L-arginine: An amino acid with multiple effects;L-arginin: Eine aminosäure mit multiplen wirkungen

Wiener Klinische Wochenschrift

Volumn 117, Issue 19-20, 2005, Pages 666-672

  Roth, Erich ^a   Wessner, Barbara ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Clinical nutrition; Endothelial function; Immunonutrition; Infusion therapy; L arginine; NO; Organ function; Sepsis

Indexed keywords

AMINO ACID; ARGININE; BUNITROLOL;

AMINO ACID METABOLISM; ASTHMA; FERTILITY; HYPERAMMONEMIA; IMPACT; NEUROPROTECTION; RESPIRATORY DISTRESS; REVIEW; SEPSIS; SEXUALITY;

ARGININE; ASTHMA; BODY CONSTITUTION; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; FRACTURE HEALING; HUMANS; NEOPLASMS;

EID: 28344448741     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-005-0457-1     Document Type: Review

References (52)

1. Palmer RM, Ashton DS, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664-666
2. Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526
3. Wu G, Meininger CJ, Knabe DA, Bazer FW, Rhoads JM (2000) Arginine nutrition in development, health and disease. Curr Opin Clin Nutr Metab Care 3: 59-66
4. Holt LE Jr, Albanese AA (1944) Observations on amino acid deficiencies in man. Trans Assoc Am Physician 58: 143-156
5. Tanimura J (1967) Studies on arginine in human semen. Part II. The effects of medication with L-arginine-HCl on male infertility. Bull Osaka Med School 13: 84-89
6. Chen J, Wollman Y, Chernikovsky T, Iaina A, et al (1999) Effect of oral administration of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int 83: 269-273
7. Rosselli M, Keller PJ, Dubey RK (1998) Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Human Reprod Update 4: 3-24
8. Efron DT, Barbul A (1998) Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care 1: 531-538
9. Wilmore D (2004) Enteral and parenteral arginine supplementation to improve medical outcomes in hospitalized patients. J Nutr 134: 2863S-2867S
10. Ochoa JB, Bernard AC, Mistry SK, Morris SM Jr, et al (2000) Trauma increases extrahepatic arginase activity. Surgery 127: 419-426
11. Ochoa JB, Bernard AC, O'Brien WE, et al (2001) Arginase I expression and activity in human mononuclear cells after injury. Ann Surg 233: 393-399
12. Barksdale AR, Bernard AC, Maley ME, et al (2004) Regulation of arginase expression by T-helper II cytokines and isoproterenol. Surgery 135: 527-535
13. Kdolsky RK, Mohr W, Savidis-Dacho H, et al (2005) The influence of orally administered L-arginine on fracture healing: an animal study. Wien Klin Wochenschr 117: 693-701
14. Chow JWM, Fox SW, Lean JM, Chamber TJ (1998) Role of nitric oxide and prostaglandins in mechanically induced bone formation. J Bone Miner Res 13: 1039-1044
15. Brosnan ME, Brosnan JT (2004) Renal arginine metabolism. J Nutr 134: 2791S-2795S
16. Cherla G, Jaimes EA (2004) Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr 134: 2801S-2806S
17. Schramm L, La M, Heidbreder E, et al (2002) L-Arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int 61: 1423-1432
18. Huk I, Nanobashvili J, Neumayer C, et al (1997) L-Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 96: 667-675
19. Roth E (1998) The impact of L-arginine-nitric oxide metabolism on ischemia/reperfusion injury. Curr Opin Clin Nutr Metab Care 1: 97-99
20. Gornik HL, Creager MA (2004) Arginine and endothelial and vascular health. J Nutr 134: 2880S-2887S
21. Cannon RO III (2002) Oral L-arginine (and other active ingredients) for ischemic heart disease? J Am Coll Card 39: 46-48
22. Loscalzo J (2004) L-Arginine and atherothrombosis. J Nutr 134: 2798S-2800S
23. Gokce N (2004) L-Arginine and hypertension. J Nutr 134: 2807S-2811S
24. Böger RH (2004) Asymmetric dimethylarginine, and endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor. J Nutr 134: 2842S-2847S
25. Nijveldt RJ, Siroen MPC, Teerlink T, van Leeuwen PAM (2004) Elimination of asymmetric dimethylarginine by the kidney and the liver: a link to the development of multiple organ failure? J Nutr 134: 2848S-2852S
26. Lange PS, Langley B, Peiyuan L, Ratan RR (2004) Novel roles for arginase in cell survival, regeneration, and translation in the central nervous system. J Nutr 134: 2812S-2817S
27. King NE, Rothenberg ME, Zimmermann N (2004) Arginine in asthma and lung inflammation. J Nutr 134: 2830S-2836S
28. Roth E (2004) Parenterale und enterale Immunonutrition. Chir Gastroenterol 20: 210-215
29. Heyland DK, Dhaliwal R, Drover JW, et al (2003) Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN 27: 356-378
30. Luiking YC, Poeze M, Dejong CH, et al (2004) Sepsis: an arginine deficiency state? Crit Care Med 32: 2135-2145
31. Lopez A, Lorente JA, Steingrub J, et al (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32: 21-30
32. Rudkovski JC, Barreiro E, Harfouche R, et al (2004) Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol 286: L793-L800
33. Price S, Mitchell JA, Anning PB, Evans TW (2003) Type II nitric oxide synthase activity is cardio-protective in experimental sepsis. Eur J Pharmacol 472: 111-118
34. Deutz NEP: Vortrag ESPEN-Kongress, Lissabon 2004
35. Bruins MJ, Luiking YC, Soeters PB, et al (2004) Effects of long-term intravenous and intragastric L-arginine intervention on jejunal motility and visceral nitric oxide production in the hyperdynamic compensated endotoxaemic pig. Neurogastroenterol Motil 16: 819-828
36. Sheridan BC, McIntyre RC, Meldrum R, Fullerton DA (1998) L-Arginine prevents lung neutrophil accumulation and preserved pulmonary endothelial function after endotoxin. Am J Physiol 274 (Lung Cell Mol Physiol 18): L337-L342
37. Angele MK, Fitzal F, Smail N, et al (2000) L-Arginine attenuated trauma-hemorrhages-induced liver injury. Crit Care Med 28: 3242-3248
38. Suschek CV, Schnorr O, Hemmrich K, et al (2003) Critical role of L-arginine in endothelial cell survival during oxidative stress. Circulation 107: 2607-2614
39. Pastor C, Teisseire B, Vicaut E, Payen D (1994) Effects of L-arginine and L-nitro-arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model. Crit Care Med 22: 465-469
40. Marik PE (2003) Cardiovascular dysfunction of sepsis: a nitric oxide- and 1-arginine-deficient state? Crit Care Med 31: 971-973
41. Carcillo J (2003) Does arginine become a near essential amino acid during sepsis? Crit Care Med 31: 657-659
42. Traber DL (2002) Arginine in shock, trauma, and sepsis. Crit Care Med 30: 705-706
43. Roth E (2004) Immunonutrition: back to science. JPEN 28: 278
44. Bertolini G, Iapichino G, Radrizzani D, et al (2003) Early enteral immunonutrition in patients with severe sepsis. Results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med 29: 834-840
45. Montejo JC, Zarazaga A, López-Martínez J, et al (2003) Immunonutrition in the intensive care unit. A systematic review and consensus statement. Clin Nutr 22: 221-233
46. Heyland DK, Novak F, Drover JW, et al (2001) Should immunonutrition become routine in critically ill patients? JAMA 286: 944-953
47. Keys SD, Walker LG, Smith I, Eremin O (1999) Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. Ann Surg 229: 467-477
48. Lind DS (2004) Arginine and cancer. J Nutr 134: 2837-2841
49. Lieberman MD, Nishioka K, Redmond BP, Daly JM (1992) Enhancement of interleukin-immunotherapy with L-arginine. Ann Surg 215: 157-165
50. Barbul A, Lazarou SA, Efron DT, et al (1990) Arginine enhanced wound healing and lymphocyte immune responses in humans. Surgery 108: 331-336
51. Kirk SJ, Hurson M, Regan MC, et al (1993) Arginine stimulates wound healing and immune function in elderly human beings. Surgery 114: 155-159
52. Beaumier L, Castillo L, Ajami AM, Young VR (1995) Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in human. Am J Physiol 269: E884-E896