Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opacification

Journal of Cataract and Refractive Surgery

Volumn 26, Issue 5, 2000, Pages 716-721

  Meacock, William R ^a   Spalton, David J ^a   Hollick, Emma J ^a   Boyce, James F ^a   Barman, Sarah ^a   Sanguinetti, Giorgia ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIBODY; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORNEA EPITHELIUM; DIABETIC RETINOPATHY; HUMAN; LENS EPITHELIUM; LENS IMPLANT; PHACOEMULSIFICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CAPSULORHEXIS; CATARACT; CELL COUNT; DOUBLE-BLIND METHOD; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOTOXINS; LENS CAPSULE, CRYSTALLINE; LENS IMPLANTATION, INTRAOCULAR; LENS, CRYSTALLINE; MALE; PHACOEMULSIFICATION; POLYMETHYL METHACRYLATE; PROSPECTIVE STUDIES; RICIN; SAFETY;

EID: 0034127734     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0886-3350(00)00326-6     Document Type: Article

References (16)

1. Apple D.J., Solomon K.D., Tetz M.R., et al. Posterior capsule opacification. Surv Ophthalmol. 37:1992;73-116.
2. Kappelhof J.P., Vrensen G.F.J.M. The pathology of after-cataract; a minireview. Acta Ophthalmol Suppl. 205:1992;13-24.
3. Kelleher P.J., Tarsio J.F., Clark D.S., et al. Cytotoxic effects of a monoclonal antibody-ricin a immunotoxin on human ocular cells in culture. ARVO abstract 2383. Invest Ophthalmol Vis Sci. 33:1992;1168.
4. Crosson C.E., Kelleher P.J., Lam D.M.-K. Ocular pharmacokinetics of lens epithelial cell-specific immunotoxin 4197X-RA. Exp Eye Res. 55:1992;87-91.
5. Fulton R.J., Blakey D.C., Knowles P.P., et al. Purification of ricin A1, A2, and B chains and characterization of their toxicity. J Biol Chem. 261:1986;5314-5319.
6. Ravalico G., Tognetto D., Palomba M.A., et al. Corneal endothelial function after extracapsular cataract extraction and phacoemulsification. J Cataract Refract Surg. 23:1997;1000-1005.
7. Zetterström C., Laurell C.-G. Comparison of endothelial cell loss and phacoemulsification energy during endocapsular phacoemulsification surgery. J Cataract Refract Surg. 21:1995;55-58.
8. Kreisler K.R., Mortenson S.W., Mamalis N. Endothelial cell loss following "modern" phacoemulsification by a senior resident. Ophthalmic Surg. 23:1992;158-160.
9. Faulkner G.D. Endothelial cell loss after phacoemulsification and insertion of silicone lens implants. J Cataract Refract Surg. 13:1987;649-652.
10. Shah S.M., Spalton D.J. Changes in anterior chamber flare and cells following cataract surgery. Br J Ophthalmol. 78:1994;91-94.
11. Shah S.M., Spalton D.J., Smith S.E. Measurement of aqueous cells and flare in normal eyes. Br J Ophthalmol. 75:1991;348-352.
12. Clark D.S., Emery J.M., Munsell M.F. Inhibition of posterior capsule opacification with an immunotoxin specific for lens epithelial cells 24 month clinical results . J Cataract Refract Surg. 24:1998;1614-1620.
13. Shah S.M., Spalton D.J., Kerr Muir M. Specular microscopy of the anterior intraocular lens surface. Eye. 7:1993;707-710.
14. Wolter J.R. Foreign body giant cells on intraocular lens implants. Graefes Arch Clin Exp Ophthalmol. 219:1982;103-111.
15. Wolter J.R. Cytopathology of intraocular lens implantation. Ophthalmology. 92:1985;135-142.
16. Wenzel M. Specular Microscopy of Intraocular Lenses; Atlas and Textbook for Slit-Lamp and Specular Microscopic Examinations. New York, NY, George Thieme Verlag, 1993.