Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled

Developmental Dynamics

Volumn 234, Issue 4, 2005, Pages 900-910

  Onuma, Yasuko ^a,b   Takahashi, Shuji ^a   Haramoto, Yoshikazu ^a   Tanegashima, Kousuke ^a   Yokota, Chika ^a   Whitman, Malcolm ^b   Asashima, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

BMP; Nodal; TGF superfamily; Wnt; Xenopus; Xnr5

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; MUTANT PROTEIN; NODAL RELATED PROTEIN; PROTEIN NODAL; PROTEIN XNR2; PROTEIN XNR5; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; CHIMERA; CMXNR2 GENE; CMXNR5 GENE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDODERM; EXTRACELLULAR SPACE; GENE; GENE CONSTRUCT; IMMUNOHISTOCHEMISTRY; MESODERM; MICROINJECTION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TARGET CELL; WESTERN BLOTTING; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; EMBRYO, NONMAMMALIAN; IMMUNOHISTOCHEMISTRY; PHOSPHOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS; XENOPUS PROTEINS;

ANIMALIA; VERTEBRATA;

EID: 28444473787     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20574     Document Type: Article

References (47)

1. Agius E, Oelgeschlager M, Wessely O, Kemp C, De Robertis EM. 2000. Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development 127:1173-1183.
2. Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB. 2002. Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol 4:981-985.
3. Bernardini G, Prati M, Bonetti E, Scari G. 1999. Atlas of Xenopus development. Milan: Springer.
4. Birsoy B, Berg L, Williams PH, Smith JC, Wylie CC, Christian JL, Heasman J. 2005. XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development. Development 132:591-602.
5. Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM. 1996. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382:595-601.
6. Brannon M, Kimelman D. 1996. Activation of Siamois by the Wnt pathway. Dev Biol 180:344-347.
7. Christian JL, McMahon JA, McMahon AP, Moon RT. 1991. Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm- inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development 111: 1045-1055.
8. Eimon PM, Harland RM. 2002. Effects of heterodimerization and proteolytic processing on Derriere and Nodal activity: implications for mesoderm induction in Xenopus, Development 129:3089-3103.
9. Evans JP, Kay BK. 1991. Biochemical fractionation of oocytes. Methods Cell Biol 36:133-48.
10. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. 1998. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357-362.
11. Hansen CS, Marion CD, Steele K, George S, Smith WC. 1997. Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3. Development 124:483-492.
12. Haramoto Y, Tanegashima K, Onuma Y, Takahashi S, Sekizaki H, Asashima M. 2004. Xenopus tropicalis nodal-related gene 3 regulates BMP signaling: an essential role for the pro-region. Dev Biol 265:155-168.
13. Harland RM. 1991. In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol 36: 685-695.
14. Hashimoto-Partyka MK, Yuge M, Cho KW. 2003. Nodal signaling in Xenopus gastrulae is cell-autonomous and patterned by beta-catenin. Dev Biol 253:125-138.
15. Hawley SH, Wunnenberg-Stapleton K, Hashimoto C, Laurent MN, Watabe T, Blumberg BW, Cho KW. 1995. Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev 9:2923-2935.
16. He X, Semenov M, Tamai K, Zeng X. 2004. LDL receptor-related proteins 5 and 6 in Wnt/b-catenin signaling: Arrows point the way. Development 131:1663-1677.
17. Hill CS. 2001. TGF-beta signalling pathways in early Xenopus development. Curr Opin Genet Dev 11:533-540.
18. Kazanskaya O, Glinka A, Niehrs C. 2000. The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. Development 127:4981-4992.
19. Kulkarni AB, Thyagarajan T, Letterio JJ. 2002. Function of cytokines within the TGF-b superfamily as determined from transgenic and gene knockout studies in mice. Curr Mol Med 2:303-327.
20. Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. 1997. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol 136:1123-1136.
21. Nieuwkoop PD, Faber J. 1956. Normal table of Xenopus laevis (Daudin). Amsterdam: North-Holland.
22. Nishimatsu S, Thomsen GH. 1998. Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos. Mech Dev 74:75-88.
23. Nishimatsu S, Suzuki A, Shoda A, Murakami K, Ueno N. 1992. Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos. Biochem Biophys Res Commun 186:1487-1495.
24. Onuma Y, Nishinakamura R, Takahashi S, Yokota T, Asashima M. 1999. Molecular cloning of a novel Xenopus spalt gene (Xsal-3). Biochem Biophys Res Commun 264:151-156.
25. Onuma Y, Takahashi S, Yokota C, Asashima M. 2002. Multiple nodal-related genes act coordinately in Xenopus embryogenesis. Dev Biol 241:94-105.
26. Osada SI, Wright CV. 1999. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development 126:3229-3240.
27. Rothbacher U, Laurent MN, Deardorff MA, Klein PS, Cho KW, Fraser SE. 2000. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J 19:1010-1022.
28. Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM. 1994. Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79:779-790.
29. Schier AF. 2003. Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol 19:589-621.
30. Schneider S, Steinbeisser H, Warga RM, Hausen P. 1996. Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev 57:191-198.
31. Shi Y, Massague J. 2003. Mechanisms of TGF-β Signaling from cell membrane to the nucleus. Cell 113:685-700.
32. Sive HL, Hattori K, Weintraub H. 1989. Progressive determination during formation of the anteroposterior axis in Xenopus laevis. Cell 58:171-180.
33. Sive HL, Grainger RM, Harland RM. 2000. Early development of Xenopus laevis: a laboratory manual. Cold Spring, NY: Cold Spring Harbor Laboratory Press.
34. Smith WC, Harland RM. 1991. Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell 67:753-765.
35. Smith WC, McKendry R, Ribisi S, Harland RM. 1995. A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell 82:37-46.
36. Sokol S, Christian JL, Moon RT, Melton DA. 1991. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67:741-752.
37. Sun BI, Bush SM, Collins-Racie LA, LaVallie ER, DiBlasio-Smith EA, Wolfman NM, McCoy JM, Sive HL. 1999. derriere: a TGF-beta family member required for posterior development in Xenopus. Development 126:1467-1482.
38. Sussman DJ, Klingensmith J, Salinas P, Adams PS, Nusse R, Perrimon N. 1994. Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol 166:73-86.
39. Suzuki A, Ueno N, Hemmati-Brivanlou A. 1997. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. Development 124:3037-3044.
40. Takahashi S, Uochi T, Kawakami Y, Nohno T, Yokota C, Kinoshita K, Asashima M. 1998. Cloning and expression pattern of Xenopus prx-1 (Xprx-1) during embryonic development. Dev Growth Differ 40:97-104.
41. Takahashi S, Yokota C, Takano K, Tanegashima K, Onuma Y, Goto J, Asashima M. 2000. Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center. Development 127: 5319-5329.
42. Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J. 2005. Maternal wnt 11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871.
43. Whitman M. 2001. Nodal signaling in early vertebrate embryos: themes and variations. Dev Cell 1:605-617.
44. Wodarz A, Nusse R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
45. Xanthos JB, Kofron M, Wylie C, Heasman J. 2001. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development 128:167-180.
46. Yeo C, Whitman M. 2001. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell 7:949-957.
47. Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D. 1998. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 93:1031-1041.