Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion

Blood

Volumn 97, Issue 12, 2001, Pages 3798-3805

  Watanabe, Yasuyuki ^a   Ito, Masaaki ^a   Kataoka, Yoshiyuki ^a   Wada, Hideo ^a   Koyama, Mutsumi ^a   Feng, Jianhua ^a   Shiku, Hiroshi ^a   Nishikawa, Masakatsu ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADENOSINE TRIPHOSPHATE; FURA 2; IONOMYCIN; MYOSIN PHOSPHATASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATASE; PHOSPHOPROTEIN; PROTEIN KINASE C; RHO KINASE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE RELEASE REACTION;

EID: 0035877985     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.12.3798     Document Type: Article

References (49)

1. Siess W. Molecular mechanisms of platelet activation. Physiol Rev. 1989;69:58-178.
2. Kroll MH, Sullivan R. Mechanisms of platelet activation. In: Loscalzo J, Schafer AI, eds. Thrombosis and Hemorrhage. Baltimore, MD: Williams & Wilkins; 1998:261-291.
3. Daniel JL, Molish IR, Rigmaiden M, Stewart G. Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response. J Biol Chem. 1984;259:9826-9831.
4. Bauer M, Retzer M, Wilde JI, et al. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood. 1999;94:1665-1672.
5. 2+-calmodulin-dependent phosphorylation and platelet secretion. Nature. 1980;287:863-865.
6. Hallam TJ, Daniel JL, Kendrick-Jones J, Rink TJ. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. Biochem J. 1985;232:373-377.
7. 2+-independent actions of phorbol ester and GTPγS. Cell Regul. 1990;1:1027-1041.
8. Sellers JR. Regulation of cytoplasmic and smooth muscle myosin. Curr Opin Cell. Biol. 1991;3:98-104.
9. Amano M, Ito M, Kimura K, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem. 1996;271:20246-20249.
10. Hartshorne DJ, Ito M, Erdödi F. Myosin light chain phosphatase: subunit composition, interactions, and regulation. J Muscle Res Cell Motil. 1998;19:325-341.
11. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522:177-185.
12. Shimizu H, Ito M, Miyahara M, et al. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase. J Biol Chem. 1994;269:30407-30411.
13. Alessi D, MacDougall LK, Sola MM, Ikebe M, Cohen P. The control of protein phosphatase-1 by targeting subunits: the major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1. Eur J Biochem. 1992;210:1023-1035.
14. Shirazi A, lizuka K, Fadden P, et al. Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. J Biol Chem. 1994;269:31598-31606.
15. Gong MC, Fuglsang A, Alessi D, et al. Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium. J Biol Chem. 1992;267:21492-21498.
16. 2+ sensitization of rabbit smooth muscle. J Physiol. 1997;500:95-109.
17. Ichikawa K, Ito M, Hartshorne DJ. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity. J Biol Chem. 1996;271:4733-4740.
18. Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-Kinase). Science. 1996;273:245-248.
19. Eto M, Ohmori T, Suzuki M, Furuya K, Morita F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C: isolation from porcine aorta media and characterization. J Biochem. 1995;118:1104-1107.
20. Eto M, Senba S, Morita F, Yazawa M. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle. FEBS Lett. 1997;410:356-360.
21. Senba S, Eto M, Yazawa M. Identification of trimeric myosin phosphatase (PP1M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle. J Biochem. 1999;125:354-362.
22. Li L, Eto M, Lee MR, Morita F, Yazawa M, Kitazawa T. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle. J Physiol. 1998;508:871-881.
23. 2+ sensitization in Triton X-100-demembranated rabbit arterial smooth muscle. J Physiol. 1999;520:139-152.
24. Narumiya S. The small GTPase Rho: cellular functions and signal transduction. J Biochem. 1996;120:215-228.
25. Feng J, Ito M, Ichikawa K, et al. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem. 1999;274:37385-37390.
26. Nakai K, Suzuki Y, Kihira H, et al. Regulation of myosin phosphatase through phosphorylation of the myosin binding subunit in platelet activation. Blood. 1997;90:3936-3942.
27. Suzuki Y, Yamamoto M, Wada H, et al. Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rhokinase. Blood. 1999;93:3408-3417.
28. Kitazawa T, Eto M, Woodsome TP, Brautigan DL. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem. 2000;275:9897-9900.
29. Toyoda H, Nakai K, Omay SB, et al. Differential association of protein Ser/Thr phosphatase type 1 and 2A with the cytoskeleton upon platelet activation. Thromb Haemost. 1996;76:1053-1062.
30. Koyama M, Ito M, Feng J, et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett. 2000;475:197-200.
31. Sakurada K, Seto M, Sasaki Y. Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture. Am J Physiol. 1998;274:C1563-C1572.
32. Nishikawa M, Shirakawa S, Adelstein RS. Phosphorylation of smooth muscle myosin light chain kinase by protein kinase C. J Biol Chem. 1985;260:8978-8983.
33. Nishikawa M, Toyoda H, Saito M, et al. Calyculin A and okadaic acid inhibit human platelet aggregation by blocking protein phosphatases types 1 and 2A. Cell Signal. 1994;6:59-71.
34. 3-induced up-regulation of calcineurin during leukemic HL-60 cell differentiation. Blood. 1996;87:2947-2955.
35. 3-induced monocytic differentiation of leukemic HL-60 cells. FEBS Lett. 1995;375:299-303.
36. Nishikawa M, Komada F, Morita K, Deguchi K, Shirakawa S. Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase. Cell Signal. 1992;4:453-463.
37. 2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium. 1985;6:145-157.
38. Toullec D, Pianetti P, Coste H, et al. The bisindolylmaleimide GF109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991;266:15771-15781.
39. Sherry JM, Gorecka A, Aksoy MO, Dabrowska R, Hartshorne DJ. Roles of calcium and phosphorylation in the regulation of the activity of gizzard myosin. Biochemistry. 1978;17:4411-4418.
40. 2+ and activate phospholipase A without activating phospholipase C. Biochem Biophys Res Commun. 1984;123:393-397.
41. Rink TJ, Sanchez A, Hallam TJ. Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets. Nature. 1983;305:317-319.
42. Naka M, Nishikawa M, Adelstein RS, Hidaka H. Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains. Nature. 1983;306:490-492.
43. Nishikawa M, Hidaka H, Adelstein RS. Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase: the effect on actin-activated MgAT-Pase activity. J Biol Chem. 1983;258:14069-14072.
44. Uehata M, Ishizaki T, Satoh H, et al. Calcium sensitization of smooth muscle mediated by a Rhoassociated protein kinase in hypertension. Nature. 1997;389:990-994.
45. Hamaguchi T, Ito M, Feng J, et al. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. Biochem Biophys Res Commun. 2000;274:825-830.
46. q family. J Biol Chem. 1991;266:9309-9313.
47. 2 and thrombin receptors in human platelets. Proc Natl Acad Sci U S A. 1994;91:504-508.
48. 13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol. 1999;144:745-754.
49. i2 in phospholipid vesicles. Mol Pharmacol. 1994;46:808-816.