Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice

Neuroscience Letters

Volumn 392, Issue 3, 2006, Pages 202-206

  Aguiar, Jorge ^a   Fernández, Julio ^a   Aguilar, Anselmo ^a   Mendoza, Yssel ^a   Vázquez, María ^a   Suárez, José ^a   Berlanga, Jorge ^a   Cruz, Silian ^a   Guillén, Gerardo ^a   Herrera, Luis ^a   Velázquez, Luis ^b   Santos, Nieves ^b   Merino, Nelson ^c  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b Centro para la Investigacion y Rehabilitacion de las Ataxias Hereditarias Cuba   (Cuba)

^c Food and Pharmaceutics Institute (IFAL)   (Cuba)

Author keywords

SCA2 disease; Transgenic mice; Ubiquitous expression

Indexed keywords

ATAXIN 2; BETA ACTIN; CALBINDIN; COMPLEMENTARY DNA; NUCLEIC ACID BINDING PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DEGENERATIVE DISEASE; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HYBRID; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; LUNG; MOTOR COORDINATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PURKINJE CELL; RNA HYBRIDIZATION; SKELETAL MUSCLE; TISSUE DISTRIBUTION; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); PURKINJE CELLS; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROTAROD PERFORMANCE TEST; SPINOCEREBELLAR DEGENERATIONS; TIME FACTORS;

EID: 28444463350     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.09.020     Document Type: Article

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