Progressive formation of neuritic plaques and neurofibrillary tangles is exponentially related to age and neuronal size

Dementia and Geriatric Cognitive Disorders

Volumn 8, Issue 4, 1997, Pages 217-227

  Dani, Sergio U ^a   Pittella, José Eymard H ^b   Boehme, Antje ^a   Hori, Akira ^a   Schneider, Berthold ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Aging; Alzheimer's disease; Neuritic plaques; Neurofibrillary tangles; Neuronal size; Protein metabolism

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAZIL; CONTROLLED STUDY; DEMENTIA; ENTORHINAL CORTEX; FEMALE; GERMANY; HUMAN; HUMAN TISSUE; INCIDENCE; JAPAN; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; NERVE DEGENERATION; NEURITE; NEUROFIBRILLARY TANGLE; ONSET AGE; PRIORITY JOURNAL;

ADULT; AGED; AGING; BRAIN; BRAZIL; CELL NUCLEUS; CELL SIZE; FEMALE; GERMANY; HUMANS; JAPAN; MALE; MIDDLE AGED; NERVE DEGENERATION; NEURITES; NEUROFIBRILLARY TANGLES; NEURONS; ORGAN SIZE;

EID: 0030943837     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000106634     Document Type: Article

References (38)

1. Dani SU: Larger neuronal size overwhelms maintenance capacity with aging. Med Hypotheses 1994;42:208-210.
2. Bekkers JM, Stevens CF: Two different ways evolution makes neurons larger. Prog Brain Res 1990;83:37-45.
3. Haug H: Brain sizes, surfaces, and neuronal sizes of the cortex cerebri: A stereological investigation of man and his variability and a comparison with some mammals (primates, whales, marsupials, insectivores, and one elephant). Am J Anat 1987;180:126-142.
4. Kosik KS: Alzheimer's disease: A cell biological perspective. Science 1992;256:780-783.
5. Dani SU: Spatial patterns of plaques and tangles in Alzheimer’s disease. Dementia 1994:5: 53.
6. Gibson PH: Form and distribution of senile plaques seen in silver-impregnated sections in the brains of intellectually normal elderly people and people with Alzheimer-type dementia. Neuropalhol Appl Neurobiol 1983;9:379-389.
7. Hardy JA, Higgins GA: Alzheimer’s disease: The amyloid cascade hypothesis. Science 1992; 256:184-185.
8. Lewis DA, Campbell MJ, Terry RD, Morrison JH: Laminar and regional distribution of neurofibrillary tangles and neuritic plaques in Alzheimer’s disease: A quantitative study of visual and auditory cortices. J Neurosci 1987;7:1799-1808.
9. Hyman BT, Marzloff K, Arriagada PV: The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol 1993;52:594-600.
10. Hyman BT, Weniger JJ, Tanzi RE: Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer’s disease: Expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Res Mol Brain Res 1993; 18: 253-258.
11. Schmidt ML, Murray JM, Trojaknowski JQ: Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex. A confocal laser scanning microscopy study. Mol Chem Neuropathol 1993; 18:299-312.
12. Défossez A, Delacourte A: Transformation of degenerating neurofibrils into amyloid substance in Alzheimer’s disease; Histochemical and immunohistochemical studies. J Neurol Sci 1987:81:1-10.
13. van Hoesen GW, Hyman BT, Damasio AR: Cell-specific pathology in neural systems of the temporal lobe in Alzheimer’s disease. Prog Brain Pathol 1986;70:321-335.
14. Hof PR, Cox K, Morrison JH: Quantitative analysis of a vulnerable subset of neurons in Alzheimer’s disease. I. Superior frontal and inferior temporal cortex. J Comp Neurol 1990; 301:44-54.
15. Hof PR, Morrison JH: Quantitative analysis of a vulnerable subset of neurons in Alzheimer’s disease. II. Primary and secondary visual cortex. J Comp Neurol 1990;301:55-64.
16. Hof PR, Bierer LM, Perl DP, Delacourte A, Buée L, Bouras C, Morrison JH: Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch Neurol 1992;49:943-953.
17. Rafalowska J, Barcikowska M, Wen GY, Wisniewski HM: Laminar distribution of neuritic plaques in normal aging. Alzheimer's disease and Down’s syndrome. Acta Neuropathol (Berl) 1988;77:21-25.
18. Rogers J, Morrison JH: Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer’s disease. J Neurosci 1985;5:2801-2808.
19. Hendrie HC, Osuntokun BO, Hall KS, Ogunniyi AO, Hui SL, Unverzagt FVV, Gurejc O, Rodenberg CA, Baiyewu O, Musick BS: Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry 1995; 152: 1485-1492.
20. Ogeng’o JA, Cohen DL. Sayi JG, Matuja WB, Chande HM, Kitinya JN, Kimani JK, Fried-land RP, Mori H, Kalaria RN: Cerebral amyloid β protein deposits and other Alzheimer lesions in non-demented elderly East Africans. Brain Pathol 1996;6:101-108. ’
21. Dani SU, Pittella JEH, Hori A, Bergmann B, Stan AC, Walter GF: Different rates of neuronal degeneration: An exquisite variation of the cascade hypothesis. Dementia 1994;5:110-118.
22. Dani SU, Weis S: Looking for histological correlates of dementia: The neurodcgcneration progression rate (NDPR). Clin Neuropathol 1994;5:240-241.
23. World Health Organization: The ICD-10 Classification of Mental and Behavioral Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva, World Health Organization, 1992.
24. Reusche E: Silver staining of senile plaques and neurofibrillary tangles in paraffin sections. A simple and effective method. Pathol Res Pract 1991;187:1045-1049.
25. Hinds JW, McNelly NA: Aging of the rat olfactory' bulb: Growth and atrophy of constituent layers and changes in size and number of mitral cells. J Comp Neurol 1977;72:345-367.
26. Lucassen PJ, Ravid R, Gonatas NK, Swaab DF: Activation of the human supraotic and paraventricular nucleus neurons with aging and in Alzheimer’s disease as judged from increasing size of the Golgi apparatus. Brain Res 1993;632:105-113.
27. Hyman BT, van Hoesen GW, Damasio AR, Barnes CL: Alzheimer’s disease: Cell specific pathology isolates the hippocampal formation. Science 1984:225:1168-1170.
28. Ball MJ, Hachinski V, Fox A, Kirshen AJ, Fisrnan M, Blume W, Kral VA, Fox H, Merskev H: A new definition of Alzheimer's dementia: A hippocampal dementia, Lancet 1985;i: 14-6.
29. Jamada M, Mehraein P: Verteilungsmuster der senilen Veränderungen im Gehirn. Die Beteiligung des limbischen Systems bei himatrophischen Prozessen des Seniums und bei Morbus Alzheimer. Arch Psychiatr Nervenkr 1968; 211:308-324.
30. Braak H, Braak E, Bohl J: Staging of Alzheimer-related cortical destruction. Eur Neurol 1993;33:403-408.
31. Abe H, Mehraein P, Weis S: Modified NOR silver impregnation technique for amyloid plaques and neurofibrillary tangles: Comparative assessment. Ncuropathol Appl Neurobiol 1994:20:478-486.
32. Pannese E: Neurocytology: Fine Structure of Neurons. Nerve Processes, and Neuroglial Cells. Stuttgart. Thieme. 1994. p 43.
33. Haug H: Macroscopic and microscopic morphometry of the human brain and cortex. A survey in the light of new results. Brain Pathol 1984;1:123-149.
34. Dekaban AS, Sadowsky D: Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights. Ann Neurol 1978:4:345-356.
35. Finch CE, Morgan DG: RNA and protein metabolism in the aging brain. Annu Rev Neurosci 1990;13:75-89.
36. Rattan SIS: Protein synthesis and the components of protein synthetic machinery during cellular aging. Mutat Res 1991:256:115-125.
37. Dani SU, Bergmann B, Walter GF, Pittella JEH, Hori A: A multivariate approach to the relationship between aging. RNA depletion and the incidence of plaques and tangles. Neuropathology (Kyoto) 1993; 13:243-249.
38. Haug H, Kuhl S, Mecke E, Sass NL, Wasner K: The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of human brain. J Hirnforsch 1984:25:353-374.