Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK

Experimental Eye Research

Volumn 76, Issue 1, 2003, Pages 71-87

  Mohan, Rahul R ^a   Hutcheon, Audrey E K ^b   Choi, Rosan ^a   Hong, JongWook ^a,c   Lee, JongSoo ^a,d   Mohan, Rajiv R ^a   Ambrósio Jr , Renato ^a,e   Zieske, James D ^b   Wilson, Steven E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c Korea University   (South Korea)

^d Pusan National University School of Medicine   (South Korea)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Electron microscopy; Keratocytes; LASIK; Myofibroblast; Necrosis; PRK; Proliferation; Stroma; Wound healing

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA; CORNEA CELL; ELECTRON MICROSCOPY; FEMALE; FIBROBLAST; IMMUNOCYTOCHEMISTRY; INFLAMMATORY CELL; KERATECTOMY; KERATOMILEUSIS; MONOCYTE; MYOFIBROBLAST; MYOPIA; NICK END LABELING; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RABBIT; STROMA; STROMA CELL; WOUND HEALING;

ANIMALS; APOPTOSIS; CELL DIVISION; CORNEAL STROMA; FEMALE; FIBROBLASTS; IN SITU NICK-END LABELING; KERATECTOMY, PHOTOREFRACTIVE, EXCIMER LASER; KERATOMILEUSIS, LASER IN SITU; MYOPIA; NECROSIS; POSTOPERATIVE PERIOD; RABBITS; WOUND HEALING;

EID: 0037287693     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4835(02)00251-8     Document Type: Article

References (44)

1. Ambrósio R. Jr., Wilson S.E. Complications of laser in situ keratomileusis: etiology, prevention, and treatment. J. Refract. Surg. 17:2000;350-379.
2. Ambrósio, R., Jr., and coworkers, 2002. Early wound healing response to epithelial scrape injury in the human cornea. Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Program No. 4206 (May 2002).
3. Andresen J.L., Ehlers N. Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta. Curr. Eye Res. 17:1998;79-87.
4. Brint S.F., Ostrick D.M., Fisher C., Slade S.G., Maloney R.K., Epstein R., Stulting R.D., Thompson K.P. Six-month results of the multicenter phase I study of excimer laser myopic keratomileusis. J. Cataract Refract. Surg. 20:1994;610-615.
5. Davidorf J.M., Zaldivar R., Oscherow S. Results and complications of laser in situ keratomileusis by experienced surgeons. J. Refract. Surg. 14:1998;114-122.
6. Esquenazi S., Mendoza A. Two-year follow-up of laser in situ keratomileusis for hyperopia. J. Refract. Surg. 15:1999;648-652.
7. Gao J., Gelber-Schwalb T.A., Addeo J.V., Stern M.E. Apoptosis in the rabbit cornea after photorefractive keratectomy. Cornea. 16:1997;200-208.
8. Helena M.C., Baerveldt F., Kim W.-J., Wilson S.E. Keratocyte apoptosis after corneal surgery. Invest. Ophthalmol. Vis. Sci. 39:1998;276-283.
9. Hong J.-W., Liu J.J., Lee J.-S., Mohan R.R., Mohan R.R., Woods D.J., He Y.-G., Wilson S.E. Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea. Invest. Ophthalmol. Vis. Sci. 42:2001;2795-2803.
10. Jester J.V., Moller-Pedersen T., Huang J., Sax C.M., Kays W.T., Cavangh H.D., Petroll W.M., Piatigorsky J. The cellular basis of corneal transparency: evidence for 'corneal crystallins'. J. Cell Sci. 112:1999;613-622.
11. Jester J.V., Petroll W.M., Cavanagh H.D. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog. Retin. Eye Res. 18:1999;311-356.
12. Kamiyama K., Iguchi I., Wang X., Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea. 17:1998;315-325.
13. Kapadia M.S., Wilson S.E. One-year results of PRK in low and moderate myopia: fewer than 0.5% of eyes lose two or more lines of vision. Cornea. 19:2000;180-184.
14. Kim W.-J., Helena M.C., Mohan R.R., Wilson S.E. Changes in corneal morphology associated with chronic epithelial injury. Invest. Ophthalmol. Vis. Sci. 40:1999;35-42.
15. Kim W.-J., Mohan R.R., Mohan R.R., Wilson S.E. Effect of PDGF, IL-1 alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest. Ophthalmol. Vis. Sci. 40:1999;1364-1372.
16. Kim W.-J., Mohan R.R., Mohan R.R., Wilson S.E. Caspase inhibitor z-VAD-FMK inhibits keratocyte apoptosis, but promotes keratocyte necrosis, after corneal epithelial scrape. Exp. Eye Res. 71:2000;225-232.
17. Kim J.H., Sah W.J., Park C.K., Hahn T.W., Kim M.S. Myopic regression after photorefractive keratectomy. Ophthalmic Surg. Lasers. 27:1996;S435-S439.
18. Liesegang T.J. Ocular herpes simplex infection: pathogenesis and current therapy. Mayo Clin. Proc. 63:1988;1092-1105.
19. Linna T., Tervo T. Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy. Curr. Eye Res. 16:1997;640-649.
20. Lohmann C.P., Guell J.L. Regression after LASIK for the treatment of myopia: the role of the corneal epithelium. Semin. Ophthalmol. 13:1998;79-82.
21. Lohmann C.P., Reischl U., Marshall J. Regression and epithelial hyperplasia after myopic photorefractive keratectomy in a human cornea. J. Cataract Refract. Surg. 25:1999;712-715.
22. Masur S.K., Dewal H.S., Dinh T.T., Erenburg I., Petridou S. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc. Nat. Acad. Sci. USA. 93:1996;4219-4223.
23. Mohan R.R., Kim W.-J., Mohan R.R., Chen L., Wilson S.E. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. Invest. Ophthalmol. Vis. Sci. 39:1998;2626-2636.
24. Mohan R.R., Liang Q., Kim W.-J., Helena M.C., Baerveldt F., Wilson S.E. Apoptosis in the cornea: Further characterization of Fas/Fas ligand system. Exp. Eye Res. 65:1997;575-589.
25. Mohan R.R., Mohan R.R., Kim W.J., Wilson S.E. Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kb. Invest. Ophthalmol. Vis. Sci. 41:2000;1327-1336.
26. Moller-Pedersen T., Cavanagh H.D., Petroll W.M., Jester J.V. Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea. 17:1998;627-639.
27. Moller-Pedersen T., Cavanagh H.D., Petroll W.M., Jester J.V. Neutralizing antibody to TGF beta modulates stromal fibrosis but not regression of photoablative effect following PRK. Curr. Eye Res. 17:1998;736-747.
28. Muller L.J., Pels E., Vrensen G.F. The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Br. J. Ophthalmol. 85:2001;437-443.
29. O'Brien T., Li Q., Ashraf M.F., Matteson D.M., Stark W.J., Chan C.C. Inflammatory response in the early stages of wound healing after excimer laser keratectomy. Arch. Ophthalmol. 116:1998;1470-1474.
30. Pavan-Langston D. Herpes simplex virus ocular infections: current concepts of acute, latent and reactivated disease. Trans. Am. Ophthalmol. Soc. 88:1990;727-796.
31. Reynolds E.S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17:1963;208-214.
32. Robards A.W., Wilson A.J. Procedures in Electron Microscopy. vol. 5:1993;Wiley, New York. 4.9.
33. Shah S.S., Kapadia M.S., Meisler D.M., Wilson S.E. Photorefractive keratectomy using the summit SVS Apex laser with or without astigmatic keratotomy. Cornea. 17:1998;508-516.
34. Siganos D.S., Katsanevaki V.J., Pallikaris I.G. Correlation of subepithelial haze and refractive regression 1 month after photorefractive keratectomy for myopia. J. Refract. Surg. 15:1999;338-342.
35. Spurr A.R. A low-viscosity epoxy resin embedding medium for electron microscopy. J. Ultrastruct. Res. 26:1969;31-43.
36. Williams D.K. Multizone photorefractive keratectomy for high and very high myopia: long-term results. J. Cataract Refract. Surg. 23:1997;1034-1041.
37. Wilson S.E. Keratocyte apoptosis in refractive surgery: Everett Kinsey lecture. CLAO J. 24:1998;181-185.
38. Wilson S.E. LASIK: management of common complications. Cornea. 17:1998;459-467.
39. Wilson S.E., Kaufman H.E. Penetrating keratoplasty. Surv. Ophthalmol. 34:1990;325-356.
40. Wilson S.E., Kim W.-J. Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease. Invest. Ophthalmol. Vis. Sci. 39:1998;220-226.
41. Wilson S.E., He Y.-G., Weng J., Li Q., Vital M., Chwang E.L. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization. Exp. Eye Res. 62:1996;325-338.
42. Wilson S.E., Liu J.J., Mohan R.R. Stromal-epithelial interactions in the cornea. Prog. Retinal Eye Res. 18:1999;293-309.
43. Zieske J.D., Guimaraes S.R., Hutcheon A.E. Kinetics of keratocyte proliferation in response to epithelial debridement. Exp. Eye Res. 72:2001;33-39.
44. Zieske J.D., Wasson M. Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J. Cell Sci. 106:1993;145-152.