Current and future prospects for the prevention of ocular fibrosis

Ophthalmology Clinics of North America

Volumn 18, Issue 4, 2005, Pages 539-559

  Dahlmann, Annegret H ^a   Mireskandari, Kamiar ^a   Cambrey, Alison D ^a   Bailly, Maryse ^a   Tee Khaw, Peng ^a  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIFIBROTIC AGENT; BLEOMYCIN; CHYMASE INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYCLOSPORIN; CYCLOSPORIN A; DAUNORUBICIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISINTEGRIN; FIBRINOLYTIC AGENT; FLUOROURACIL; GENISTEIN; GLUCOSAMINE DERIVATIVE; GROWTH FACTOR; MITOMYCIN C; NONSTEROID ANTIINFLAMMATORY AGENT; RIBOZYME; SIMVASTATIN; SMALL INTERFERING RNA; SNAKE VENOM; STEROID; SURAMIN; THIOTEPA; TISSUE PLASMINOGEN ACTIVATOR; TRANILAST; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNINDEXED DRUG; UROKINASE;

AMNION; CATARACT EXTRACTION; CELL MOTION; CELL PROLIFERATION; CONJUNCTIVA; CONJUNCTIVITIS; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; ELECTRON THERAPY; EXTRACELLULAR MATRIX; EYE SURGERY; GENE THERAPY; HEALING; HUMAN; INTRAOCULAR HEMORRHAGE; LACRIMAL DUCT; LENS EPITHELIUM; LENS IMPLANT; NERVE COMPRESSION; NERVE DECOMPRESSION; NONHUMAN; OCULAR FIBROSIS; OPTIC NERVE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROPHYLAXIS; RETINA MACULA DEGENERATION; REVIEW; SCAR FORMATION; SURGICAL TECHNIQUE; UVEITIS;

ANIMALS; EYE; EYE DISEASES; FIBROSIS; HUMANS; OPHTHALMOLOGIC SURGICAL PROCEDURES; POSTOPERATIVE COMPLICATIONS; WOUND HEALING;

EID: 28444451202     PISSN: 08961549     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ohc.2005.07.006     Document Type: Review

References (143)

1. P. Martin Wound healing-aiming for perfect skin regeneration Science 276 1997 75 81
2. D.C. Broadway, I. Grierson, and J. Sturmer Reversal of topical antiglaucoma medication effects on the conjunctiva Arch Ophthalmol 114 1996 262 267
3. K.D. Nguyen, and D.A. Lee Effect of steroids and nonsteroidal antiinflammatory agents on human ocular fibroblast Invest Ophthalmol Vis Sci 33 1992 2693 2701
4. E. Turacli, K. Gunduz, and G. Aktan A comparative clinical trial of mitomycin C and cyclosporin A in trabeculectomy Eur J Ophthalmol 6 1996 398 401
5. E. Chihara, J. Dong, and H. Ochiai Effects of tranilast on filtering blebs: a pilot study J Glaucoma 11 2002 127 133
6. E.K. Kim, T.G. Peterson, and S. Barnes Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor β signaling pathways Am J Clin Nutr 68 Suppl 1998 S1418 S1425
7. H. Sakaguchi, S. Takai, and M. Sakaguchi Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery Curr Eye Res 24 2002 325 331
8. H. Nakamura, S.S. Siddiqui, and X. Shen RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis Mol Vis 10 2004 703 711
9. K.L. Watts, E.M. Sampson, and G.S. Schultz Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts Am J Respir Cell Mol Biol 32 2005 290 300
10. J.F. Kirwan, P.H. Constable, and I.E. Murdoch Beta irradiation: new uses for an old treatment: a review Eye 17 2003 207 215
11. T.J. Zimmermann, K.S. Kooner, and M. Sharir Textbook of ocular pharmacology 1997 Lippincott Raven Philadelphia
12. J.H. Rabowsky, A.J. Dukes, and D.A. Lee The use of bioerodible polymers and daunorubicin in glaucoma filtration surgery Ophthalmology 103 1996 800 807
13. Y. Oshima, T. Sakamoto, and T. Nakamura The comparative benefits of glaucoma filtering surgery with an electric-pulse targeted drug delivery system demonstrated in an animal model Ophthalmology 106 1999 1140 1146
14. M. Batterbury, C. Tebbs, and J. Rhodes Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contraction Exp Eye Res 74 2002 361 370
15. J.P. Joseph, I. Grierson, and R.A. Hitchings Taxol, cytochalasin B and colchicine effects on fibroblast migration and contraction: a role in glaucoma filtration surgery? Curr Eye Res 8 1989 203 215
16. H.D. Jampel, D. Thibault, and K.W. Leong Glaucoma filtration surgery in nonhuman primates using Taxol and etoposide in polyanhydride carriers Invest Ophthalmol Vis Sci 34 1993 3076 3083
17. S. Saika, A. Ooshima, and O. Yamanaka Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro Graefes Arch Clin Exp Ophthalmol 234 Suppl 1 1996 S214 S222
18. A.P. Wells, M.F. Cordeiro, and C. Bunce Cystic bleb formation and related complications in limbus- versus fornix-based conjunctival flaps in pediatric and young adult trabeculectomy with mitomycin C Ophthalmology 110 2003 2192 2197
19. P. Khaw, A. Dahlmann, and K. Mireskandari The Moorfields Safe Surgery System with new adjustable sutures Glaucoma Today 3 2005 22 29
20. S.V. Araujo, G.L. Spaeth, and S.M. Roth A ten-year follow-up on a prospective, randomized trial of postoperative corticosteroids after trabeculectomy Ophthalmology 102 1995 1753 1759
21. A. Azuara-Blanco, G.L. Spaeth, and J.J. Augsburger Oral prednisone in guarded filtration procedures supplemented with antimetabolites Ophthalmic Surg Lasers 30 1999 126 132
22. A.R. Kent, H.B. Dubiner, and R. Whitaker The efficacy and safety of diclofenac 0.1% versus prednisolone acetate 1% following trabeculectomy with adjunctive mitomycin-C Ophthalmic Surg Lasers 29 1998 562 569
23. S. Shaunak, S. Thomas, and E. Gianasi Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation Nat Biotechnol 22 2004 977 984
24. D. WuDunn Intracameral urokinase for dissolution of fibrin or blood clots after glaucoma surgery Am J Ophthalmol 124 1997 693 695
25. A.J. Gray, J.E. Bishop, and J.T. Reeves A alpha and B beta chains of fibrinogen stimulate proliferation of human fibroblasts J Cell Sci 104 1993 409 413
26. L. Chang, J. Crowston, and M. Cordeiro The role of the immune system in conjunctival wound healing after glaucoma surgery Surv Ophthalmol 45 2000 49 68
27. P.T. Khaw, N.L. Occleston, and G. Schultz Activation and suppression of fibroblast function Eye 8 1994 188 195
28. H. Mietz, P. Chevez-Barrios, and R.M. Feldman Suramin inhibits wound healing following filtering procedures for glaucoma Br J Ophthalmol 82 1998 816 820
29. H. Mietz, and G.K. Krieglstein Suramin to enhance glaucoma filtering procedures: a clinical comparison with mitomycin Ophthalmic Surg Lasers 32 2001 358 369
30. M.C. Gillies, A.M. Brooks, and S. Young A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy Aust NZ J Ophthalmol 27 1999 37 44
31. M.F. Cordeiro, A. Mead, and R.R. Ali Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome Gene Ther 10 2003 59 71
32. M.F. Cordeiro, J.A. Gay, and P.T. Khaw Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent Invest Ophthalmol Vis Sci 40 1999 2225 2234
33. D. Siriwardena, P.T. Khaw, and A.J. King Human antitransforming growth factor beta(2) monoclonal antibody-a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study Ophthalmology 109 2002 427 431
34. A. Mead, T. Wong, and M. Cordeiro Anti-transforming growth factor-b2 antibody: a new post operative anti-scarring agent in glaucoma surgery Invest Ophthalmol Vis Sci 44 2003 3394 3401
35. S.J. Chen, W. Yuan, and Y. Mori Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3 J Invest Dermatol 112 1999 49 57
36. J. Massague Wounding Smad Nat Cell Biol 1 1999 E117 E119
37. A. Leask, and D.J. Abraham TGF-beta signaling and the fibrotic response FASEB J 18 2004 816 827
38. M. Schiller, D. Javelaud, and A. Mauviel TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing J Dermatol Sci 35 2004 83 92
39. P. Khaw, S. Ward, and I. Grierson The effects of beta-radiation on proliferating human Tenon's capsule fibroblasts Br J Ophthalmol 75 1991 580 583
40. Cook C., Roux P., Stulting A., et al. A randomized controlled trial of beta-irradiation augmentation of trabeculectomy in the management of glaucoma in Africans. 5th IGS Symposium, Capetown, South Africa. Abstracts Volume; 2005:A35
41. M.H. Miller, and N.S. Rice Trabeculectomy combined with beta irradiation for congenital glaucoma Br J Ophthalmol 75 1991 584 590
42. The Fluorouracil Filtering Surgery Study Group Fluorouracil Filtering Surgery Study one-year follow-up Am J Ophthalmol 108 1989 625 635
43. C. Chen Enhanced intraocular pressure controlling effectiveness of trabeculectomy by local application of mitomycin C Trans Asia Pacif Acad Ophthalmol 9 1983 172 177
44. J.C. Cheung, M.M. Wright, and S. Murali Intermediate-term outcome of variable dose mitomycin C filtering surgery Ophthalmology 104 1997 143 149
45. Group TFFSS Five-year follow-up of the Fluorouracil Filtering Surgery Study Am J Ophthalmol 121 1996 349 366
46. P. Khaw, M. Sherwood, and S. MacKay 5-minute treatments with fluorouracil, floxuridine and mitomycin have long-term effects on human Tenon's capsule fibroblasts Arch Ophthalmol 110 1992 1150 1154
47. P.T. Khaw, J.W. Doyle, and M.B. Sherwood Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit Ophthalmology 100 1993 367 372
48. P. Khaw, D. Minassian, and V. Farewell Moorfields/MRC UK 5-FU Glaucoma Study. A randomized prospective trial of intraoperative 5-FU vs placebo: effect on long term pressure control and glaucoma progression. Abstracts Vol 2004 AAO New Orleans 83
49. K. Singh, K. Mehta, and N.M. Shaikh Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial Ophthalmology 107 2000 2305 2309
50. W.L. Membrey, D.P. Poinoosawmy, and C. Bunce Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 1. Intraocular pressure control and complications Br J Ophthalmol 84 2000 586 590
51. M.F. Cordeiro, P.H. Constable, and R.A. Alexander Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit Invest Ophthalmol Vis Sci 38 1997 1639 1646
52. S. Grisanti, A. Gralla, and P. Maurer Cellular photoablation to control postoperative fibrosis in filtration surgery: in vitro studies Exp Eye Res 70 2000 145 152
53. M. Diestelhorst, and S. Grisanti Photodynamic therapy to control fibrosis in human glaucomatous eyes after trabeculectomy: a clinical pilot study Arch Ophthalmol 120 2002 130 134
54. J.F. Jordan, M. Diestelhorst, and S. Grisanti Photodynamic modulation of wound healing in glaucoma filtration surgery Br J Ophthalmol 87 2003 870 875
55. T. Perkins, B. Faha, and M. Ni Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery Arch Ophthalmol 120 2002 941 949
56. D. Paikal, G. Zhang, and Q. Cheng The effect of integrin antibodies on the attachment and proliferation of human Tenon's capsule fibroblasts Exp Eye Res 70 2000 393 400
57. M. Akimoto, M. Hangai, and K. Okazak Growth inhibition of cultured human Tenon's fibroblastic cells by targeting the E2F transcription factor Exp Eye Res 67 1998 395 401
58. J. Daniels, A. Cambrey, and N. Occleston Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro Invest Ophthalmol Vis Sci 44 2003 1104 1110
59. T.T. Wong, A.L. Mead, and P.T. Khaw Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery Invest Ophthalmol Vis Sci 44 2003 1097 1103
60. T. Wong, A. Mead, and P. Khaw Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery Invest Ophthalmol Vis Sci 46 2005 2018 2022
61. H.D. Jampel, and J.I. Moon The effect of paclitaxel powder on glaucoma filtration surgery in rabbits J Glaucoma 7 1998 170 177
62. L.J. McGuigan, R.P. Mason, and R. Sanchez D-penicillamine and beta-aminopropionitrile effects on experimental filtering surgery Invest Ophthalmol Vis Sci 28 1987 1625 1629
63. D.J. Apple, J. Ram, and A. Foster Elimination of cataract blindness: a global perspective entering the new millennium Surv Ophthalmol 45 Suppl 1 2000 S1 S196
64. E.J. Hollick, D.J. Spalton, and W.R. Meacock The effect of capsulorrhexis size on posterior capsular opacification: one-year results of a randomized prospective trial Am J Ophthalmol 128 1999 271 279
65. O. Nishi, and K. Nishi Preventing posterior capsule opacification by creating a discontinuous sharp bend in the capsule J Cataract Refract Surg 25 1999 521 526
66. O. Nishi, K. Nishi, and Y. Osakabe Effect of intraocular lenses on preventing posterior capsule opacification: design versus material J Cataract Refract Surg 30 2004 2170 2176
67. A. Maloof, G. Neilson, and E.J. Milverton Selective and specific targeting of lens epithelial cells during cataract surgery using sealed-capsule irrigation J Cataract Refract Surg 29 2003 1566 1568
68. H.J. Koh, S.J. Kang, and S.J. Lim The effect of photodynamic therapy with rose bengal on posterior capsule opacification in rabbit eyes Ophthalmic Res 34 2002 107 112
69. A. Zaczek, C.G. Laurell, and C. Zetterstrom Posterior capsule opacification after phacoemulsification in patients with postoperative steroidal and nonsteroidal treatment J Cataract Refract Surg 30 2004 316 320
70. U.U. Inan, F. Ozturk, and S. Kaynak Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents J Cataract Refract Surg 27 2001 1079 1087
71. D.H. Shin, Y.Y. Kim, and J. Ren Decrease of capsular opacification with adjunctive mitomycin C in combined glaucoma and cataract surgery Ophthalmology 105 1998 1222 1226
72. D.S. Clark, J.M. Emery, and M.F. Munsell Inhibition of posterior capsule opacification with an immunotoxin specific for lens epithelial cells: 24 month clinical results J Cataract Refract Surg 24 1998 1614 1620
73. W.R. Meacock, D.J. Spalton, and E.J. Hollick Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opacification J Cataract Refract Surg 26 2000 716 721
74. T.T. Wong, J.T. Daniels, and J.G. Crowston MMP inhibition prevents human lens epithelial cell migration and contraction of the lens capsule Br J Ophthalmol 88 2004 868 872
75. I.M. Wormstone, S. Tamiya, and I. Anderson TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag Invest Ophthalmol Vis Sci 43 2002 2301 2308
76. F. Malecaze, B. Couderc, and S. de Neuville Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits Hum Gene Ther 10 1999 2365 2372
77. K.M. Meek, D.W. Leonard, and C.J. Connon Transparency, swelling and scarring in the corneal stroma Eye 17 2003 927 936
78. J.V. Jester, T. Moller-Pedersen, and J. Huang The cellular basis of corneal transparency: evidence for 'corneal crystallins' J Cell Sci 112 Pt 5 1999 613 622
79. R.R. Mohan, A.E. Hutcheon, and R. Choi Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK Exp Eye Res 76 2003 71 87
80. J.D. Zieske, S.R. Guimaraes, and A.E. Hutcheon Kinetics of keratocyte proliferation in response to epithelial debridement Exp Eye Res 72 2001 33 39
81. B.M. Stramer, J.D. Zieske, and J.C. Jung Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes Invest Ophthalmol Vis Sci 44 2003 4237 4246
82. H.K. Lee, J.K. Kim, and E.K. Kim Phototherapeutic keratectomy with amniotic membrane for severe subepithelial fibrosis following excimer laser refractive surgery J Cataract Refract Surg 29 2003 1430 1435
83. D.S. Gartry, M.G. Muir, and C.P. Lohmann The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy. A prospective, randomized, double-blind trial Arch Ophthalmol 110 1992 944 952
84. Y. Kaji, S. Amano, and T. Oshika Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy J Cataract Refract Surg 26 2000 426 431
85. P.A. Majmudar, S.L. Forstot, and R.F. Dennis Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery Ophthalmology 107 2000 89 94
86. C. Gambato, A. Ghirlando, and E. Moretto Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes Ophthalmology 112 2005 208 218 [discussion 219]
87. T. Moller-Pedersen, H.D. Cavanagh, and W.M. Petroll Neutralizing antibody to TGFbeta modulates stromal fibrosis but not regression of photoablative effect following PRK Curr Eye Res 17 1998 736 747
88. A.G. Secchi, and M.S. Tognon Intraoperative mitomycin C in the treatment of cicatricial obliterations of conjunctival fornices Am J Ophthalmol 122 1996 728 730
89. E.D. Donnenfeld, H.D. Perry, and A. Wallerstein Subconjunctival mitomycin C for the treatment of ocular cicatricial pemphigoid Ophthalmology 106 1999 72 78 [discussion 79]
90. M.S. Razzaque, C.S. Foster, and A.R. Ahmed Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid Invest Ophthalmol Vis Sci 44 2003 1998 2003
91. R.S. Rubinfeld, R.R. Pfister, and R.M. Stein Serious complications of topical mitomycin-C after pterygium surgery Ophthalmology 99 1992 1647 1654
92. A.L. Young, G.Y. Leung, and A.K. Wong A randomised trial comparing 0.02% mitomycin C and limbal conjunctival autograft after excision of primary pterygium Br J Ophthalmol 88 2004 995 997
93. S. Dadeya, M.S. Kamlesh, and C. Khurana Intraoperative daunorubicin versus conjunctival autograft in primary pterygium surgery Cornea 21 2002 766 769
94. I.M. Jurgenliemk-Schulz, L.J. Hartman, and J.M. Roesink Prevention of pterygium recurrence by postoperative single-dose beta-irradiation: a prospective randomized clinical double-blind trial Int J Radiat Oncol Biol Phys 59 2004 1138 1147
95. D. Hu, B.S. Sires, and D.C. Tong Effect of brief exposure to mitomycin C on cultured human nasal mucosa fibroblasts Ophthal Plast Reconstr Surg 16 2000 119 125
96. Y.A. You, and C.T. Fang Intraoperative mitomycin C in dacryocystorhinostomy Ophthal Plast Reconstr Surg 17 2001 115 119
97. J.G. Camara, A.U. Bengzon, and R.D. Henson The safety and efficacy of mitomycin C in endonasal endoscopic laser-assisted dacryocystorhinostomy Ophthal Plast Reconstr Surg 16 2000 114 118
98. K. Bakri, N.S. Jones, and R. Downes Intraoperative fluorouracil in endonasal laser dacryocystorhinostomy Arch Otolaryngol Head Neck Surg 129 2003 233 235
99. W.M. Wiersinga, and M.F. Prummel Pathogenesis of Graves' ophthalmopathy-current understanding J Clin Endocrinol Metab 86 2001 501 503
100. L. Koumas, T.J. Smith, and S. Feldon Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes Am J Pathol 163 2003 1291 1300
101. R. Behbehani, R.C. Sergott, and P.J. Savino Orbital radiotherapy for thyroid-related orbitopathy Curr Opin Ophthalmol 15 2004 479 482
102. A.W. Kung, J. Michon, and K.S. Tai The effect of somatostatin versus corticosteroid in the treatment of Graves' ophthalmopathy Thyroid 6 1996 381 384
103. D. Pasquali, A. Bellastella, and V. Colantuoni All-trans retinoic acid- and N-(4-hydroxyphenil)-retinamide-induced growth arrest and apoptosis in orbital fibroblasts in Graves' disease Metabolism 52 2003 1387 1392
104. H. Lew, S.Y. Lee, and W.I. Yang A morphological study of drill holes applied with mitomycin-C in hydroxyapatite orbital implants Ophthalmic Res 33 2001 340 344
105. T.C. Spoor, J.G. McHenry, and D.H. Shin Long-term results using adjunctive mitomycin C in optic nerve sheath decompression for pseudotumor cerebri Ophthalmology 102 1995 2024 2028
106. R. Spinks, S. Baker, and A. Jackson The problem of dural scaring: a solution using 5-fluorouracil J Neurophysiol 90 2003 1324 1332
107. J.H. Kim, S.Y. Jeong, and M.H. Jung Use of polyurethane with sustained release dexamethasone in delayed adjustable strabismus surgery Br J Ophthalmol 88 2004 1450 1454
108. J.M. Hwang, and B.L. Chang Combined effect of polytetrafluoroethylene and 5-fluorouracil on delayed adjustable strabismus surgery J Pediatr Ophthalmol Strabismus 37 2000 163 167
109. A. Esme, C. Yildirim, and S. Tatlipinar Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits Strabismus 12 2004 141 148
110. J.C. Pastor, E.R. de la Rua, and F. Martin Proliferative vitreoretinopathy: risk factors and pathobiology Prog Retin Eye Res 21 2002 127 144
111. Silicone Study Report 2 Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial Arch Ophthalmol 110 1992 780 792
112. P. Wiedemann, R.D. Hilgers, and P. Bauer Adjunctive daunorubicin in the treatment of proliferative vitreoretinopathy: results of a multicenter clinical trial. Daunomycin Study Group Am J Ophthalmol 126 1998 550 559
113. C. Kon, N. Occleston, and A. Foss Effects of single, short-term exposures of human retinal pigment epithelial cells to thiotepa or 5-fluorouracil: implications for the treatment of proliferative vitreoretinopathy Br J Ophthalmol 82 1998 554 560
114. R. Asaria, C. Kon, and C. Bunce Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy: results from a randomized, double-blind, controlled clinical trial Ophthalmology 108 2001 1179 1183
115. D.G. Charteris, G.W. Aylward, and D. Wong A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy Ophthalmology 111 2004 2240 2245
116. K. Shinohara, M. Tanaka, and T. Sakuma Efficacy of daunorubicin encapsulated in liposome for the treatment of proliferative vitreoretinopathy Ophthalmic Surg Lasers Imag 34 2003 299 305
117. R. Herrero-Vanrell, and M.F. Refojo Biodegradable microspheres for vitreoretinal drug delivery Adv Drug Deliv Rev 52 2001 5 16
118. T. Yasukawa, H. Kimura, and Y. Tabata Biodegradable scleral plugs for vitreoretinal drug delivery Adv Drug Deliv Rev 52 2001 25 36
119. J.A. Cardillo, M.E. Farah, and J. Mitre An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy Br J Ophthalmol 88 2004 1201 1205
120. P. Jolimaitre, M. Malet-Martino, and R. Martino Fluorouracil prodrugs for the treatment of proliferative vitreoretinopathy: formulation in silicone oil and in vitro release of fluorouracil Int J Pharm 259 2003 181 192
121. C. Garcia, D.U. Bartsch, and M.E. Rivero Efficacy of Prinomastat (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization Curr Eye Res 24 2002 33 38
122. C. Sheridan, N. Occleston, and P. Hiscott Matrix metalloproteinases: a role in the contraction of vitreoretinal scar tissue (GDFB) Am J Path 159 2001 1555 1566
123. P.V. Algvere, C. Libert, and G. Lindgarde Transpupillary thermotherapy of predominantly occult choroidal neovascularization in age-related macular degeneration with 12 months follow-up Acta Ophthalmol Scand 81 2003 110 117
124. D.M. Marcus, E. Peskin, and M. Maguire The age-related macular degeneration radiotherapy trial (AMDRT): one year results from a pilot study Am J Ophthalmol 138 2004 818 828
125. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials-TAP report Arch Ophthalmol 117 1999 1329 1345
126. N.M. Bressler Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-TAP report 2 Arch Ophthalmol 119 2001 198 207
127. N.M. Bressler Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2 Am J Ophthalmol 133 2002 168 169
128. M. Azab, D.S. Boyer, and N.M. Bressler Verteporfin therapy of subfoveal minimally classic choroidal neovascularization in age-related macular degeneration: 2-year results of a randomized clinical trial Arch Ophthalmol 123 2005 448 457
129. R.F. Spaide, J. Sorenson, and L. Maranan Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization Ophthalmology 110 2003 1517 1525
130. M.C. Gillies, J.M. Simpson, and W. Luo A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: one-year results Arch Ophthalmol 121 2003 667 673
131. J.B. Jonas, I. Kreissig, and P. Hugger Intravitreal triamcinolone acetonide for exudative age related macular degeneration Br J Ophthalmol 87 2003 462 468
132. D.J. D'Amico, M.F. Goldberg, and H. Hudson Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in age-related macular degeneration: twelve-month clinical outcomes Ophthalmology 110 2003 2372 2383 [discussion 2384-5]
133. Eyetech Study Group Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration Retina 22 2002 143 152
134. E.S. Gragoudas, A.P. Adamis, and E.T. Cunningham Jr Pegaptanib for neovascular age-related macular degeneration N Engl J Med 351 2004 2805 2816
135. M.G. Krzystolik, M.A. Afshari, and A.P. Adamis Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment Arch Ophthalmol 120 2002 338 346
136. G. McMahon VEGF receptor signaling in tumor angiogenesis Oncologist 5 Suppl 1 2000 3 10
137. D.E. Weng, and N. Usman Angiozyme: a novel angiogenesis inhibitor Curr Oncol Rep 3 2001 141 146
138. R.B. Bhisitkul, G.S. Robinson, and R.S. Moulton An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization Arch Ophthalmol 123 2005 214 219
139. S.J. Reich, J. Fosnot, and A. Kuroki Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model Mol Vis 9 2003 210 216
140. T. Usui, S. Ishida, and K. Yamashiro VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2 Invest Ophthalmol Vis Sci 45 2004 368 374
141. N.N. Markomichelakis, P.G. Theodossiadis, and P.P. Sfikakis Regression of neovascular age-related macular degeneration following infliximab therapy Am J Ophthalmol 139 2005 537 540
142. C. Behrendt Visual acuity and its decrease in classic neovascular age-related macular degeneration Ophthalmic Epidemiol 11 2004 359 367
143. K. Cho, L. Yang, and B. Lu Re-establishing the regenerative potential of central nervous system axons in postnatal mice J Cell Sci 118 2005 863 872