Physiology of hypokinetic and hyperkinetic movement disorders: Model for dyskinesia

Annals of Neurology

Volumn 47, Issue 4 SUPPL. 1, 2000, Pages

  Vitek, Jerrold L ^a   Giroux, Monique ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

BASAL GANGLION; CELL ACTIVITY; CELL SYNCHRONIZATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG INDUCED DISEASE; DYSKINESIA; DYSTONIA; GLOBUS PALLIDUS; HEMIBALLISM; HUMAN; HYPERKINESIA; HYPOKINESIA; MODEL; NERVE CELL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; THALAMOCORTICAL TRACT;

ANIMALS; DISEASE MODELS, ANIMAL; DYSKINESIA, DRUG-INDUCED; HAPLORHINI; HYPERKINESIS; HYPOKINESIA; PARKINSON DISEASE, SECONDARY;

EID: 0034105157     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (95)

1. Weiner W, Lang A. Movement disorders: a comprehensive survey. Mount Kisco, NY: Futura Publishing, 1989
2. Meyers R. Surgical interruption of the pallidofugal fibres: its effect on the syndrome paralysis agitans and technical considerations in its application. NY State J Med 1942;42:317-325
3. Meyers R. The modification of alternating tremors, rigidity and festination by surgery of the basal ganglia. Assoc Nerv Ment Disord 1942;20:602-665
4. Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990;250:1429-1432
5. Filion M, Tremblay L, Bédard PJ. Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys. Brain Res 1988;444:165-176
6. Miller WC, DeLong MR. Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of parkinsonism. In: Carpenter MB, Jayaraman A, eds. The basal ganglia II. New York: Plenum Press, 1987:415-427
7. Vitek JL, Ashe J, Kaneoke Y. Spontaneous neuronal activity in the motor thalamus: alteration in pattern and rate in parkinsonism [abstract]. Neuroscience 1994;20(Part 1):561
8. Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990; 249:1436-1438
9. 3H]muscimol binding in substantia nigra, entopeduncular nucleus, globus pallidus and thalamus after striatal lesions as demonstrated by quantitative receptor autoradiography. J Neurosci 1983;3:1189-1198
10. Pan HS, Penney JB, Young AB. Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxy-dopamine lesions of the medial forebrain bundle. J Neurochem 1985;45:1396-1404
11. Mitchell IJ. Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience 1989;32:213-226
12. Porrino LJ, Burns RS, Crane AM, et al. Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the primate. Life Sci 1987;40:1657-1664
13. Schwartzman RJ, Alexander GM, Ferraro TN, et al. Cerebral metabolism of parkinsonian primates 21 days after MPTP. Exp Neurol 1988;102:307-313
14. Crossman AR, Mitchell IJ, Sambrook MA. Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. Neuropharmacology 1985;24:587-591
15. Hutchison WD, Lozano AM, Davis K, et al. Differential neuronal activity in segments of globus pallidus in Parkinson's disease patients. Neuroreport 1994;5:1533-1537
16. Hutchison WD, Levy R, Dostrovsky JO, et al. Effects of apomorphine on globus pallidus neurons in Parkinsonian patients. Ann Neurol 1997;42:767-775
17. Sterio D, Beric A, Dogali M, et al. Neurophysiological properties of pallidal neurons in Parkinson's disease. Ann Neurol 1994;35: 586-591
18. Vitek JL, Kaneoke Y, Turner R, et al. Neuronal activity in the internal (GPi) and external (GPe) segments of the globus pallidus (GP) of parkinsonian patients is similar to that in the MPTP-treated primate model of parkinsonism. Soc Neurosci Abstr 1993; 19:1584 (Abstract)
19. Vitek JL, Bakay RAE, Hashimoto T, et al. Microelectrode-guided pallidotomy: technical approach and application for treatment of medically intractable Parkinson's disease. J Neurosurg 1998;88:1027-1043
20. Vitek JL, Chockkan V, Zhang J, et al. Neuronal activity in the basal ganglia in patients with generalized dystonia and hemiballismus. Ann Neurol 1999;46:22-35
21. Suarez J, Verhagen-Metman L, Reich S, et al. Pallidotomy for hemiballismus: efficacy and characteristics of neuronal activity. Ann Neurol 1997;42:807-811
22. Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, 'prefrontal' and 'limbic' functions. Prog Brain Res 1990;85: 119-146.
23. DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci 1990;13:281-285
24. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-375
25. Yoshida M, Rabin A, Anderson A. Monosynaptic inhibition of pallidal neurons by axon collaterals of caudatonigral fibers. Exp Brain Res 1972;15:333-347
26. Smith Y, Wichmann L, DeLong MR. The external pallidum and the subthalamic nucleus send convergent inputs onto single neurons in the internal pallidal segment in the monkey: anatomical organization and functional significance. In: Percheron G, McKenzie JS, Féger J, eds. The basal ganglia IV: new ideas and data on structure and function. New York: Plenum Press, 1994:51-61
27. Miller WC, DeLong MR. Parkinsonian symptomatology: an anatomical and physiological analysis. Ann NY Acad Sci 1988; 515:287-302
28. Filion M. Effects of interruption of the nigrostriatal pathway and of dopaminergic agents on the spontaneous activity of globus pallidus neurons in the awake monkey. Brain Res 1979; 178:425-441
29. Filion M, Tremblay L, Bédard P. Effects of dopamine agonists on the spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism. Brain Res 1991;547:152-161
30. Filion M, Tremblay L. Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism. Brain Res 1991;547:142-151
31. Wichmann T, Baron MS, DeLong MR. Local inactivation of the sensorimotor territories of the internal segment of the globus pallidus and the subthalamic nucleus alleviates parkinsonian motor signs in MPTP treated monkeys. In: Percheron G, McKenzie JS, Féger J, eds. The basal ganglia IV: new ideas and data on structure and function. New York: Plenum Press, 1994:357-364
32. Baron MS, Wichmann T, DeLong MR. Inactivation of the sensorimotor territory in the internal pallidum reverses parkinsonian signs in MPTP-treated monkeys. Soc Neurosci Abstr 1992;18:69 (Abstract)
33. Baron MS, Vitek JL, Bakay RAE, et al. Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol 1996;40:355-366
34. Lozano AM, Lang AE, Galvez-Jimenez N, et al. Effect of GPi pallidotomy on motor function in Parkinson's disease. Lancet 1995; 346:1383-1387
35. Lang A, Lozano A, Montgomery E, et al. Posteroventral medial pallidotomy in advanced Parkinson's disease. N Engl J Med 1997; 337:1036-1042
36. Dogali M, Sterio D, Fazzini E, et al. Effects of posteroventral pallidotomy on Parkinson's disease. Adv Neurol 1996;69:585-590
37. Limousin P, Krack P, Pollack P, et al. Electrical stimulation of the subthalamic: nucleus in advanced Parkinson's disease. N Engl J Med 1998;339:1105-1111
38. Kumar R, Lozano AM, Montgomery E, Lang AE. Pallidotomy and deep brain stimulation of the pallidum and subthalamic nucleus in advanced Parkinson's disease. Mov Disord 1998;13(Suppl 1): 73-82
39. Volkman J, Sturn V, Weiss P, et al. Bilateral high-frequency stimulation of the internal globus pallidus in advanced Parkinson's disease. Ann Neurol 1998;44:953-961
40. Gross C, Rougier A, Guehl D, et al. High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases. J Neurosurg 1997;87:491-498
41. Limousin P, Pollack P, Benazzous A, et al. Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 1995;345:91-95
42. Grafton S, Waters C, Sutton J, et al. Pallidotomy increases activity of motor association cortex in Parkinson's disease: a positron emission tomographic study. Ann Neurol 1995;37:776-783
43. 15O PET study. Brain 1997;120:1301-1313
44. Limousin P, Greene J, Pollack P, et al. Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease. Ann Neurol 1997;42:283-291
45. Davis K, Taub E, Houle S, et al. Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms. Nat Med 1997;3:671-674
46. Eidelberg D, Moeller J, Ishikawa T, et al. Regional metabolic correlates of surgical outcome following unilateral pallidotomy for Parkinson's disease. Ann Neurol 1996;39:450-459
47. Marsden CD, Obeso JA. The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease. Brain 1994;117:877-897
48. Narabayashi H. Tremor: its generation mechanism and treatment. In: Vinken PJ, Bruyn GW, Klawans HL, eds. Handbook of clinical neurology, Vol 5. Amsterdam: Elsevier Science, 1986:597-607
49. Vitek J. Stereotaxic surgery and deep brain stimulation for movement disorders. In: Watts RL, Koller WC, eds. Movement disorders: neurologic principles and practice. New York: McGraw-Hill, 1997:237-255
50. Vitek JL, Zhang J, Evatt ML, et al. GPi pallidotomy for dystonia: clinical outcome and neuronal activity. Adv Neurol 1998;78: 211-219
51. Wichmann T, DeLong M. Functional and pathophysiological models of the basal ganglia. Curr Opin Neurobiol 1996;6: 751-758
52. Vitek JL, Ashe J, DeLong MR, Alexander GE. Altered somatosensory response properties of neurons in the 'motor' thalamus of MPTP treated parkinsonian monkeys. Soc Neurosci Abstr 1990; 16:425 (Abstract)
53. Raz A, Feingold A, Vaadia E, et al. In phase neuronal oscillations in the basal ganglia of tremulous MPTP-treated vervet monkeys. Soc Neurosci Abstr 1997;23:466 (Abstract)
54. Nini A, Feingold A, Slovin H, Bergman H. Neurons in the globus pallidus do not show correlated activity in the normal monkey but phase-locked oscillations appear in the MPTP model of parkinsonism. J Neurophysiol 1995;74:1800-1805
55. Feingold A, Nini A, Raz A, et al. Neuronal oscillations and correlations in the basal ganglia of normal and MPTP-treated monkeys. Soc Neurosci Abstr 1996;22:414 (Abstract)
56. Taha J, Favre J, Baumann T, Burchiel K. Tremor control after pallidotomy in patients with Parkinson's disease: correlation with microrecording findings. J Neurosurg 1997;86:642-647
57. Taha JM, Favre J, Baumann TK, Burchiel KJ. Characteristics and somatotopic organization of kinesthetic cells in the globus pallidus in patients with Parkinson's disease. J Neurosurg 1996;85:1005-1012
58. Ryan LJ, Sanders DJ. Subthalamic nucleus lesion regularizes firing patterns in globus pallidus and substantia nigra pars reticulata neurons in rats. Brain Res 1993;626:327-331
59. Eidelberg D, Moeller JR, Ishikawa T, et al. Regional metabolic correlates of surgical outcome following unilateral pallidotomy for Parkinson's disease. Ann Neurol 1996;39:450-459
60. Kaneoke Y, Vitek JL, Ashe MR, et al. Altered somatosensory response properties of neurons in the cerebellar receiving area of the motor thalamus in MPTP treated parkinsonian monkeys. Soc Neurosci Abstr 1993;19:1585 (Abstract)
61. Hazrati L-N, Parent A. Projection from the external pallidum to the reticular thalamic nucleus in the squirrel monkey. Brain 1991;550:142-146
62. Ilinsky IA, Kultas-Ilinsky K. Reticular thalamic nucleus input to the nuclei of the monkey thalamus: light and electron-microscope study [abstract]. Neuroscience 1993;19(Part 2):14363
63. Yen CT, Jones EG. Intracellular staining of physiologically identified neurons and axons in the somatosensory thalamus of the cat. Brain Res 1983;280:148-154
64. Scheibel ME, Scheibel AB. The organization of the nucleus reticularios thalami: a golgi study. Brain Res 1966;1:43-62
65. Benazzouz A, Piallat B, Pollak P, Benabid A-L. Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data. Neurosci Lett 1995;189:77-80
66. Benabid AL, Pollak P, Limousin P, et al. Mechanism of action of STN stimulation in alleviation of Parkinson's disease symptoms. Soc Neurosci Abstr 1994;20(Part 1):2 (Abstract)
67. Hallanger AE, Levey AI, Lee HJ, et al. The origins of cholinergic and other subcortical afferents to the thalamus in the rat. J Comp Neurol 1987;262:105-124
68. Levey AI, Hallanger AE, Wainer BH. Cholinergic nucleus basalis neurons may influence the cortex via the thalamus. Neurosci Lett 1987;74:7-13
69. Steriade M, Pare D, Parent A, Smith Y. Projections of cholinergic and non-cholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey. Neuroscience 1988;25:47-67
70. McCormick DA, Prince DA. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986;319:402-405
71. McCormick DA, Pape H-C. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988;334:246-248
72. McCormick DA. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends Neurosci 1989;12:215-221
73. Jones EG. The thalamus. New York: Plenum Press, 1985
74. Pappa SM, Desimone R, Fiorani M, Oldfield EH. Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias. Ann Neurol 1999;46:732-738
75. Mitchell IJ, Boyce S, Sambrook MA, Crossman AR. A 2-deoxyglucose study of the effects of dopamine agonists on the parkinsonian primate brain. Implications for the neural mechanisms that mediate dopamine agonist-induced dyskinesia. Brain 1992;115: 809-824
76. Mitchell IJ, Luquin R, Boyce S, et al. Neural mechanisms of dystonia: evidence from a 2-deoxyglucose uptake study in a primate model of dopamine agonist-induced dystonia. Mov Disord 1990;5:49-54
77. Boyce S, Clarke CE, Luquin R. Induction of chorea and dystonia in parkinsonian primates. Mov Disord 1990;5:3-7
78. Clarke CE, Sambrook MA, Mitchell IJ, Cross AR. Levodopa-induced dyskinesia and response fluctuations in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). J Neurol Sci 1987;78:273-280
79. Hamada I, DeLong MR. Excitotoxic acid lesions of the primate subthalamic nucleus result in reduced pallidal neuronal activity during active holding. J Neurophysiol 1992;68:1859-1866
80. Merello M, Balej J, Delfino M, et al. Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease. Mov Disord 1999;14:45-49
81. Hayase N, Filion M, Richard H, Boraud T. Electrical stimulation of the subthalamic nucleus in fully Parkinsonian (MPTP) monkeys: effects on clinical signs and pallidal activity. In: Ohye O, Kimura M, McKenzie J, eds. The basal ganglia V. New York: Plenum Press, 1996:241-248
82. Llinas RR. Rebound excitation as the physiological basis for tremor: a biophysical study of the oscillatory properties of mammalian central neurones in vitro. In: Findley LJ, Capildeo R, eds. Movement disorders: tremor. London: Macmillan, 1984:165-182
83. Llinas RR. The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 1988;242:1654-1664
84. Jahnsen H, Llinas R. Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study. J Physiol 1984;349:205-226
85. Narabayashi H, Yokochi F, Nakajima Y. Levodopa-induced dyskinesia and thalamotomy. J Neurol Neurosurg Psychiatry 1984;47: 831-839
86. Dogali M, Fazzine E, Kolodny E, et al. Stereotactic ventral pallidotomy for Parkinson's disease. Neurology 1995;45:753-761
87. Yoshida M. The neuronal mechanism underlying parkinsonism and dyskinesia: differential roles of the putamen and caudate nucleus. Neurosci Res 1991;12:31-40
88. Hamada I. Direct and indirect pathways: why do pallidotomy and subthalamic stimulation work? In: Proceedings International Basal Ganglia Society, 6th Triennial Meeting, Brewster, MA, 1998
89. Singer W. A new job for the thalamus. Nature 1994;369:444-445
90. Riehle A, Grun S, Diesmann M, Aertsen A. Spike synchronization and rate modulation differentially involved in motor cortical function. Science 1997;278:1950-1953
91. Vitek JL, Zhang J, DeLong MR, et al. Neuronal activity in the pallidum in patients with medically intractable dystonia [abstract]. Mov Disord 1996;12(3):9
92. Vitek JL, Kaneoke Y, Hashimoto T, et al. Neuronal activity in the pallidum of a patient with hemiballismus. In: 120th Annual Meeting, American Neurological Association, Washington, DC, 1995, Abstracts 38-39
93. Hutchison W, Gross R, Lang A, Lozano A. Altered activity of globus pallidus (GP) neurons in dystonia. In: Society for Neuroscience 27th Annual Meeting, New Orleans, LA, 1997. Proceedings 23(1):471 (Abstract)
94. Blanchet PJ, Boucher R, Bédatd PJ. Excitotoxic lateral pallidotomy does not relieve L-dopa-induced dyskinesia in MPTP parkinsonian monkeys. Brain Res 1994;650:32-39
95. Boyce S, Clarke CE, Luquin R, et al. Induction of chorea and dystonia in parkinsonian primates. Mov Disord 1990;5:3-7