Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-κB signaling pathway

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 12, 2005, Pages 1591-1597

  Song, Yong Jin ^a   Lee, Dae Young ^a   Kim, Su Nam ^b   Lee, Kang Ro ^b   Lee, Hyang Woo ^b   Han, Jeung Whan ^b   Kang, Dong Won ^a   Lee, Hoi Young ^c   Kim, Yong Kee ^a  

^a Catholic Kwandong University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Konyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CYTOCHROME C; DNA FRAGMENT; ERGOLIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; SESQUITERPENE LACTONE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; INULA; INULA BRITANNICA; LEUKEMIA CELL LINE; NONHUMAN; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

APOPTOSIS; GENES, REPORTER; HELA CELLS; HUMANS; JURKAT CELLS; LACTONES; LUCIFERASES; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 28644448326     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.57.12.0009     Document Type: Article

References (26)

1. Baldwin, A. S. (1996) The NF-κ B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649-683
2. Barkett, M., Gilmore, T. D. (1999) Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18: 6910-6924
3. Cecconi, F. (1999) Apaf1 and the apoptotic machinery. Cell Death Differ. 6: 1087-1098
4. Ghosh, S., May, M. J., Kopp, E. B. (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260
5. Grutter, M. G. (2000) Caspases: key players in programmed cell death. Curr. Opin. Struct. Biol. 10: 649-655
6. Guo, Y. L., Baysal, K., Kang, B., Yang, L. J., Williamson, J. R. (1998) Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells. J. Biol. Chem. 273: 4027-4034
7. Han, J. W., Lee, B. G., Kim, Y. K., Yoon, J. W., Jin, H. K., Hong, S., Lee, H. Y., Lee, K. R., Lee, H. W. (2001) Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB. Br. J. Pharmacol. 133: 503-512
8. Hengartner, M. O. (2000) The biochemistry of apoptosis. Nature 407: 770-776
9. Karin, M., Lin, A. (2002) NF-kappaB at the crossroads of life and death. Nat. Immunol. 3: 221-227
10. Kaufmann, S. H., Earnshaw, W. C. (2000) Induction of apoptosis by cancer chemotherapy. Exp. Cell. Res. 256: 42-49
11. Kaufmann, S. H., Hengartner, M. O. (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11: 526-534
12. Lee, H. T., Yang, S. W., Kim, K. H., Seo, E. K., Mar, W. (2002) Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch. Pharm. Res. 25: 151-153
13. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., Wang, X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489
14. Mayo, M. W., Baldwin, A. S. (2000) The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance. Biochim. Biophys. Acta 1470: M55-M62
15. Mayo, M. W., Denlinger, C. E., Broad, R. M., Yeung, F., Reilly, E. T., Shi, Y., Jones, D. R. (2003) Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. J. Biol. Chem. 278: 18980-18989
16. Murphy, K. M., Streips, U. N., Lock, R. B. (2000) Bcl-2 Inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation. J. Biol. Chem. 275: 17225-17228
17. Nakshatri, H., Rice, S. E., Bhat-Nakshatri, P. (2004) Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Oncogene 23: 7330-7344
18. Pahl, H. L. (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853-6866
19. Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., Lin, A. (2001) Inhibition of JNK activation through NF-kappaB target genes. Nature 414: 313-317
20. Tian, R. H., Zhang, G. Y., Yan, G. H., Dai, Y. R. (1999) Involvement of poly(ADP-ribose) polymerase and activation of caspase-3-like protease in heat shock-induced apoptosis in tobacco suspension cells. FEBS Lett. 474: 11-15
21. Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K. I., Takeda, K., Minowa, O., Miyazono, K., Noda, T., Ichijo, H. K. (2001) ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2: 222-228
22. Wen, J., You, K. R., Lee, S. Y., Song, C. H., Kim, D. G. (2002) Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J. Biol. Chem. 277: 38954-38964
23. Won, Y. K., Ong, C. N., Shi, X. L., Shen, H. M. (2004) Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis 25: 1449-1458
24. Wood, D. E., Newcomb, E. W. (2000) Cleavage of Bax enhances its cell death function. Exp. Cell. Res. 256: 375-382
25. Zhang, S., Lin, Z. N., Yang, C. F., Shi, X., Ong, C. N., Shen, H. M. (2004a) Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis 25: 2191-2199
26. Zhang, S., Ong, C. N., Shen, H. M. (2004b) Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett. 208: 143-153