-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's Disease: Progress and problems on the road to therapeutics
-
Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's Disease: Progress and problems on the road to therapeutics, Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0036548070
-
y-Secretase, notch, Aβ and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia, S. S., and St George-Hyslop, P. H. (2002) y-Secretase, notch, Aβ and Alzheimer's disease: Where do the presenilins fit in? Nat. Rev. Neurosci. 3, 281-290.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
3
-
-
0036855661
-
Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease
-
Selkoe, D. J. (2002) Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease, J. Clin. Invest. 110, 1375-1381.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1375-1381
-
-
Selkoe, D.J.1
-
4
-
-
0033968306
-
Molecular genetics of Alzheimer's disease
-
St George-Hyslop, P. H. (2000) Molecular genetics of Alzheimer's disease, Biol. Psychol. 47, 183-199.
-
(2000)
Biol. Psychol.
, vol.47
, pp. 183-199
-
-
St George-Hyslop, P.H.1
-
5
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy, J. (1997) Amyloid, the presenilins and Alzheimer's disease, Trends Neurosci. 20, 154-159.
-
(1997)
Trends Neurosci.
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
6
-
-
0043198120
-
BACE-2 is overexpressed in Down's syndrome
-
Barbiero, L., Benussi, L., Ghidoni, R., Alberici, A., Russo, C., Schettini, G., Pagano, S. F., Parati, E. A., Mazzoli, F., Nicosia, F., Signorini, S., Feudatari, E., and Binetti, G. (2003) BACE-2 is overexpressed in Down's syndrome, Exp. Neurol. 182, 335-345.
-
(2003)
Exp. Neurol.
, vol.182
, pp. 335-345
-
-
Barbiero, L.1
Benussi, L.2
Ghidoni, R.3
Alberici, A.4
Russo, C.5
Schettini, G.6
Pagano, S.F.7
Parati, E.A.8
Mazzoli, F.9
Nicosia, F.10
Signorini, S.11
Feudatari, E.12
Binetti, G.13
-
7
-
-
4744370969
-
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: Insight from transgenic mouse and tissue-culture models
-
Gotz, J., Schild, A., Hoerndli, F., and Pennanen, L. (2004) Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: Insight from transgenic mouse and tissue-culture models, Int. J. Dev. Neurosci. 22, 453-465.
-
(2004)
Int. J. Dev. Neurosci.
, vol.22
, pp. 453-465
-
-
Gotz, J.1
Schild, A.2
Hoerndli, F.3
Pennanen, L.4
-
8
-
-
0033888999
-
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease
-
Stoltzner, S. E., Grenfell, T. J., Mon, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., and Lemere, C. A. (2000) Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease, Am. J. Pathol. 156, 489-499.
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 489-499
-
-
Stoltzner, S.E.1
Grenfell, T.J.2
Mon, C.3
Wisniewski, K.E.4
Wisniewski, T.M.5
Selkoe, D.J.6
Lemere, C.A.7
-
9
-
-
0024343222
-
Cerebral amyloidosis, ageing and Alzheimer's disease: A contribution from studies on Down's syndrome
-
Mann, D. M. (1989) Cerebral amyloidosis, ageing and Alzheimer's disease: A contribution from studies on Down's syndrome, Neurobiol. Aging 10, 397-399.
-
(1989)
Neurobiol. Aging
, vol.10
, pp. 397-399
-
-
Mann, D.M.1
-
10
-
-
0030725311
-
Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer's disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability
-
Castillo, G. M., Ngo, C., Cummings, J., Wight, T. N., and Snow, A. D. (1997) Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer's disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability, J. Neurochem. 69, 2452-2465.
-
(1997)
J. Neurochem.
, vol.69
, pp. 2452-2465
-
-
Castillo, G.M.1
Ngo, C.2
Cummings, J.3
Wight, T.N.4
Snow, A.D.5
-
11
-
-
0024273721
-
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
-
Snow, A. D., Mar, H., Nochlin, D., Kimata, K., Kato, M., Suzuki, S., Hassell, J., and Wight, T. N. (1988) The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease, Am. J. Pathol. 133, 456-463.
-
(1988)
Am. J. Pathol.
, vol.133
, pp. 456-463
-
-
Snow, A.D.1
Mar, H.2
Nochlin, D.3
Kimata, K.4
Kato, M.5
Suzuki, S.6
Hassell, J.7
Wight, T.N.8
-
12
-
-
0029417189
-
Multivalent binding of complement protein C1Q to the amyloid β-peptide (Aβ) promotes the nucleation phase of Aβ aggregation
-
Webster, S., Glabe, C., and Rogers, J. (1995) Multivalent binding of complement protein C1Q to the amyloid β-peptide (Aβ) promotes the nucleation phase of Aβ aggregation, Biochem. Biophys. Res. Commun. 217, 869-875.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.217
, pp. 869-875
-
-
Webster, S.1
Glabe, C.2
Rogers, J.3
-
13
-
-
0025971426
-
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
-
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., and Ikeda, K. (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease, Brain Res. 541, 163-166.
-
(1991)
Brain Res.
, vol.541
, pp. 163-166
-
-
Namba, Y.1
Tomonaga, M.2
Kawasaki, H.3
Otomo, E.4
Ikeda, K.5
-
14
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
-
Gomez-Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., and Hyman, B. T. (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease, Ann. Neural. 41, 17-24.
-
(1997)
Ann. Neural.
, vol.41
, pp. 17-24
-
-
Gomez-Isla, T.1
Hollister, R.2
West, H.3
Mui, S.4
Growdon, J.H.5
Petersen, R.C.6
Parisi, J.E.7
Hyman, B.T.8
-
15
-
-
2542502430
-
ApoE genotype accounts for the vast majority of AD risk and AD pathology
-
Raber, J., Huang, Y., and Ashford, J. W. (2004) ApoE genotype accounts for the vast majority of AD risk and AD pathology, Neurobiol. Aging 25, 641-650.
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 641-650
-
-
Raber, J.1
Huang, Y.2
Ashford, J.W.3
-
16
-
-
0037100183
-
Differential distribution of laminins in Alzheimer disease and normal human brain tissue
-
Palu, E., and Liesi, P. (2002) Differential distribution of laminins in Alzheimer disease and normal human brain tissue, J. Neurosci. Res. 69, 243-256.
-
(2002)
J. Neurosci. Res.
, vol.69
, pp. 243-256
-
-
Palu, E.1
Liesi, P.2
-
17
-
-
4143138471
-
In vivo effects of ApoE and clusterin on amyloid-β metabolism and neuropathology
-
Holtzman, D. M. (2004) In vivo effects of ApoE and clusterin on amyloid-β metabolism and neuropathology, J. Mol. Neurosci. 23, 247-254.
-
(2004)
J. Mol. Neurosci.
, vol.23
, pp. 247-254
-
-
Holtzman, D.M.1
-
18
-
-
18444418272
-
CLAC: A novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV
-
Hashimoto, T., Wakabayashi, T., Watanabe, A., Kowa, H., Hosoda, R., Nakamura, A., Kanazawa, I., Arai, T., Takio, K., Mann, D. M., and Iwatsubo, T. (2002) CLAC: A novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV, EMBO J. 21, 1524-1534.
-
(2002)
EMBO J
, vol.21
, pp. 1524-1534
-
-
Hashimoto, T.1
Wakabayashi, T.2
Watanabe, A.3
Kowa, H.4
Hosoda, R.5
Nakamura, A.6
Kanazawa, I.7
Arai, T.8
Takio, K.9
Mann, D.M.10
Iwatsubo, T.11
-
19
-
-
0032786710
-
Spatial relationship of AMY protein deposits and different species of Aβ peptides in amyloid plaques of the Alzheimer disease brain
-
Schmidt, M. L., Saldo, T. C., Lee, V. M., and Trojanowski, J. Q. (1999) Spatial relationship of AMY protein deposits and different species of Aβ peptides in amyloid plaques of the Alzheimer disease brain, J. Neuropathol. Exp. Neurol. 58, 1227-1233.
-
(1999)
J. Neuropathol. Exp. Neurol.
, vol.58
, pp. 1227-1233
-
-
Schmidt, M.L.1
Saldo, T.C.2
Lee, V.M.3
Trojanowski, J.Q.4
-
20
-
-
0033055648
-
The AMY antigen co-occurs with Aβ and follows its deposition in the amyloid plaques of Alzheimer's disease and Down syndrome
-
Lemere, C. A., Grenfell, T. J., and Selkoe, D. J. (1999) The AMY antigen co-occurs with Aβ and follows its deposition in the amyloid plaques of Alzheimer's disease and Down syndrome, Am. J. Pathol. 155, 29-37.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 29-37
-
-
Lemere, C.A.1
Grenfell, T.J.2
Selkoe, D.J.3
-
21
-
-
0242440879
-
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein
-
Söderberg, L., Zhukareva, V., Bogdanovic, N., Hashimoto, T., Winblad, B., Iwatsubo, T., Lee, V. M., Trojanowski, J. Q., and Näslund, J. (2003) Molecular identification of AMY, an Alzheimer disease amyloid-associated protein, J. Neuropathol. Exp. Neurol. 62, 1108-1117.
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 1108-1117
-
-
Söderberg, L.1
Zhukareva, V.2
Bogdanovic, N.3
Hashimoto, T.4
Winblad, B.5
Iwatsubo, T.6
Lee, V.M.7
Trojanowski, J.Q.8
Näslund, J.9
-
22
-
-
14244264636
-
Collagenous transmembrane proteins: Recent insights into biology and pathology
-
Franzke, C.-W., Bruckner, P., and Bruckner-Tuderman, L. (2005) Collagenous transmembrane proteins: Recent insights into biology and pathology, J. Biol. Chem. 280, 4005-4008.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4005-4008
-
-
Franzke, C.-W.1
Bruckner, P.2
Bruckner-Tuderman, L.3
-
23
-
-
3042643601
-
Mostly separate distributions of CLAC- Versus Aβ40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of β-amyloid deposits
-
Kowa, H., Sakakura, T., Matsuura, Y., Wakabayashi, T., Mann, D. M., Duff, K., Tsuji, S., Hashimoto, T., and Iwatsubo, T. (2004) Mostly separate distributions of CLAC- versus Aβ40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of β-amyloid deposits, Am. J. Pathol. 165, 273-281.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 273-281
-
-
Kowa, H.1
Sakakura, T.2
Matsuura, Y.3
Wakabayashi, T.4
Mann, D.M.5
Duff, K.6
Tsuji, S.7
Hashimoto, T.8
Iwatsubo, T.9
-
24
-
-
14844335677
-
CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagen domain 1 and inhibits formation of amyloid fibrils
-
Osada, Y., Hashimoto, T., Nishimura, A., Matsuo, Y., Wakabayashi, T., and Iwatsubo, T. (2005) CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagen domain 1 and inhibits formation of amyloid fibrils, J. Biol. Chem. 280, 8596-8605.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8596-8605
-
-
Osada, Y.1
Hashimoto, T.2
Nishimura, A.3
Matsuo, Y.4
Wakabayashi, T.5
Iwatsubo, T.6
-
25
-
-
18444368124
-
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
-
Söderberg, L., Dahlqvist, C., Kakuyama, H., Thyberg, J., Ito, A., Winblad, B., Näslund, J., and Tjernberg, L. O. (2005) Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates, FEBS J. 272, 2231-2236.
-
(2005)
FEBS J.
, vol.272
, pp. 2231-2236
-
-
Söderberg, L.1
Dahlqvist, C.2
Kakuyama, H.3
Thyberg, J.4
Ito, A.5
Winblad, B.6
Näslund, J.7
Tjernberg, L.O.8
-
26
-
-
15844369794
-
Surface plasmon resonance for the analysis of β-amyloid interactions and fibril formation in Alzheimer's disease research
-
Aguilar, M. I., and Small, D. H. (2005) Surface plasmon resonance for the analysis of β-amyloid interactions and fibril formation in Alzheimer's disease research, Neurotoxic. Res. 7, 17-27.
-
(2005)
Neurotoxic. Res.
, vol.7
, pp. 17-27
-
-
Aguilar, M.I.1
Small, D.H.2
-
27
-
-
12544257973
-
Characterization of the Alzheimer's Disease-associated CLAC protein and identification of an amyloid β-peptide-biriding site
-
Söderberg, L., Kakuyama, H., Moller, A., Ito, A., Winblad, B., Tjernberg, L. O., and Näslund, J. (2005) Characterization of the Alzheimer's Disease-associated CLAC protein and identification of an amyloid β-peptide-biriding site, J. Biol. Chem. 280, 1007-1015.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1007-1015
-
-
Söderberg, L.1
Kakuyama, H.2
Moller, A.3
Ito, A.4
Winblad, B.5
Tjernberg, L.O.6
Näslund, J.7
-
28
-
-
0030978135
-
Charge-based binding of complement component C1q to the Alzheimer amyloid β-peptide
-
Webster, S., Bonnell, B., and Rogers, J. (1997) Charge-based binding of complement component C1q to the Alzheimer amyloid β-peptide, Am. J. Pathol. 150, 1531-1536.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1531-1536
-
-
Webster, S.1
Bonnell, B.2
Rogers, J.3
-
29
-
-
0029994633
-
Arrest of β-amyloid fibril formation by a pentapeptide ligand
-
Tjernberg, L. O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A. R., Thyberg, J., Terenius, L., and Nordstedt, C. (1996) Arrest of β-amyloid fibril formation by a pentapeptide ligand, J. Biol. Chem. 271, 8545-8548.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8545-8548
-
-
Tjernberg, L.O.1
Näslund, J.2
Lindqvist, F.3
Johansson, J.4
Karlström, A.R.5
Thyberg, J.6
Terenius, L.7
Nordstedt, C.8
-
30
-
-
0033617220
-
A molecular model of Alzheimer amyloid β-peptide fibril formation
-
Tjernberg, L. O., Callaway, D. J., Tjernberg, A., Hahne, S., Lilliehöök, C., Terenius, L., Thyberg, J., and Nordstedt, C. (1999) A molecular model of Alzheimer amyloid β-peptide fibril formation, J. Biol. Chem. 274, 12619-12625.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12619-12625
-
-
Tjernberg, L.O.1
Callaway, D.J.2
Tjernberg, A.3
Hahne, S.4
Lilliehöök, C.5
Terenius, L.6
Thyberg, J.7
Nordstedt, C.8
-
31
-
-
0037103821
-
Assembling amyloid fibrils from designed structures containing a significant amyloid β-peptide
-
Tjernberg, L. O., Tjernberg, A., Bark, N., Shi, Y., Ruzsicska, B. P., Bu, Z., Thyberg, J., and Callaway, D. J. (2002) Assembling amyloid fibrils from designed structures containing a significant amyloid β-peptide, Biochem. J. 366, 343-351.
-
(2002)
Biochem. J.
, vol.366
, pp. 343-351
-
-
Tjernberg, L.O.1
Tjernberg, A.2
Bark, N.3
Shi, Y.4
Ruzsicska, B.P.5
Bu, Z.6
Thyberg, J.7
Callaway, D.J.8
-
32
-
-
1842686289
-
Kinetic analysis of β-amyloid fibril elongation
-
Cannon, M. J., Williams, A. D., Wetzel, R., and Myszka, D. G. (2004) Kinetic analysis of β-amyloid fibril elongation, Anal. Biochem. 328, 67-75.
-
(2004)
Anal. Biochem.
, vol.328
, pp. 67-75
-
-
Cannon, M.J.1
Williams, A.D.2
Wetzel, R.3
Myszka, D.G.4
-
33
-
-
0037137225
-
Kinetic modeling and determination of reaction constants of Alzheimer's β-amyloid fibril extension and dissociation using surface plasmon resonance
-
Hasegawa, K., Ono, K., Yamada, M., and Naiki, H. (2002) Kinetic modeling and determination of reaction constants of Alzheimer's β-amyloid fibril extension and dissociation using surface plasmon resonance, Biochemistry 41, 13489-1398.
-
(2002)
Biochemistry
, vol.41
, pp. 13489-21398
-
-
Hasegawa, K.1
Ono, K.2
Yamada, M.3
Naiki, H.4
-
34
-
-
0029938009
-
Interaction between human amphipathic apolipoproteins and amyloid β-peptide: Surface plasmon resonance studies
-
Shuvaev, V. V., and Siest, G. (1996) Interaction between human amphipathic apolipoproteins and amyloid β-peptide: Surface plasmon resonance studies, FEBS Lett. 383, 9-12.
-
(1996)
FEBS Lett.
, vol.383
, pp. 9-12
-
-
Shuvaev, V.V.1
Siest, G.2
-
35
-
-
0028920098
-
Prolines and amyloidogenicity in fragments of the Alzheimer's peptide βIA4
-
Wood, S. J., Wetzel, R., Martin, J. D., and Hurle, M. R. (1995) Prolines and amyloidogenicity in fragments of the Alzheimer's peptide βIA4, Biochemistry 34, 724-730.
-
(1995)
Biochemistry
, vol.34
, pp. 724-730
-
-
Wood, S.J.1
Wetzel, R.2
Martin, J.D.3
Hurle, M.R.4
-
36
-
-
18944407388
-
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death
-
Wogulis, M., Wright, S., Cunningham, D., Chilcote, T., Powell, K., and Rydel, R. E. (2005) Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death, J. Neurosci. 25, 1071-1080.
-
(2005)
J. Neurosci.
, vol.25
, pp. 1071-1080
-
-
Wogulis, M.1
Wright, S.2
Cunningham, D.3
Chilcote, T.4
Powell, K.5
Rydel, R.E.6
|