메뉴 건너뛰기




Volumn 259, Issue 1-2, 2003, Pages 181-192

Fluorouracil prodrugs for the treatment of proliferative vitreoretinopathy: Formulation in silicone oil and in vitro release of fluorouracil

Author keywords

In vitro release of 5 fluorouracil; N1 Alkylcarbonyl 5 fluorouracil prodrugs; N1 Lauroyl 5 fluorouracil; N1 Octenoyl 5 fluorouracil; N1 Retinoyl 5 fluorouracil; Solubility in silicone oil

Indexed keywords

BUFFER; FLUOROURACIL; FLUOROURACIL DERIVATIVE; PHOSPHATE; PRODRUG; RETINOIC ACID; SILICONE OIL;

EID: 0038699623     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00232-1     Document Type: Article
Times cited : (14)

References (37)
  • 1
    • 0001433572 scopus 로고
    • Incidencia de la vitreoretinopatia proliferante (VRP) en el desprendimiento de retina regmatogeno
    • Aguirrebena A., Saornil M.A., Giraldo A., Pastor J.C. Incidencia de la vitreoretinopatia proliferante (VRP) en el desprendimiento de retina regmatogeno. Arch. Soc. Esp. Oftalmol. 51:1986;229-234.
    • (1986) Arch. Soc. Esp. Oftalmol. , vol.51 , pp. 229-234
    • Aguirrebena, A.1    Saornil, M.A.2    Giraldo, A.3    Pastor, J.C.4
  • 2
    • 0027502134 scopus 로고
    • Antiproliferative effect of retinoic acid in intravitreous silicone oil in an animal model of proliferative vitreoretinopathy
    • Araiz J.J., Refojo M.F., Arroyo M.H., Leong F.-L., Albert D.M., Tolentino F.I. Antiproliferative effect of retinoic acid in intravitreous silicone oil in an animal model of proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 34:1993;522-530.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 522-530
    • Araiz, J.J.1    Refojo, M.F.2    Arroyo, M.H.3    Leong, F.-L.4    Albert, D.M.5    Tolentino, F.I.6
  • 3
    • 0034977919 scopus 로고    scopus 로고
    • Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy. Results from a randomized, double-blind, controlled clinical trial
    • Asaria R.H.Y., Kon C.H., Bunce C., Charteris D.G., Wong D., Khaw P.T., Aylward G.W. Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy. Results from a randomized, double-blind, controlled clinical trial. Ophthalmology. 108:2001;1179-1183.
    • (2001) Ophthalmology , vol.108 , pp. 1179-1183
    • Asaria, R.H.Y.1    Kon, C.H.2    Bunce, C.3    Charteris, D.G.4    Wong, D.5    Khaw, P.T.6    Aylward, G.W.7
  • 4
    • 0029983211 scopus 로고    scopus 로고
    • 1-Alkylcarbonyl-5-fluorouracil prodrugs: Synthesis, thermal and hydrolytic stability
    • Beall H.D., Prankerd R.J., Sloan K.B. 1-Alkylcarbonyl-5-fluorouracil prodrugs: synthesis, thermal and hydrolytic stability. Drug Dev. Ind. Pharm. 22:1996;85-90.
    • (1996) Drug Dev. Ind. Pharm. , vol.22 , pp. 85-90
    • Beall, H.D.1    Prankerd, R.J.2    Sloan, K.B.3
  • 6
    • 0021048590 scopus 로고
    • Inhibition of experimental intraocular proliferation with intravitreal 5-fluorouracil
    • Binder S., Riss B., Skorpik C., Kulnig W. Inhibition of experimental intraocular proliferation with intravitreal 5-fluorouracil. Graefes Arch. Clin. Exp. Ophthalmol. 221:1983;126-129.
    • (1983) Graefes Arch. Clin. Exp. Ophthalmol. , vol.221 , pp. 126-129
    • Binder, S.1    Riss, B.2    Skorpik, C.3    Kulnig, W.4
  • 7
    • 0019966720 scopus 로고
    • Fluorouracil for the treatment of massive periretinal proliferation
    • Blumenkranz M.S., Ophir A., Claflin A.J., Hajek A. Fluorouracil for the treatment of massive periretinal proliferation. J. Ophthalmol. 94:1982;458-467.
    • (1982) J. Ophthalmol. , vol.94 , pp. 458-467
    • Blumenkranz, M.S.1    Ophir, A.2    Claflin, A.J.3    Hajek, A.4
  • 8
    • 0021142362 scopus 로고
    • Selection of therapeutic agents for intraocular proliferative disease: Cell culture evaluation
    • Blumenkranz M.S., Claflin A., Hajek A.S. Selection of therapeutic agents for intraocular proliferative disease: cell culture evaluation. Arch. Ophthalmol. 102:1984a;598-604.
    • (1984) Arch. Ophthalmol. , vol.102 , pp. 598-604
    • Blumenkranz, M.S.1    Claflin, A.2    Hajek, A.S.3
  • 9
    • 0021360271 scopus 로고
    • 5-Fluorouracil: New applications in complicated retinal detachment for an established antimetabolite
    • Blumenkranz M., Hernandez E., Ophir A., Norton E.W.D. 5-Fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology. 91:1984b;122-130.
    • (1984) Ophthalmology , vol.91 , pp. 122-130
    • Blumenkranz, M.1    Hernandez, E.2    Ophir, A.3    Norton, E.W.D.4
  • 10
    • 0021187201 scopus 로고
    • Prodrugs of 5-fluorouracil. I. Hydrolysis kinetics and physicochemical properties of various N-acyl derivatives of 5-fluorouracil
    • Buur A., Bundgaard H. Prodrugs of 5-fluorouracil. I. Hydrolysis kinetics and physicochemical properties of various N-acyl derivatives of 5-fluorouracil. Int. J. Pharm. 21:1984;349-364.
    • (1984) Int. J. Pharm. , vol.21 , pp. 349-364
    • Buur, A.1    Bundgaard, H.2
  • 11
    • 0038023442 scopus 로고    scopus 로고
    • Effects of epidermal growth factor, basic fibroblast growth factor and 5-fluorouracil on human retinal pigment epithelial wound closure in vitro
    • (in Chinese)
    • Chen M., Lan P., Gao M. Effects of epidermal growth factor, basic fibroblast growth factor and 5-fluorouracil on human retinal pigment epithelial wound closure in vitro. Chung Hua Yen Ko Tsa Chih. 35:1999;134-136. (in Chinese).
    • (1999) Chung Hua Yen Ko Tsa Chih , vol.35 , pp. 134-136
    • Chen, M.1    Lan, P.2    Gao, M.3
  • 12
    • 0026705691 scopus 로고
    • Factors modulating the effect of retinoids on cultured retinal pigment epithelial cell proliferation
    • Doyle J.W., Dowgiert R.K., Buzney S.M. Factors modulating the effect of retinoids on cultured retinal pigment epithelial cell proliferation. Curr. Eye Res. 11:1992;753-765.
    • (1992) Curr. Eye Res. , vol.11 , pp. 753-765
    • Doyle, J.W.1    Dowgiert, R.K.2    Buzney, S.M.3
  • 13
    • 0028911038 scopus 로고
    • The effect of oral 13-cis-retinoic acid on retinal detachment after surgical repair in eyes with proliferative vitreoretinopathy
    • Fekrat S., de Juan E., Campochiaro P.A. The effect of oral 13-cis-retinoic acid on retinal detachment after surgical repair in eyes with proliferative vitreoretinopathy. Ophthalmology. 102:1995;412-418.
    • (1995) Ophthalmology , vol.102 , pp. 412-418
    • Fekrat, S.1    De Juan, E.2    Campochiaro, P.A.3
  • 14
    • 0027240653 scopus 로고
    • Sustained delivery of retinoic acid from microspheres of biodegradable polymer in PVR
    • Giordano G.G., Refojo M.F., Arroyo M.H. Sustained delivery of retinoic acid from microspheres of biodegradable polymer in PVR. Invest. Ophthalmol. Vis. Sci. 34:1993;2743-2751.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 2743-2751
    • Giordano, G.G.1    Refojo, M.F.2    Arroyo, M.H.3
  • 15
    • 0035980341 scopus 로고    scopus 로고
    • Biodegradable microspheres for vitreoretinal drug delivery
    • Herrero-Vanrell R., Refojo M.F. Biodegradable microspheres for vitreoretinal drug delivery. Adv. Drug Deliv. Rev. 52:2001;5-16.
    • (2001) Adv. Drug Deliv. Rev. , vol.52 , pp. 5-16
    • Herrero-Vanrell, R.1    Refojo, M.F.2
  • 16
    • 0022006067 scopus 로고
    • Clearance of intravitreal fluorouracil. Normal and aphakic vitrectomized eyes
    • Jarus G., Blumenkranz M., Hernandez E., Sossi N. Clearance of intravitreal fluorouracil. Normal and aphakic vitrectomized eyes. Ophthalmology. 92:1985;91-96.
    • (1985) Ophthalmology , vol.92 , pp. 91-96
    • Jarus, G.1    Blumenkranz, M.2    Hernandez, E.3    Sossi, N.4
  • 18
    • 0034332544 scopus 로고    scopus 로고
    • Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs
    • Martino R., Malet-Martino M., Gilard V. Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs. Curr. Drug Metab. 1:2000;271-303.
    • (2000) Curr. Drug Metab. , vol.1 , pp. 271-303
    • Martino, R.1    Malet-Martino, M.2    Gilard, V.3
  • 19
    • 0023855387 scopus 로고
    • Application of fluorine-19 nuclear magnetic resonance to the determination of plasma-protein binding of 5′-deoxy-5-fluorouridine, a new antineoplastic fluoropyrimidine
    • Meynial D., Lopez A., Malet-Martino M., Hoffmann J.S., Martino R. Application of fluorine-19 nuclear magnetic resonance to the determination of plasma-protein binding of 5′-deoxy-5-fluorouridine, a new antineoplastic fluoropyrimidine. J. Pharm. Biomed. Anal. 6:1988;47-59.
    • (1988) J. Pharm. Biomed. Anal. , vol.6 , pp. 47-59
    • Meynial, D.1    Lopez, A.2    Malet-Martino, M.3    Hoffmann, J.S.4    Martino, R.5
  • 20
    • 0028841471 scopus 로고
    • Onset and recurrence of proliferative vitreoretinopathy in various vitreoretinal diseases
    • Mietz H., Heimann K. Onset and recurrence of proliferative vitreoretinopathy in various vitreoretinal diseases. Br. J. Ophthalmol. 79:1995;874-877.
    • (1995) Br. J. Ophthalmol. , vol.79 , pp. 874-877
    • Mietz, H.1    Heimann, K.2
  • 22
    • 0028823369 scopus 로고
    • Retinoic acid in silicone and silicone-fluorosilicone copolymer oils in a rabbit model of proliferative vitreoretinopathy
    • Nakagawa M., Refojo M.F., Marin J.F., Doi M., Tolentino F.I. Retinoic acid in silicone and silicone-fluorosilicone copolymer oils in a rabbit model of proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 36:1995;2388-2395.
    • (1995) Invest. Ophthalmol. Vis. Sci. , vol.36 , pp. 2388-2395
    • Nakagawa, M.1    Refojo, M.F.2    Marin, J.F.3    Doi, M.4    Tolentino, F.I.5
  • 23
    • 0025776040 scopus 로고
    • Further observations on the prevention of experimental proliferative vitreoretinopathy by 5-fluorouracil
    • Ophir A. Further observations on the prevention of experimental proliferative vitreoretinopathy by 5-fluorouracil. Ophthalmic Res. 23:1991;128-132.
    • (1991) Ophthalmic Res. , vol.23 , pp. 128-132
    • Ophir, A.1
  • 24
    • 0032128359 scopus 로고    scopus 로고
    • Proliferative vitreoretinopathy: An overview
    • Pastor J.C. Proliferative vitreoretinopathy: an overview. Surv. Ophtalmol. 43:1998;3-18.
    • (1998) Surv. Ophtalmol. , vol.43 , pp. 3-18
    • Pastor, J.C.1
  • 26
    • 0034530815 scopus 로고    scopus 로고
    • Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye
    • Perkins S.L., Gallemore R.P., Yang C.H., Guo H., Ashton P., Jaffe G.J. Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye. Retina. 20:2000;514-519.
    • (2000) Retina , vol.20 , pp. 514-519
    • Perkins, S.L.1    Gallemore, R.P.2    Yang, C.H.3    Guo, H.4    Ashton, P.5    Jaffe, G.J.6
  • 27
    • 0028281483 scopus 로고
    • Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil
    • Rubsamen P.E., Davis P.A., Hernandez E., O'Grady G.E., Cousins S.W. Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. Arch. Ophthalmol. 112:1994;407-413.
    • (1994) Arch. Ophthalmol. , vol.112 , pp. 407-413
    • Rubsamen, P.E.1    Davis, P.A.2    Hernandez, E.3    O'Grady, G.E.4    Cousins, S.W.5
  • 28
    • 0029975363 scopus 로고    scopus 로고
    • Intraocular drug delivery. In vitro release studies of 5-fluorouracil from N1-alkoxycarbonyl prodrugs in silicone oil
    • Steffansen B., Ashton P., Buur A. Intraocular drug delivery. In vitro release studies of 5-fluorouracil from N1-alkoxycarbonyl prodrugs in silicone oil. Int. J. Pharm. 132:1996;243-250.
    • (1996) Int. J. Pharm. , vol.132 , pp. 243-250
    • Steffansen, B.1    Ashton, P.2    Buur, A.3
  • 31
    • 0021330857 scopus 로고
    • Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model
    • Sunalp M., Wiedemann P., Sorgente N., Ryan S.J. Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model. Curr. Eye Res. 3:1984;619-623.
    • (1984) Curr. Eye Res. , vol.3 , pp. 619-623
    • Sunalp, M.1    Wiedemann, P.2    Sorgente, N.3    Ryan, S.J.4
  • 32
    • 0030796730 scopus 로고    scopus 로고
    • Antiproliferative effect of retinoic acid in 1% sodium hyaluronate in an animal model of PVR
    • Takahashi M., Refojo M.F., Nakagawa M., Veloso A., Leong F.-L. Antiproliferative effect of retinoic acid in 1% sodium hyaluronate in an animal model of PVR. Curr. Eye Res. 16:1997;703-709.
    • (1997) Curr. Eye Res. , vol.16 , pp. 703-709
    • Takahashi, M.1    Refojo, M.F.2    Nakagawa, M.3    Veloso, A.4    Leong, F.-L.5
  • 33
    • 0343812078 scopus 로고    scopus 로고
    • 13-cis-Retinoic acid in silicone-fluorosilicone copolymer oil in a rabbit model of proliferative vitreoretinopathy
    • Veloso A.A.S., Kadrmas E.F., Larrosa J.M., Sandberg M.A., Tolentino F.I., Refojo M.F. 13-cis-Retinoic acid in silicone-fluorosilicone copolymer oil in a rabbit model of proliferative vitreoretinopathy. Exp. Eye Res. 65:1997;425-434.
    • (1997) Exp. Eye Res. , vol.65 , pp. 425-434
    • Veloso, A.A.S.1    Kadrmas, E.F.2    Larrosa, J.M.3    Sandberg, M.A.4    Tolentino, F.I.5    Refojo, M.F.6
  • 34
    • 0024716284 scopus 로고
    • Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics
    • Viswanadhan V.N., Ghose A.K., Revankar G.R., Robins R.K. Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics. J. Chem. Inf. Comput. Sci. 29:1989;163-172.
    • (1989) J. Chem. Inf. Comput. Sci. , vol.29 , pp. 163-172
    • Viswanadhan, V.N.1    Ghose, A.K.2    Revankar, G.R.3    Robins, R.K.4
  • 35
    • 0027216907 scopus 로고
    • A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring
    • Ward T., Hartzer M., Blumenkranz M., Lin L.-R. A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring. Curr. Eye Res. 12:1993;397-401.
    • (1993) Curr. Eye Res. , vol.12 , pp. 397-401
    • Ward, T.1    Hartzer, M.2    Blumenkranz, M.3    Lin, L.-R.4
  • 37
    • 0031909516 scopus 로고    scopus 로고
    • An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy
    • Yang C.-S., Khawly J.A., Hainsworth D.P., Chen S.-N., Ashton P., Guo H., Jaffe G.J. An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. Arch. Ophthalmol. 116:1998;69-77.
    • (1998) Arch. Ophthalmol. , vol.116 , pp. 69-77
    • Yang, C.-S.1    Khawly, J.A.2    Hainsworth, D.P.3    Chen, S.-N.4    Ashton, P.5    Guo, H.6    Jaffe, G.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.