-
1
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
-
Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R (2000) Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 6(10):1167-1175
-
(2000)
Nat Med
, vol.6
, Issue.10
, pp. 1167-1175
-
-
Bielekova, B.1
Goodwin, B.2
Richert, N.3
Cortese, I.4
Kondo, T.5
Afshar, G.6
Gran, B.7
Eaton, J.8
Antel, J.9
Frank, J.A.10
McFarland, H.F.11
Martin, R.12
-
2
-
-
0030069797
-
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
-
Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, Fairchild PJ, Wraith DC, O'Garra A, Fathman CG, Steinman L (1996) Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343-345
-
(1996)
Nature
, vol.379
, pp. 343-345
-
-
Brocke, S.1
Gijbels, K.2
Allegretta, M.3
Ferber, I.4
Piercy, C.5
Blankenstein, T.6
Martin, R.7
Utz, U.8
Karin, N.9
Mitchell, D.10
Veromaa, T.11
Waisman, A.12
Gaur, A.13
Conlon, P.14
Ling, N.15
Fairchild, P.J.16
Wraith, D.C.17
O'Garra, A.18
Fathman, C.G.19
Steinman, L.20
more..
-
3
-
-
0022375427
-
Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
-
Fujinami RS, Olstone MBA (1985) Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230(4729):1043-1045
-
(1985)
Science
, vol.230
, Issue.4729
, pp. 1043-1045
-
-
Fujinami, R.S.1
Olstone, M.B.A.2
-
4
-
-
0031832479
-
A viral peptide with limited homology to a self-peptide can induce clinical signs of experimental autoimmune encephalomyelitis
-
Gautam AM, Liblau R, Chelvanayagam G, Steinman L, Boston T (1998) A viral peptide with limited homology to a self-peptide can induce clinical signs of experimental autoimmune encephalomyelitis. J Immunol 161:60-64
-
(1998)
J Immunol
, vol.161
, pp. 60-64
-
-
Gautam, A.M.1
Liblau, R.2
Chelvanayagam, G.3
Steinman, L.4
Boston, T.5
-
5
-
-
0347364679
-
Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis
-
Guggenmos J, Schubart AS, Ogg S, Andersson M, Olsson T, Mather IH, Linington C (2004) Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis. J Immunol 172(1):661-668
-
(2004)
J Immunol
, vol.172
, Issue.1
, pp. 661-668
-
-
Guggenmos, J.1
Schubart, A.S.2
Ogg, S.3
Andersson, M.4
Olsson, T.5
Mather, I.H.6
Linington, C.7
-
6
-
-
10744219605
-
Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis
-
Hughes LE, Smith PA, Bonell S, Natt RS, Wilson C, Rashid T, Amor S, Thompson EJ, Croker J, Ebringer A (2003) Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol 144(1-2):105-115
-
(2003)
J Neuroimmunol
, vol.144
, Issue.1-2
, pp. 105-115
-
-
Hughes, L.E.1
Smith, P.A.2
Bonell, S.3
Natt, R.S.4
Wilson, C.5
Rashid, T.6
Amor, S.7
Thompson, E.J.8
Croker, J.9
Ebringer, A.10
-
7
-
-
0033791462
-
Induction of a non-encephalitogenic Th2 autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo controlled, randomized phase II trial
-
Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L and the APL in Relapsing MS Study Group (2000) Induction of a non-encephalitogenic Th2 autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo controlled, randomized phase II trial. Nat Med 6(10):1176-1182
-
(2000)
Nat Med
, vol.6
, Issue.10
, pp. 1176-1182
-
-
Kappos, L.1
Comi, G.2
Panitch, H.3
Oger, J.4
Antel, J.5
Conlon, P.6
Steinman, L.7
-
8
-
-
15144342683
-
Short peptide-based tolerogens without self-antigenic or pathogenic activity reverse autoimmune disease
-
Karin N, Binah O, Grabie N, Mitchell D, Felzen B, Solomon M, Conlon P, Gaur A, Ling N, Steinman L (1998) Short peptide-based tolerogens without self-antigenic or pathogenic activity reverse autoimmune disease. J Immunol 160:5188-5194
-
(1998)
J Immunol
, vol.160
, pp. 5188-5194
-
-
Karin, N.1
Binah, O.2
Grabie, N.3
Mitchell, D.4
Felzen, B.5
Solomon, M.6
Conlon, P.7
Gaur, A.8
Ling, N.9
Steinman, L.10
-
9
-
-
0026664422
-
Spreading of T cell autoimmunity to cryptic determinants of an autoantigen
-
Lehmann P, Forsthuber T, Miller A, Sercarz EE (1992) Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155-157
-
(1992)
Nature
, vol.358
, pp. 155-157
-
-
Lehmann, P.1
Forsthuber, T.2
Miller, A.3
Sercarz, E.E.4
-
10
-
-
0030796646
-
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
-
Miller SD, Vanderblugt CL, Begolks WS, Pao W, Yauch RL, Neville KL, Katz-Levy Y, Carrizosa A, Kim BS (1997) Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med 3:1133-1136
-
(1997)
Nat Med
, vol.3
, pp. 1133-1136
-
-
Miller, S.D.1
Vanderblugt, C.L.2
Begolks, W.S.3
Pao, W.4
Yauch, R.L.5
Neville, K.L.6
Katz-Levy, Y.7
Carrizosa, A.8
Kim, B.S.9
-
11
-
-
0033103731
-
Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice
-
Mokhtarian F, Zhang Z, Shi Y, Gonzales E, Sobel RA (1999) Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice. J Neuroimmunol 95(1-2):43-54
-
(1999)
J Neuroimmunol
, vol.95
, Issue.1-2
, pp. 43-54
-
-
Mokhtarian, F.1
Zhang, Z.2
Shi, Y.3
Gonzales, E.4
Sobel, R.A.5
-
12
-
-
10744231057
-
Reverse genomics: Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis
-
Robinson, WH, Fontoura P, Lee BJ, Neuman de Vegvar HE, Tom J, Pedotti R, DiGennaro C, Mitchell DJ, Fong D, Ho PK, Ruiz P, Maverakis E, Stevens D, Bernard CCA, Olsson T, Martin R, Kuchroo VK, van Noort JM, Genain CP, Utz PJ, Garren H, Steinman L (2003) Reverse genomics: Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol 21:1033-1039
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1033-1039
-
-
Robinson, W.H.1
Fontoura, P.2
Lee, B.J.3
Neuman De Vegvar, H.E.4
Tom, J.5
Pedotti, R.6
Digennaro, C.7
Mitchell, D.J.8
Fong, D.9
Ho, P.K.10
Ruiz, P.11
Maverakis, E.12
Stevens, D.13
Bernard, C.C.A.14
Olsson, T.15
Martin, R.16
Kuchroo, V.K.17
Van Noort, J.M.18
Genain, C.P.19
Utz, P.J.20
Garren, H.21
Steinman, L.22
more..
-
13
-
-
0033583424
-
Microbial epitopes act as altered peptide ligands to prevent EAE
-
Ruiz PJ, Garren H, Hirschberg DL, Langer-Gould AM, Levite M, Karpuj MV, Southwood S, Sette A, Conlon P, Steinman L (1999) Microbial epitopes act as altered peptide ligands to prevent EAE. J Exp Med 189:1275-1284
-
(1999)
J Exp Med
, vol.189
, pp. 1275-1284
-
-
Ruiz, P.J.1
Garren, H.2
Hirschberg, D.L.3
Langer-Gould, A.M.4
Levite, M.5
Karpuj, M.V.6
Southwood, S.7
Sette, A.8
Conlon, P.9
Steinman, L.10
-
14
-
-
0023752774
-
Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein
-
Sakai K, Zamvil SS, Mitchell DJ, Lim M, Rothbard JB, Steinman L (1988) Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J Neuroimmunol 19:21-32
-
(1988)
J Neuroimmunol
, vol.19
, pp. 21-32
-
-
Sakai, K.1
Zamvil, S.S.2
Mitchell, D.J.3
Lim, M.4
Rothbard, J.B.5
Steinman, L.6
-
15
-
-
0032547858
-
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
-
Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW (1998) Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J Exp Med 188(8):1511-1520
-
(1998)
J Exp Med
, vol.188
, Issue.8
, pp. 1511-1520
-
-
Smith, K.J.1
Pyrdol, J.2
Gauthier, L.3
Wiley, D.C.4
Wucherpfennig, K.W.5
-
16
-
-
0035554898
-
Multiple sclerosis: A two stage disease
-
Steinman L (2001) Multiple sclerosis: a two stage disease. Nat Immunol 2:762-765
-
(2001)
Nat Immunol
, vol.2
, pp. 762-765
-
-
Steinman, L.1
-
17
-
-
3042847542
-
Immune therapy for autoimmune diseases
-
Steinman L (2004) Immune therapy for autoimmune diseases. Science 305:212-216
-
(2004)
Science
, vol.305
, pp. 212-216
-
-
Steinman, L.1
-
18
-
-
0030818169
-
Viral damage and the breakdown of self-tolerance
-
Steinman L, Conlon P (1997) Viral damage and the breakdown of self-tolerance. Nat Med 3:1085-1087
-
(1997)
Nat Med
, vol.3
, pp. 1085-1087
-
-
Steinman, L.1
Conlon, P.2
-
19
-
-
0037309220
-
Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis
-
Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ (2003) Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann Neurol 53(2):189-197
-
(2003)
Ann Neurol
, vol.53
, Issue.2
, pp. 189-197
-
-
Tejada-Simon, M.V.1
Zang, Y.C.2
Hong, J.3
Rivera, V.M.4
Zhang, J.Z.5
-
20
-
-
0032476612
-
In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis
-
Ufret-Vincenty R, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfennig KW, Brocke S (1998) In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J Exp Med 188:1725-1738
-
(1998)
J Exp Med
, vol.188
, pp. 1725-1738
-
-
Ufret-Vincenty, R.1
Quigley, L.2
Tresser, N.3
Pak, S.H.4
Gado, A.5
Hausmann, S.6
Wucherpfennig, K.W.7
Brocke, S.8
-
21
-
-
10244247768
-
Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)
-
Vergelli M, Hemmer B, Utz U, Vogt A, Kalbus M, Tranquill L, Conlon P, Ling N, Steinman L, McFarland H, Martin R (1996) Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur J Immunol 26:2624-2634
-
(1996)
Eur J Immunol
, vol.26
, pp. 2624-2634
-
-
Vergelli, M.1
Hemmer, B.2
Utz, U.3
Vogt, A.4
Kalbus, M.5
Tranquill, L.6
Conlon, P.7
Ling, N.8
Steinman, L.9
McFarland, H.10
Martin, R.11
-
22
-
-
0028864784
-
Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: The minimal B cell epitope and a model of its unique features
-
Warren KG, Catz I, Steinman L (1995) Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: The minimal B cell epitope and a model of its unique features. Proc Natl Acad Sci USA 92:11061-11065
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11061-11065
-
-
Warren, K.G.1
Catz, I.2
Steinman, L.3
-
23
-
-
0030856261
-
Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis
-
Warren KG, Catz I, Wucherpfennig KW (1997) Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis. J Neurol Sci 152(1):31-38
-
(1997)
J Neurol Sci
, vol.152
, Issue.1
, pp. 31-38
-
-
Warren, K.G.1
Catz, I.2
Wucherpfennig, K.W.3
-
24
-
-
0030961031
-
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2 restricted T cell clones from multiple sclerosis patients: Identity of key contact residues in the B-cell and T-cell epitopes
-
Wucherpfenig KW, Catz I, Hausmann S, Strominger JL, Steinman L, Warren KG (1997) Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2 restricted T cell clones from multiple sclerosis patients: Identity of key contact residues in the B-cell and T-cell epitopes. J Clin Invest 100:1114-1122
-
(1997)
J Clin Invest
, vol.100
, pp. 1114-1122
-
-
Wucherpfenig, K.W.1
Catz, I.2
Hausmann, S.3
Strominger, J.L.4
Steinman, L.5
Warren, K.G.6
-
25
-
-
0028926223
-
Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
-
Wucherpfennig KW, Strominger JL (1995) Molecular mimicry in T cell mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695-705
-
(1995)
Cell
, vol.80
, pp. 695-705
-
-
Wucherpfennig, K.W.1
Strominger, J.L.2
|