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Volumn 5, Issue 2, 2005, Pages 22-35

Correlation between tau phosphorylation sites and tangle morphology in Alzheimer's disease

Author keywords

Alzheimer's disease; AT180; AT8; Extracellular ghost tangle; HT7; Intracellular tangle; Pretangle; Tau protein; Tau2; Tau5

Indexed keywords

MONOCLONAL ANTIBODY; SERINE; TAU 2 PROTEIN; TAU 5 PROTEIN; TAU PROTEIN; THREONINE; UNCLASSIFIED DRUG;

EID: 27944486753     PISSN: 13463500     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1479-8301.2005.00087.x     Document Type: Article
Times cited : (4)

References (56)
  • 1
    • 0036937699 scopus 로고    scopus 로고
    • Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    • Augustinack JC, Schneider A, Mandelkow EM, Hyman BT. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (Berl) 2002; 103: 26-35.
    • (2002) Acta Neuropathol (Berl) , vol.103 , pp. 26-35
    • Augustinack, J.C.1    Schneider, A.2    Mandelkow, E.M.3    Hyman, B.T.4
  • 2
  • 3
    • 0032894121 scopus 로고    scopus 로고
    • The biochemical pathways of neurofibrillary degeneration in aging and Alzheimer's disease
    • Delacourte A, David JP, Sergeant N et al. The biochemical pathways of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology 1999; 52: 1158-1165.
    • (1999) Neurology , vol.52 , pp. 1158-1165
    • Delacourte, A.1    David, J.P.2    Sergeant, N.3
  • 4
    • 0025360661 scopus 로고
    • Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type. Tau 64 and 69 are reliable markers of the neurofibrillary degeneration
    • Flament S, Delacourte A, Delaere P, Duyckaerts C, Hauw JJ. Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type. Tau 64 and 69 are reliable markers of the neurofibrillary degeneration. Acta Neuropathol (Berl) 1990; 80: 212-215.
    • (1990) Acta Neuropathol (Berl) , vol.80 , pp. 212-215
    • Flament, S.1    Delacourte, A.2    Delaere, P.3    Duyckaerts, C.4    Hauw, J.J.5
  • 5
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 1991; 82: 239-259.
    • (1991) Acta Neuropathol (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 6
    • 0036275991 scopus 로고    scopus 로고
    • Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles
    • Augustinack JC, Sanders JL, Tsai LH, Hyman BT. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. J Neuropathol Exp Neurol 2002; 61: 557-564.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 557-564
    • Augustinack, J.C.1    Sanders, J.L.2    Tsai, L.H.3    Hyman, B.T.4
  • 7
    • 0028362458 scopus 로고
    • A sequence of cytoskeletal changes related to the formation of neurofibrillary tangles and neuropil threads
    • Braak E, Braak H, Mandelkow EM. A sequence of cytoskeletal changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl) 1994; 87: 554-567.
    • (1994) Acta Neuropathol (Berl) , vol.87 , pp. 554-567
    • Braak, E.1    Braak, H.2    Mandelkow, E.M.3
  • 8
    • 0028918383 scopus 로고
    • Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease
    • Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol (Berl) 1995; 89: 291-295.
    • (1995) Acta Neuropathol (Berl) , vol.89 , pp. 291-295
    • Cras, P.1    Smith, M.A.2    Richey, P.L.3    Siedlak, S.L.4    Mulvihill, P.5    Perry, G.6
  • 9
    • 0025341754 scopus 로고
    • Tau protein: An update on structure and function
    • Lee G. Tau protein: an update on structure and function. Cell Motil Cytoskeleton 1990; 15: 199-203.
    • (1990) Cell Motil Cytoskeleton , vol.15 , pp. 199-203
    • Lee, G.1
  • 10
    • 0030067749 scopus 로고    scopus 로고
    • Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain
    • Singh TJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain. Mol Cell Biochem 1996; 154: 143-151.
    • (1996) Mol Cell Biochem , vol.154 , pp. 143-151
    • Singh, T.J.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 11
    • 0029789213 scopus 로고    scopus 로고
    • Phosphorylation of native and truncated isoforms of protein tau by the double-stranded DNA-dependent protein kinase (DNA-PK) shows that the primary phosphorylation sites are localized between amino acid residues 212-231 of the longest tau
    • Wu JM, Chen Y, Hsieh TC, Brandt R, Lee G. Phosphorylation of native and truncated isoforms of protein tau by the double-stranded DNA-dependent protein kinase (DNA-PK) shows that the primary phosphorylation sites are localized between amino acid residues 212-231 of the longest tau. Biochem Mol Biol Int 1996; 40: 21-31.
    • (1996) Biochem Mol Biol Int , vol.40 , pp. 21-31
    • Wu, J.M.1    Chen, Y.2    Hsieh, T.C.3    Brandt, R.4    Lee, G.5
  • 12
    • 0026030994 scopus 로고
    • Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease
    • Bancher C, Grundke-Iqbal I, Iqbal K, Fried VA, Smith HT, Wisniewski HM. Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease. Brain Res 1991; 539: 11-18.
    • (1991) Brain Res , vol.539 , pp. 11-18
    • Bancher, C.1    Grundke-Iqbal, I.2    Iqbal, K.3    Fried, V.A.4    Smith, H.T.5    Wisniewski, H.M.6
  • 13
    • 0033142961 scopus 로고    scopus 로고
    • Tau protein pathology in Alzheimer's disease and related disorders
    • Tolnay M, Probst A. Tau protein pathology in Alzheimer's disease and related disorders. Neuropathol Appl Neurobiol 1999; 25: 171-187.
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 171-187
    • Tolnay, M.1    Probst, A.2
  • 14
    • 0026458377 scopus 로고
    • Mapping of neurofibrillary degeneration in Alzheimer's disease: Evaluation of heterogeneity using the quantification of abnormal tau proteins
    • Vermersch P, Frigard B, Delacourte A. Mapping of neurofibrillary degeneration in Alzheimer's disease: evaluation of heterogeneity using the quantification of abnormal tau proteins. Acta Neuropathol (Berl) 1992; 85: 48-54.
    • (1992) Acta Neuropathol (Berl) , vol.85 , pp. 48-54
    • Vermersch, P.1    Frigard, B.2    Delacourte, A.3
  • 15
    • 0027984739 scopus 로고
    • Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
    • Goedert M, Jakes R, Crowther RA et al. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem J 1994; 301: 871-877.
    • (1994) Biochem J , vol.301 , pp. 871-877
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3
  • 16
    • 0028946744 scopus 로고
    • Monoclonal antibody AT8 recognizes tau protein phosphorylated at both serine 202 and threonine 205
    • Goedert M, Jakes R, Vanmechelen E. Monoclonal antibody AT8 recognizes tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 1995; 189: 167-169.
    • (1995) Neurosci Lett , vol.189 , pp. 167-169
    • Goedert, M.1    Jakes, R.2    Vanmechelen, E.3
  • 17
    • 0026512838 scopus 로고
    • Affinity purification of human tau proteins and the construction of a sensitive sandwich enzyme-linked immunosorbent assay for human tau detection
    • Mercken M, Vandermeeren M, Lubke U et al. Affinity purification of human tau proteins and the construction of a sensitive sandwich enzyme-linked immunosorbent assay for human tau detection. J Neurochem 1992; 58: 548-553.
    • (1992) J Neurochem , vol.58 , pp. 548-553
    • Mercken, M.1    Vandermeeren, M.2    Lubke, U.3
  • 18
    • 0023505501 scopus 로고
    • Phosphorylation determines two distinct species of tau in the central nervous system
    • Papasozomenos SC, Binder LI. Phosphorylation determines two distinct species of tau in the central nervous system. Cell Motil Cytoskeleton 1987; 8: 210-226.
    • (1987) Cell Motil Cytoskeleton , vol.8 , pp. 210-226
    • Papasozomenos, S.C.1    Binder, L.I.2
  • 19
    • 0024592795 scopus 로고
    • Tau protein immunoreactivity in dementia of the Alzheimertype. II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer's abnormal filaments
    • Papasozomenos SC. Tau protein immunoreactivity in dementia of the Alzheimertype. II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer's abnormal filaments. Lab Invest 1989; 60: 375-389.
    • (1989) Lab Invest , vol.60 , pp. 375-389
    • Papasozomenos, S.C.1
  • 20
    • 0029068246 scopus 로고
    • Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: Prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A
    • Papasozomenos SC, Su Y. Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A. J Neurochem 1995; 65: 396-406.
    • (1995) J Neurochem , vol.65 , pp. 396-406
    • Papasozomenos, S.C.1    Su, Y.2
  • 22
    • 0029817689 scopus 로고    scopus 로고
    • Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments
    • Kimura T, Ono T, Takamatsu J et al. Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia 1996; 7: 177-181.
    • (1996) Dementia , vol.7 , pp. 177-181
    • Kimura, T.1    Ono, T.2    Takamatsu, J.3
  • 23
    • 1542614533 scopus 로고    scopus 로고
    • Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease
    • Nakano H, Kobayashi K, Sugimori K et al. Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2004; 17: 122-131.
    • (2004) Dement Geriatr Cogn Disord , vol.17 , pp. 122-131
    • Nakano, H.1    Kobayashi, K.2    Sugimori, K.3
  • 24
    • 0027939401 scopus 로고
    • Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites
    • Su JH, Cummings BJ, Cotman CW. Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. Neuroreport 1994; 5: 2358-2362.
    • (1994) Neuroreport , vol.5 , pp. 2358-2362
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3
  • 25
    • 0027759674 scopus 로고
    • Synergistic control mechanism for abnormal site phosphorylation of Alzheimer's disease brain tau by kinase FA/GSK-3 alpha
    • Yang SD, Yu JS, Liu WK, Yen SH. Synergistic control mechanism for abnormal site phosphorylation of Alzheimer's disease brain tau by kinase FA/GSK-3 alpha. Biochem Biophys Res Commun 1993; 197: 400-406.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 400-406
    • Yang, S.D.1    Yu, J.S.2    Liu, W.K.3    Yen, S.H.4
  • 26
    • 0034920989 scopus 로고    scopus 로고
    • Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence
    • Uchihara T, Nakamura A, Yamazaki M, Mori O. Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathol (Berl) 2001; 101: 535-539.
    • (2001) Acta Neuropathol (Berl) , vol.101 , pp. 535-539
    • Uchihara, T.1    Nakamura, A.2    Yamazaki, M.3    Mori, O.4
  • 27
    • 0031961903 scopus 로고    scopus 로고
    • KP1 is a marker for extraneuronal neurofibrillary tangles and senile plaques in Alzheimer diseased brains
    • Kobayashi K, Muramori F, Aoki T et al. KP1 is a marker for extraneuronal neurofibrillary tangles and senile plaques in Alzheimer diseased brains. Dement Geriatr Cogn Disord 1998; 9: 13-19.
    • (1998) Dement Geriatr Cogn Disord , vol.9 , pp. 13-19
    • Kobayashi, K.1    Muramori, F.2    Aoki, T.3
  • 28
    • 0030636643 scopus 로고    scopus 로고
    • Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles
    • Schwab C, Steele JC, McGeer EG, McGeer PL. Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles. Acta Neuropathol (Berl) 1997; 93: 87-92.
    • (1997) Acta Neuropathol (Berl) , vol.93 , pp. 87-92
    • Schwab, C.1    Steele, J.C.2    McGeer, E.G.3    McGeer, P.L.4
  • 29
    • 0015168149 scopus 로고
    • Silver staining of Alzheimer's neurofibrillary changes by means of physical development
    • Gallyas F. Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 1971; 19: 1-8.
    • (1971) Acta Morphol Acad Sci Hung , vol.19 , pp. 1-8
    • Gallyas, F.1
  • 30
    • 0142087757 scopus 로고    scopus 로고
    • Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles
    • Lauckner J, Frey P, Geula C. Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles. Neurobiol Aging 2003; 24: 767-776.
    • (2003) Neurobiol Aging , vol.24 , pp. 767-776
    • Lauckner, J.1    Frey, P.2    Geula, C.3
  • 31
    • 0028345831 scopus 로고
    • Different rates of neuronal degeneration: An exquisite variation of the 'Cascade' hypothesis
    • Dani SU, Pittella JE, Hori A, Bergmann B, Stan AC, Walter GF. Different rates of neuronal degeneration: an exquisite variation of the 'Cascade' hypothesis. Dementia 1994; 5: 110-118.
    • (1994) Dementia , vol.5 , pp. 110-118
    • Dani, S.U.1    Pittella, J.E.2    Hori, A.3    Bergmann, B.4    Stan, A.C.5    Walter, G.F.6
  • 32
    • 0030943837 scopus 로고    scopus 로고
    • Progressive formation of neuritic plaques and neurofibrillary tangles is exponentially related to age and neuronal size. A morphometric study of three geographically distinct series of aging people
    • Dani SU, Pittella JE, Boehme A, Hori A, Schneider B. Progressive formation of neuritic plaques and neurofibrillary tangles is exponentially related to age and neuronal size. A morphometric study of three geographically distinct series of aging people. Dement Geriatr Cogn Disord 1997; 8: 217-227.
    • (1997) Dement Geriatr Cogn Disord , vol.8 , pp. 217-227
    • Dani, S.U.1    Pittella, J.E.2    Boehme, A.3    Hori, A.4    Schneider, B.5
  • 33
    • 0031691459 scopus 로고    scopus 로고
    • Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease
    • Vogt BA, Vogt LJ, Vrana KE et al. Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Exp Neurol 1998; 153: 8-22.
    • (1998) Exp Neurol , vol.153 , pp. 8-22
    • Vogt, B.A.1    Vogt, L.J.2    Vrana, K.E.3
  • 34
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992; 256: 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 35
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 2003; 24: 1063-1070.
    • (2003) Neurobiol Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    Laferla, F.M.5
  • 36
    • 0442323503 scopus 로고    scopus 로고
    • Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi
    • Park HJ, Seong YM, Choi JY, Kang S, Rhim H. Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi. Neurosci Lett 2004; 357: 63-67.
    • (2004) Neurosci Lett , vol.357 , pp. 63-67
    • Park, H.J.1    Seong, Y.M.2    Choi, J.Y.3    Kang, S.4    Rhim, H.5
  • 38
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-immunization in Alzheimer's disease
    • Ferrer I, Boada Rovira M, Sanchez Guerra ML, Rey MJ, Costa-Jussá F. Neuropathology and pathogenesis of encephalitis following amyloid-immunization in Alzheimer's disease. Brain Pathol 2004; 14: 11-20.
    • (2004) Brain Pathol , vol.14 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sanchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussá, F.5
  • 39
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-peptide: A case report
    • Nicoll JAR, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-peptide: a case report. Nat Med 2003; 9: 448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 40
    • 0033576794 scopus 로고    scopus 로고
    • Regional distribution of tau, β-amyloid and β-amyloid precursor protein in the Alzheimer's brain: A quantitative immunolabeling study
    • Schukla C, Bridges LR. Regional distribution of tau, β-amyloid and β-amyloid precursor protein in the Alzheimer's brain: a quantitative immunolabeling study. Neuroreport 1999; 10: 3785-3789.
    • (1999) Neuroreport , vol.10 , pp. 3785-3789
    • Schukla, C.1    Bridges, L.R.2
  • 41
    • 0033624303 scopus 로고    scopus 로고
    • Sequence of a beta-protein deposition in the human medial temporal lobe
    • Thal DR, Rub U, Schultz C et al. Sequence of A beta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 2000; 59: 733-748.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 733-748
    • Thal, D.R.1    Rub, U.2    Schultz, C.3
  • 42
    • 0037445602 scopus 로고    scopus 로고
    • Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease
    • Kobayashi K, Nakano H, Hayashi M et al. Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease. J Neurol Sci 2003; 208: 17-24.
    • (2003) J Neurol Sci , vol.208 , pp. 17-24
    • Kobayashi, K.1    Nakano, H.2    Hayashi, M.3
  • 43
    • 0036278099 scopus 로고    scopus 로고
    • Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease
    • Kobayashi K, Hayashi M, Nakano H et al. Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease. Neuropathol Appl Neurobiol 2002; 28: 238-251.
    • (2002) Neuropathol Appl Neurobiol , vol.28 , pp. 238-251
    • Kobayashi, K.1    Hayashi, M.2    Nakano, H.3
  • 44
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D et al. The Consortium to Establish a Registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 45
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985; 42: 1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 46
    • 0032712711 scopus 로고    scopus 로고
    • Characterization of microtubule-associated proteins in teleosts
    • Tomasiewicz HG, Wood JG. Characterization of microtubule-associated proteins in teleosts. Cell Motil Cytoskeleton 1999; 44: 155-167.
    • (1999) Cell Motil Cytoskeleton , vol.44 , pp. 155-167
    • Tomasiewicz, H.G.1    Wood, J.G.2
  • 47
    • 0025800101 scopus 로고
    • A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    • Iqbal K, Braak E, Braak H, Zaidi T, Grundke-Iqbal I. A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Neurobiol Aging 1991; 12: 357-361.
    • (1991) Neurobiol Aging , vol.12 , pp. 357-361
    • Iqbal, K.1    Braak, E.2    Braak, H.3    Zaidi, T.4    Grundke-Iqbal, I.5
  • 48
    • 0344838686 scopus 로고    scopus 로고
    • Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    • Bussière T, Gold G, Kövari E et al. Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience 2003; 117: 577-592.
    • (2003) Neuroscience , vol.117 , pp. 577-592
    • Bussière, T.1    Gold, G.2    Kövari, E.3
  • 49
    • 0026454256 scopus 로고
    • Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease
    • Hof PR, Bouras C, Buee L, Delacourte A, Perl DP, Morrison JH. Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease. Acta Neuropathol (Berl) 1992; 85: 23-30.
    • (1992) Acta Neuropathol (Berl) , vol.85 , pp. 23-30
    • Hof, P.R.1    Bouras, C.2    Buee, L.3    Delacourte, A.4    Perl, D.P.5    Morrison, J.H.6
  • 50
    • 0032528393 scopus 로고    scopus 로고
    • Regional quantitative analysis of tau-positive neurons in supranuclear palsy: Comparison with Alzheimer's disease
    • Li F, Iseki E, Odawara T, Kosaka K, Yagishita S, Amano N. Regional quantitative analysis of tau-positive neurons in supranuclear palsy: comparison with Alzheimer's disease. J Neurol Sci 1998; 159: 73-81.
    • (1998) J Neurol Sci , vol.159 , pp. 73-81
    • Li, F.1    Iseki, E.2    Odawara, T.3    Kosaka, K.4    Yagishita, S.5    Amano, N.6
  • 51
    • 0028864025 scopus 로고
    • Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease
    • Fukutani Y, Kobayashi K, Nakamura I, Watanabe K, Isaki K, Cairns NJ. Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease. Neurosci Lett 1995; 200: 57-60.
    • (1995) Neurosci Lett , vol.200 , pp. 57-60
    • Fukutani, Y.1    Kobayashi, K.2    Nakamura, I.3    Watanabe, K.4    Isaki, K.5    Cairns, N.J.6
  • 52
    • 0034929144 scopus 로고    scopus 로고
    • Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease
    • Garcia-Sierra F, Wischik CM, Harrington CR, Luna-Munoz J, Mena R. Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease. J Chem Neuroanat 2001; 22: 65-77.
    • (2001) J Chem Neuroanat , vol.22 , pp. 65-77
    • Garcia-Sierra, F.1    Wischik, C.M.2    Harrington, C.R.3    Luna-Munoz, J.4    Mena, R.5
  • 53
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997; 18: 351-357.
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 54
    • 0035139540 scopus 로고    scopus 로고
    • Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy
    • Hall GF, Lee VM, Lee G, Yao J. Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy. Am J Pathol 2001; 158: 235-246.
    • (2001) Am J Pathol , vol.158 , pp. 235-246
    • Hall, G.F.1    Lee, V.M.2    Lee, G.3    Yao, J.4
  • 55
    • 0033028074 scopus 로고    scopus 로고
    • Neurons may live for decades with neurofibrillary tangles
    • Morsch R, Simon W, Coleman PD. Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 1999; 58: 188-197.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 188-197
    • Morsch, R.1    Simon, W.2    Coleman, P.D.3
  • 56
    • 0032805805 scopus 로고    scopus 로고
    • On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam
    • Schwab C, Schulzer M, Steele JC, McGeer PL. On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam. Neurobiol Aging 1999; 20: 57-63.
    • (1999) Neurobiol Aging , vol.20 , pp. 57-63
    • Schwab, C.1    Schulzer, M.2    Steele, J.C.3    McGeer, P.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.