A simple and convenient procedure for lithiation and side-chain substitution of 2-alkyl-4-(methylthio)quinazolines and 2-alkyl-4- methoxyquinazolines

Synthesis

Volumn , Issue 17, 2005, Pages 2951-2961

  Smith, Keith ^a   El Hiti, Gamal A ^a,b   Hegazy, Amany S ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b Tanta University   (Egypt)

Author keywords

2 alkyl 4 (methylthio)quinazoline; 2 alkyl 4 methoxyquinazoline; Electrophiles; Lithiation; Side chain; Substitution

Indexed keywords

DERIVATIVES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

2-ALKYL-4-METHOXYQUINAZOLINE; ELECTROPHILES; LITHIATION; SIDE-CHAIN; SUBSTITUTION;

AMINES;

2 ETHYL 4 (METHYLTHIO)QUINAZOLINE; 2 ETHYL 4 METHOXYQUINAZOLINE; 2 METHYL 4 (METHYLTHIO)QUINAZOLINE; 4 (METHYLTHIO) 2 PROPYLQUINAZOLINE; 4 (METHYLTHIO)QUINAZOLINE; 4 ANISALDEHYDE; 4 METHOXY 2 METHYLQUINAZOLINE; 4 METHOXY 2 PROPYLQUINAZOLINE; ACETOPHENONE; BENZALDEHYDE; BENZOPHENONE; CYCLOHEXANONE; HEXAN 2 ONE; IODETHANE; QUINAZOLINE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; ELECTROPHILE; LITHIATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TEMPERATURE;

EID: 27944499777     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916036     Document Type: Article

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