Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 3 39-3, 1999, Pages

  Mamotte, Cyril D S ^a   Sturm, Marian ^a   Foo, Jock I ^a   Van Bockxmeer, Frank M ^a   Taylor, Roger R ^a  

^a ROYAL PERTH HOSPITAL   (Australia)

Author keywords

Apolipoprotein E genotype; Fibroblasts; Hep G2 cells

Indexed keywords

APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; ATHEROSCLEROSIS; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CORONARY ARTERY DISEASE; FIBROBLAST; GENOTYPE; HOMOZYGOTE; HUMAN; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LIVER CELL; MALE; PRIORITY JOURNAL; RECEPTOR BINDING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032948510     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.3.e553     Document Type: Article

References (27)

1. Arnold, K. S., T. L. Innerarity, P. J. Blanch, and R. M. Krauss. Low density lipoproteins from normolipidaemic E2/2 homozygotes have reduced binding affinity to LDL receptors on normal human fibroblasts (Abstract). Circulation 88, Suppl. I: 321, 1993.
2. Bilheimer, D. W., S. Eisenberg, and R. T. Levy. The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. Biochim. Biophys. Acta 260: 212-221, 1972.
3. Boerwinkle, E., S. Brown, A. R. Sharrett, G. Heiss, and W. Patsch. Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations. Am. J. Hum. Genet. 54: 341-360, 1994.
4. Boerwinkle, E., and G. Utermann. Simultaneous effects of the apolipoprotein E polymorphism on apolipoproteiri E, apolipoprotein B, and cholesterol metabolism. Am. J. Hum. Genet. 42: 104-112, 1988.
5. Bohnet, K., T. Pillot, S. Visvikis, N. Sabolovic, and G. Siest. Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. J. Lipid Res. 37: 1316-1324, 1996.
6. Chappell, D. A., G. L. Fry, M. A. Waknitz, and J. J. Berns. Ligand size as a determinant for catabolism by the low density lipoprotein (LDL) receptor pathway: a lattice model for LDL binding. J. Biol. Chem. 266: 19296-19302, 1991.
7. Chappell, D. A., G. L. Fry, M. A. Waknitz, L. E. Muhonen, and M. W. Pladet. Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipoproteins in vitro. J. Biol. Chem. 268: 25487-25493, 1993.
8. Demant, T., D. Bedford, C. J. Packard, and J. Shepherd. Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J. Clin. Invest. 88: 1490-1501, 1991.
9. Edelstein, C., and A. M. Scanu. Precautionary measures for collecting blood destined for lipoprotein isolation. Methods Enzymol. 128: 151-155, 1986.
10. Gianturco, S. H., C. J. Packard, J. Shepherd, L. C. Smith, A. L. Catapano, H. D. Sybers, and A. A. Gotto, Jr. Abnormal suppression of 3-hydroxy-3-methyl-CoA reductase activity in cultured human fibroblasts by hypertriglyceridaemic very low density lipoprotein subclasses. Lipids 15: 456-463, 1980.
11. Goldstein, J. L., S. K. Basu, and M. S. Brown. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98: 241-260, 1983.
12. Gregg, R. E., and H. B. Brewer, Jr. The role of apolipoprotein E and lipoprotein receptors in modulating the in vivo metabolism of apolipoprotein B-containing lipoproteins in humans. Clin. Chem. 34, Suppl.: B28-B32, 1988.
13. Gregg, R. E., L. A. Zech, E. J. Schaefer, D. Stark, D. Wilson, and H. B. Brewer, Jr. Abnormal in vivo metabolism of apolipoprotein E4 in humans. J. Clin. Invest. 78: 815-821, 1986.
14. Hixson, J. E., and D. T. Vernier. Restriction isotyping of human apolipoprotein E by E gene amplification and cleavage with Hhal. J. Lipid Res. 31: 545-548, 1990.
15. Hoeg, J. M., S. J. Demosky, K. J. Lackner, J. C. Osborne, C. Oliver, and H. B. Brewer. The expressed hepatic receptor for low-density lipoprotein differs from the fibroblast low-density lipoprotein receptor. Biochim. Biophys. Acta 876: 13-21, 1986.
16. Holmquist, L., and K. Carlson. Selective extraction of human serum very low density apolipoproteins with organic solvents. Biochim. Biophys. Acta 493: 400-409, 1977.
17. Ji, Z. S., S. Fazio, and W. Mahley. Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinaemia. J. Biol. Chem. 269: 13421-13428, 1994.
18. Kesaniemi, Y. A., C. Ehnholm, and T. A. Miettinen. Intestinal cholesterol absorption efficiency in man is related to apolipoprotein E phenotype. J. Clin. Invest. 80: 578-581, 1987.
19. Khouw, A. S., S. Parthasarathy, and J. L. Witztum. Radioiodination of low density lipoprotein initiates lipid peroxidation: protection by use of antioxidants. J. Lipid Res. 34: 1483-1496, 1993.
20. Mamotte, C. D. S., M. Sturm, J. I. Foo, F. M. van Bockxmeer, and R. R. Taylor. Familial defective apolipoprotein B-100: effect of simvastatin on LDL-receptor binding. Atherosclerosis 155: 103-110, 1996.
21. Markwell, M. A., S. M. Haas, L. L. Bieber, and N. E. Tolbert. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87: 206-210, 1978.
22. Marz, W., M. W. Baumstark, H. Scharnagl, V. Ruzicka, S. Buxbaum, J. Herwig, T. Pohl, A. Russ, L. Schaaf, A. Berg, H. J. Bohles, K. H. Usadel, and W. Gro. Accumulation of "small dense" low density lipoproteins (LDL) in a homozygous patient with familial defective apolipoprotein B-100 results from heterogenous interaction of LDL subfractions with the LDL receptor. J. Clin. Invest. 92: 2922-2933, 1993.
23. McKeone, B. J., J. R. Patsch, and H. J. Pownall. Plasma triglycerides determine low density lipoprotein composition, physical properties, and cell-specific binding in cultured cells. J. Clin. Invest. 91: 1926-1933, 1993.
24. Semenkovich, C. F., and R. E. Ostlund. Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line HepG2. Biochemistry 26: 4987-4992, 1987.
25. Weintraub, M. S., S. Eisenberg, and J. L. Breslow. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J. Clin. Invest. 80: 1571-1577, 1987.
26. Weisgraber, K. H. Apolipoprotein E: structure-function relationships. Adv. Protein Chem. 45: 249-302, 1994.
27. Wilson, P. W. F., E. J. Schaefer, M. G. Larson, and J. M. Ordovas. Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler. Thromb. Vasc. Biol. 16: 1250-1255, 1996.