Hypertonia in children: How and when to treat

Current Treatment Options in Neurology

Volumn 7, Issue 6, 2005, Pages 427-439

  Sanger, Terence D ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BACLOFEN; BENZODIAZEPINE DERIVATIVE; BOTULINUM TOXIN A; BOTULINUM TOXIN B; CARBIDOPA; CENTRAL STIMULANT AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONAZEPAM; DANTROLENE; DIAZEPAM; DOPAMINE RECEPTOR STIMULATING AGENT; ERYTHROMYCIN; LEVODOPA; LORAZEPAM; MONOAMINE OXIDASE INHIBITOR; PIMOZIDE; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR; TIZANIDINE; TRIHEXYPHENIDYL; VITAMIN;

ANHIDROSIS; ANTICHOLINERGIC EFFECT; ATAXIA; ATTENTION DEFICIT DISORDER; BRACE; BRADYCARDIA; BRAIN DEPTH STIMULATION; CEREBRAL PALSY; CHILD; COMMUNICATION AID; CONFUSION; CONSTIPATION; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DIET; DISEASE SEVERITY; DIZZINESS; DORSAL RHIZOTOMY; DOSE RESPONSE; DROWSINESS; DRUG CONTRAINDICATION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENTIATION; DYSPNEA; DYSTONIA; DYSURIA; EXERCISE; FATIGUE; GLAUCOMA; HEADACHE; HUMAN; HYPERBARIC OXYGEN; HYPOTENSION; IMPOTENCE; LIFESTYLE; LIVER FAILURE; LIVER TOXICITY; MANIPULATIVE MEDICINE; MELENA; MOTOR PERFORMANCE; MUSCLE HYPERTONIA; MUSCLE STIFFNESS; MUSCLE WEAKNESS; MYDRIASIS; NAUSEA; ORTHOTICS; OUTCOMES RESEARCH; PHYSIOTHERAPY; QT PROLONGATION; REVIEW; SALIVATION; SEDATION; SEIZURE; SPASTICITY; SPEECH THERAPY; SPORT; STANDING; STOMACH PAIN; SYNCOPE; TACHYCARDIA; TENOTOMY; THORAX PAIN; URINE RETENTION; VISUAL IMPAIRMENT; VITAMIN SUPPLEMENTATION; VOMITING; WHEELCHAIR; XEROSTOMIA;

EID: 28044465428     PISSN: 10928480     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11940-005-0043-x     Document Type: Review

References (107)

1. Sanger TD, Delgado MR, Gaebler-Spira D, et al.: Classification and definition of disorders causing hypertonia in childhood. Pediatrics 2003, 111:e89-e97.
2. Sanger TD: Pediatric movement disorders. Curr Opin Neurol 2003, 16:529-535.
3. Lance JW: What is spasticity? Lancet 1990, 335:606.
4. Lance JW, Burke D, Gillies JD: An electromyographic analysis of spasticity. Trans Am Neurol Assoc 1970, 95:272-274.
5. Sanger TD: Pathophysiology of pediatric movement disorders. J Child Neurol 2003, 18(Suppl 1):S9-S24.
6. Katz RT, Rymer WZ: Spastic hypertonia: mechanisms and measurement. Arch Phys Med Rehabil 1989, 70:144-155.
7. Katz RT, Rovai GP, Brait C, Rymer WZ: Objective quantification of spastic hypertonia: correlation with clinical findings. Arch Phys Med Rehabil 1992, 73:339-347.
8. Berger W, Quintern J, Dietz V: Pathophysiology of gait in children with cerebral palsy. Electroencephalogr Clin Neurophysiol 1982, 53:538-548.
9. Dietz V, Trippel M, Berger W: Reflex activity and muscle tone during elbow movements in patients with spastic paresis. Ann Neurol 1991, 30:767-779.
10. Dietz V: Human neuronal control of automatic functional movements: interaction between central programs and afferent input. Physiol Rev 1992, 72:33-69.
11. Jobin A, Levin MF: Regulation of stretch reflex threshold in elbow flexors in children with cerebral palsy: a new measure of spasticity. Dev Med Child Neurol 2000, 42:531-540.
12. Levin MF, Feldman AG: The role of stretch reflex threshold regulation in normal and impaired motor control. Brain Res 1994, 657:23-30.
13. Hiersemenzel LP, Curt A, Dietz V: From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology 2000, 54:1574-1582.
14. O'Dwyer NJ, Ada L: Reflex hyperexcitability and muscle contracture in relation to spastic hypertonia. Curr Opin Neurol 1996, 9:451-455.
15. O'Dwyer NJ, Ada L, Neilson PD: Spasticity and muscle contracture following stroke. Brain 1996, 119:1737-1749.
16. Lieber RL, Steinman S, Barash IA, Chambers H: Structural and functional changes in spastic skeletal muscle. Muscle Nerve 2004, 29:615-627.
17. Friden J, Lieber RL: Spastic muscle cells are shorter and stiffer than normal cells. Muscle Nerve 2003, 27:157-164.
18. Lieber RL, Friden J: Spasticity causes a fundamental rearrangement of muscle-joint interaction. Muscle Nerve 2002, 25:265-270.
19. Ibrahim IK, Berger W, Trippel M, Dietz V. Stretch-induced electromyographic activity and torque in spastic elbow muscles. Differential modulation of reflex activity in passive and active motor tasks. Brain 1993, 116:971-989.
20. Dietz V: Supraspinal pathways and the development of muscle-tone dysregulation. Dev Med Child Neurol 1999, 41:708-715.
21. Tate OJ, Damiano DL: Torque-EMG relationships in normal and spastic muscles. Electromyogr Clin Neurophysiol 2002, 42:347-357.
22. Crothers B, Paine R: The Natural History of Cerebral Palsy. In Classics in Developmental Medicine, vol 2. Edited by Mitchell R. Philadelphia: JB Lippincott; 1959.
23. Wagley PF: A study of spasticity and paralysis. Bull Johns Hopkins Hosp 1945, 77:218-273.
24. Young R: Spasticity: a review. Neurology 1994, 44(Suppl 9):S12-S20.
25. Sinkjaer T, Toft E, Larsen K, et al.: Non-reflex and reflex mediated ankle joint stiffness in multiple sclerosis patients with spasticity. Muscle Nerve 1993, 16:69-76.
26. Burke D: Spasticity as an adaptation to pyramidal tract injury. Adv Neurol 1988, 47:401-423.
27. Fahn S, Bressman SB, Marsden CD: Classification of dystonia. Adv Neurol 1998, 78:1-10.
28. Vitek JL, Giroux M: Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesia. Ann Neurol 2000, 47(Suppl 1):S131-S140.
29. Volpe JJ: Neurology of the Newborn, edn 4. Philadelphia: WB Saunders; 2000.
30. Pizoli CE, Jinnah HA, Billingsley ML, Hess EJ: Abnormal cerebellar signaling induces dystonia in mice. J Neurosci, 2002, 22:7825-7833.
31. LeDoux MS, Lorden JF: Abnormal spontaneous and harmaline-stimulated Purkinje cell activity in the awake genetically dystonic rat. Exp Brain Res 2002, 145:457-467.
32. LeDoux MS, Hurst DC, Lorden JF: Single-unit activity of cerebellar nuclear cells in the awake genetically dystonic rat. Neuroscience 1998, 86:533-545.
33. LeDoux MS, Lorden JF: Abnormal cerebellar output in the genetically dystonic rat. Adv Neurol 1998, 78:63-78.
34. LeDoux MS, Lorden JF, Meinzen-Derr J: Selective elimination of cerebellar output in the genetically dystonic rat. Brain Res 1995, 697:91-103.
35. LeDoux MS, Lorden JF, Ervin JM: Cerebellectomy eliminates the motor syndrome of the genetically dystonic rat. Exp Neurol 1993, 120:302-310.
36. Simonati A, Dalla Bernardina B, Colombari R, Rizzuto N: Ponto-cerebellar hypoplasia with dystonia: clinico-pathological findings in a sporadic case. Childs Nerv Syst 1997, 13:642-647.
37. Koepp M, Schelosky L, Cordes I, et al.: Dystonia in ataxia telangiectasia: report of a case with putaminal lesions and decreased striatal [123I]iodobenzamide binding. Mov Disord 1994, 9:455-459.
38. Gornall P, Hitchcock E, Kirkland IS: Stereotaxic neurosurgery in the management of cerebral palsy. Dev Med Child Neurol 1975, 17:279-286.
39. Fraioli B, Guidetti: Effects of stereotactic lesions of the dentate nucleus of the cerebellum in man. Appl Neurophysiol 1975, 38:81-90.
40. Mavroudakis N: Clinical neurophysiology of dystonia. Acta Neurol Belg 2005, 105:23-29.
41. Hirata Y, Schutz M, Altenmuller E, et al.: Sensory mapping of lip representation in brass musicians with embouchure dystonia. Neuroreport 2004, 15:815-818.
42. Byl NN: What can we learn from animal models of focal hand dystonia? Rev Neurol (Paris) 2003, 159:857-873.
43. McKenzie AL, Nagarajan SS, Roberts TP, et al.: Somatosensory representation of the digits and clinical performance in patients with focal hand dystonia. Am J Phys Med Rehabil 2003, 82:737-749.
44. Kaji R, Murase N, Urushihara R, Asanuma K: Sensory deficits in dystonia and their significance. Adv Neurol 2004, 94:11-17.
45. Quartarone A, Bagnato S, Rizzo V, et al.: Abnormal associative plasticity of the human motor cortex in writer's cramp. Brain 2003, 126:2586-2596.
46. Butterworth S, Francis S, Kelly E, et al.: Abnormal cortical sensory activation in dystonia: an fMRI study. Mov Disord 2003, 18:673-682.
47. Tinazzi M, Rosso T, Fiaschi A: Role of the somatosensory system in primary dystonia. Mov Disord 2003, 18:605-622.
48. Candia V, Wienbruch C, Elbert T, et al.: Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization. Proc Natl Acad Sci U S A 2003, 100:7942-7946.
49. Byl NN, Nagarajan SS, Merzenich MM, et al.: Correlation of clinical neuromusculoskeletal and central somatosensory performance: variability in controls and patients with severe and mild focal hand dystonia. Neural Plast 2002, 9:177-203.
50. Abbruzzese G, Berardelli A: Sensorimotor integration in movement disorders. Mov Disord 2003, 18:231-240.
51. Blake DT, Byl NN, Cheung S, et al.: Sensory representation abnormalities that parallel focal hand dystonia in a primate model. Somatosens Mot Res 2002, 19:347-357.
52. Sanger TD, Pascual-Leone A, Tarsy D, Schlaug G: Nonlinear sensory cortex response to simultaneous tactile stimuli in writer's cramp. Mov Disord 2002, 17: 105-111.
53. Bara-Jimenez W, Shelton P, Hallett M: Spatial discrimination is abnormal in focal hand dystonia. Neurology 2000, 55:1869-1873.
54. Sanger TD, Merzenich MM: Computational model of the role of sensory disorganization in focal task-specific dystonia. J Neurophysiol 2000, 84:2458-2464.
55. Dodd KJ, Taylor NF, Damiano DL: A systematic review of the effectiveness of strength-training programs for people with cerebral palsy. Arch Phys Med Rehabil 2002, 83:1157-1164.
56. Damiano DL, Quinlivan J, Owen BF, et al.: Spasticity versus strength in cerebral palsy: relationships among involuntary resistance, voluntary torque, and motor function. Eur J Neurol 2001, 12(Suppl 5):40-49.
57. Byl NN, Nagajaran S, McKenzie AL: Effect of sensory discrimination training on structure and function in patients with focal hand dystonia: a case series. Arch Phys Med Rehabil 2003, 84:1505-1514.
58. Zeuner KE, Bara-Jimenez W, Noguchi PS, et al.: Sensory training for patients with focal hand dystonia. Ann Neurol 2002, 51:593-598.
59. Zeuner KE, Hallett M: Sensory training as treatment for focal hand dystonia: a 1-year follow-up. Mov Disord 2003, 18:1044-1047.
60. Esquenazi A, Mayer NH: Instrumented assessment of muscle overactivity and spasticity with dynamic polyelectromyographic and motion analysis for treatment planning. Am J Phys Med Rehabil 2004, 83(Suppl):S19-S29.
61. Papadonikolakis AS, Vekris MD, Korompilias AV, et al.: Botulinum A toxin for treatment of lower limb spasticity in cerebral palsy: gait analysis in 49 patients. Acta Orthop Scand 2003, 74:749-755.
62. Kay RM, Rethlefsen SA, Fern-Buneo A, et al.: Botulinum toxin as an adjunct to serial casting treatment in children with cerebral palsy. J Bone Joint Surg Am 2004, 86-A:2377-2384.
63. Verplancke D, Snape S, Salisbury CF, et al.: A randomized controlled trial of botulinum toxin on lower limb spasticity following acute acquired severe brain injury. Clin Rehabil 2005, 19:117-125.
64. Bottos M, Benedetti MG, Salucci P, et al.: Botulinum toxin with and without casting in ambulant children with spastic diplegia: a clinical and functional assessment. Dev Med Child Neurol 2003, 45:758-762.
65. Hoon AH Jr, Freese PO, Reinhardt EM, et al.: Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. Pediatr Neurol 2001, 25:55-58.
66. Brunstrom JE, Bastian AJ, Wong M, Mink JW: Motor benefit from levodopa in spastic quadriplegic cerebral palsy. Ann Neurol 2000, 47:662-665.
67. Kim HS, Hwang JH, Jeong ST, et al.: Effect of muscle activity and botulinum toxin dilution volume on muscle paralysis. Dev Med Child Neurol 2003, 45:200-206.
68. Tilton AH: Management of spasticity in children with cerebral palsy. Semin Pediatr Neurol 2004, 11:58-65.
69. Koman LA, Paterson Smith B, Balkrishnan R. Spasticity associated with cerebral palsy in children: guidelines for the use of botulinum A toxin. Paediatr Drugs 2003, 5:11-23.
70. Schwerin A, Berweck S, Fietzek UM, Heinen F: Botulinum toxin B treatment in children with spastic movement disorders: a pilot study. Pediatr Neurol 2004, 31:109-113.
71. Chin TY, Graham HK: Botulinum toxin A in the management of upper limb spasticity in cerebral palsy. Hand Clin 2003, 19:591-600.
72. Graham HK, Aoki KR, Autti-Ramo I, et al.: Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. Gait Posture 2000, 11:67-79.
73. Kondo I, Hosokawa K, Iwata M, et al.: Effectiveness of selective muscle-release surgery for children with cerebral palsy: longitudinal and stratified analysis. Dev Med Child Neurol 2004, 46:540-547.
74. Awaad Y, Tayem H, Munoz S, et al.: Functional assessment following intrathecal baclofen therapy in children with spastic cerebral palsy. J Child Neurol 2003, 18:26-34.
75. Scheinberg A, O'Flaherty S, Chaseling R, Dexter M: Continuous intrathecal baclofen infusion for children with cerebral palsy: a pilot study. J Paediatr Child Health 2001, 37:283-288.
76. Albright AL, Barry MJ, Painter MJ, Shultz B: Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy. J Neurosurg 1998, 88:73-76.
77. Murphy NA, Irwin MC, Hoff C: Intrathecal baclofen therapy in children with cerebral palsy: efficacy and complications. Arch Phys Med Rehabil 2002, 83:1721-1725.
78. Gilmartin R, Bruce D, Storrs BB, et al.: Intrathecal baclofen for management of spastic cerebral palsy: multicenter trial. J Child Neurol 2000, 15:71-77.
79. Steinbok P, Daneshvar H, Evans D, Kestle JR: Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. Pediatr Neurosurg 1995, 22:255-264; discussion 265.
80. Morota N, Kameyama S, Masuda M, et al.: Functional posterior rhizotomy for severely disabled children with mixed type cerebral palsy. Acta Neurochir Suppl 2003, 87:99-102.
81. Engsberg JR, Ross SA, Wagner JM, Park TS: Changes in hip spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. Dev Med Child Neurol 2002, 44:220-226.
82. Kim DS, Choi JU, Yang KH, Park CI: Selective posterior rhizotomy in children with cerebral palsy: a 10-year experience. Childs Nerv Syst 2001, 17:556-562.
83. Boop FA, Woo R, Maria BL: Consensus statement on the surgical management of spasticity related to cerebral palsy. J Child Neurol 2001, 16:68-69.
84. Steinbok P: Outcomes after selective dorsal rhizotomy for spastic cerebral palsy. Childs Nerv Syst 2001, 17:1-18.
85. McLaughlin J, Bjornson K, Temkin N, et al.: Selective dorsal rhizotomy: meta-analysis of three randomized controlled trials. Dev Med Child Neurol 2002, 44:17-25.
86. Engsberg JR, Ross SA, Park TS: Changes in ankle spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. J Neurosurg 1999, 91:727-732.
87. Wright FV, Sheil EM, Drake JM, et al.: Evaluation of selective dorsal rhizotomy for the reduction of spasticity in cerebral palsy: a randomized controlled trial. Dev Med Child Neurol 1998, 40:239-247.
88. Steinbok P, Reiner AM, Beauchamp R, et al.: A randomized clinical trial to compare selective posterior rhizotomy plus physiotherapy with physiotherapy alone in children with spastic diplegic cerebral palsy. Dev Med Child Neurol, 1997, 39:178-184.
89. Steinbok P, Hicdonmez T, Sawatzky B, et al.: Spinal deformities after selective dorsal rhizotomy for spastic cerebral palsy. J Neurosurg 2005, 102(Suppl 4):363-373.
90. Subramanian N, Vaughan CL, Peter JC, Arens LJ: Gait before and 10 years after rhizotomy in children with cerebral palsy spasticity. J Neurosurg 1998, 88:1014-1019.
91. Willis JK, Morello A, Davie A, et al.: Forced use treatment of childhood hemiparesis. Pediatrics 2002, 110:94-96.
92. Taub E, Ramey SL, DeLuca S, Echols K: Efficacy of constraint-induced movement therapy for children with cerebral palsy with asymmetric motor impairment. Pediatrics 2004, 113:305-312.
93. Starr PA, Turner RS, Rau G, et al.: Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes. Neurosurg Focus 2004, 17:E4.
94. Gros C, Frerebeau P, Perez-Dominguez E, et al.: Long term results of stereotaxic surgery for infantile dystonia and dyskinesia. Neurochirurgia (Stuttg) 1976, 19:171-178.
95. Broggi G, Angelini L, Bono R, et al.: Long term results of stereotactic thalamotomy for cerebral palsy. Neurosurgery 1983, 12:195-202.
96. Vitek JL: Surgery for dystonia. Neurosurg Clin N Am 1998, 9:345-366.
97. Marks WJ: Deep brain stimulation for dystonia. Curr Treat Options Neurol 2005, 7:237-243.
98. Coubes P, Roubertie A, Vayssiere N, et al.: Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet 2000, 355:2220-2221.
99. Vidailhet M, Vercueil L, Houeto JL, et al.: Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med 2005, 352:459-467.
100. Cif L, El Fertit H, Vayssiere N, et al.: Treatment of dystonic syndromes by chronic electrical stimulation of the internal globus pallidus. J Neurosurg Sci 2003, 47:52-45.
101. Castelnau P, Cif L, Valente EM, et al.: Pallidal stimulation improves pantothenate kinase-associated neurodegeneration. Ann Neurol 2005, 57:738-741.
102. Greene P: Deep-brain stimulation for generalized dystonia. N Engl J Med 2005, 352:498-500.
103. Bronte-Stewart H: Surgical therapy for dystonia. Curr Neurol Neurosci Rep 2003, 3:296-305.
104. Krause M, Fogel W, Kloss M, et al.: Pallidal stimulation for dystonia. Neurosurgery 2004, 55:1361-1368; discussion 1368-1370.
105. Binder DK, Rau G, Starr PA: Hemorrhagic complications of microelectrode-guided deep brain stimulation. Stereotact Funct Neurosurg 2003, 80:28-31.
106. Vercueil L, Krack P, Pollak P: Results of deep brain stimulation for dystonia: a critical reappraisal. Mov Disord 2002, 17(Suppl 3):S89-S93.
107. Krauss JK, Loher TJ, Weigel R, et al.: Chronic stimulation of the globus pallidus internus for treatment of non-dYT1 generalized dystonia and choreoathetosis: 2-year follow up. J Neurosurg 2003, 98:785-792.