The inhibition of cathepsin S by its propeptide. Specificity and mechanism of action

European Journal of Biochemistry

Volumn 250, Issue 3, 1997, Pages 745-750

  Maubach, Gunter ^a   Schilling, Klaus ^a   Rommerskirch, Winfried ^a   Wenz, Ingrid ^a   Schultz, Joachim E ^b   Weber, Ekkehard ^c   Wiederanders, Bernd ^a,d  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d Institut für Biochemie I   (Germany)

Author keywords

Cathepsin S; Circular dichroism; Cysteine protease; Inhibition kinetics; Propeptide

Indexed keywords

CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE;

ARTICLE; CIRCULAR DICHROISM; ENZYME SPECIFICITY; HUMAN; INHIBITION KINETICS; PARAMECIUM TETRAURELIA; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE;

PARAMECIUM TETRAURELIA;

EID: 0031574214     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00745.x     Document Type: Article

References (26)

1. Baker, D., Silen, J. L. & Agard, D. A. (1992) Protease pro region required for folding is a potent inhibitor of the mature enzyme, Proteins Struct. Funct. Genet. 12, 339-344.
2. Barrett, A. J. & Kirschke, H. (1981) Cathepsin B, cathepsin H, and cathepsin L, Methods Enzymol. 80, 535-561.
3. Barrett, A. J., Kembhavi, A. A., Brown, M. A., Kirschke, H., Knight, C. G., Tamai, M. & Hanada, K. (1982) L-trans-Epoxysuccinyl-leucylamino(4-guanidino)butane (E64) and ist analogues as inhibitors of cysteine proteinases including cathepsin B, H, and L, Biochem. J. 201, 189-198.
4. Benelli, R., Adatia, R., Ensoli, B., Stetler Stevenson, W. G., Santi, L. & Albini, A. (1994) Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy. Oncol. Res. 6, 251-257.
5. Blum, H., Beier, H. & Goss, H. J. (1987) Improved silver staining of plant proteins, RNA, and DNA in polyacrylamide gels, Electrophoresis 8, 93-97.
6. Brömine, D., Bonneau, P. R., Lachance, P., Wiederanders, B., Kirschke, H., Peters, C., Thomas, D. Y., Storer, A. C. & Vernet, T. (1993) Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme, J. Biol. Chem. 268, 4832-4838.
7. Bromine, D. & McGrath, M. E. (1996) High level expression and crystallization of recombinant human cathepsin S. Protein Sci. 5, 789-791.
8. Carmona, E., Dufour, E., Plouffe, C., Takebe, S., Mason, P., Mort, J. S. & Menard, R. (1996) Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases, Biochemistry 35, 8149-8157.
9. Coulombe, R., Grochulski, P., Sivaraman, J., Menard, R., Mort, J. S. & Cygler, M. (1996) Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment, EMBO J. 15, 5492-5503.
10. Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A. C. & Mort, J. S. (1996) Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. Structure 4 (Lond.), 405-416.
11. Fox, T., de Miguel, E., Mort, J. S. & Storer, A. C. (1992) Potent slow-binding inhibition of cathepsin B by its propeptide, Biochemistry 31, 12571-12576.
12. Fusek, M., Mares, M., Vaguer, J., Voburka, Z. & Baudys, M. (1991) Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen, FEBS Lett 287, 160-162.
13. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
14. Mach, L., Mort, J. S. & Glössl, J. (1994a) Maturation of human procathepsin B, J. Biol. Chem. 269, 13030-13035.
15. Mach, L., Mort, J. S. & Glössl, J. (1994b) Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme, J. Biol. Chem. 269, 13036-13040.
16. Markaryan, A., Lee, J. D., Sirakova, T. D. & Kolattukudy, P. E. (1996) Specific inhibition of mature fungal serine proteinases and metalloproteinases by their propeptides, J. Bacteriol. 178, 2211-2215.
17. Mason, R. W., Gal, S. & Gottesman, M. M. (1987) The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L, Biochem. J. 248, 449-454.
18. McIntyre, G. E., Godbold, G. D. & Erickson, A. H. (1994) The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide, J. Biol. Chem. 269, 567-572.
19. McQueney, M. S., Amegadzie, B. Y. K. D. A., Hanning, C. R., McLaughlin, M. M., McNulty, D., Carr, S. A., Ijames, C., Kurdyla, J. & Jones, C. S. (1997) Autocatalytic activation of human cathepsin K. J. Biol. Chem. 272, 13955-13960.
20. Morrison, J. F. & Walsh, C. T. (1988) The behavior and significance of slow-binding enzyme inhibitors, Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301.
21. Rawlings, N. D. & Barrett, A. J. (1994) Families of cysteine peptidases, Methods Enzymol. 244, 461-486.
22. Taylor, M. A., Baker, K. C., Briggs, G. S., Connerton, I. F., Cummings, N. J., Pratt, K. A., Revell, D. F., Freedman, R. B. & Goodenough, P. W. (1995) Recombinant pro-regions from papain and papaya proteinase IV-are selective high affinity inhibitors of the mature papaya enzymes, Protein Eng. 8, 59-62.
23. Turk, D., Podobnik, M., Kuhelj, R., Dolinar, M. & Turk, V. (1996) Crystal structures of human procathepsin B at 3. 2 and 3. 3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide, FEBS Lett. 384, 211-214.
24. Völkel, H., Beltz, E., Klumpp, S. & Schultz, J. E. (1996) Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium, FEBS Lett. 378, 245-249.
25. Ward, W., Alvarado, L., Rawlings, N. D., Engel, J. C., Franklin, C. & McKerrow, J. H. (1997) A primitive enzyme for primitive cells: The protease required for excystation of Giandia, Cell 89, 437-444.
26. Wiederanders, B., Brömme, D., Kirschke, H., von Figura, K., Schmidt, B. & Peters, C. (1992) Phylogenetic conservation of cysteine proteinases, Cloning and expression of a cDNA coding for human cathepsin S. J. Biol. Chem. 267, 13708-13713.