calcium levels in neurons by nicotinic acetylcholine receptors. Mol. Neurobiol. 12:1996;117-131.
35. Sullivan J.P., Anderson D.J., Briggs C.A., Campbell J.E., Donnelly-Roberts D., Gopalakrishnan M., Gunn D., He Y., Holladay M.W., McKenna D., Lin N.H., Molinari E.J., Piattoni-Kaplan M., Xue I., Williams M., Arneric S.P. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinyl methoxy)pyridine dihydrochloride]: A potent and selective cholinergic channel modulator with neuroprotective properties. J. Pharmacol. Exp. Ther. 283:1997;235-246.
36. Wonnacott S. The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol. Sci. 11:1990;216-219.