Signal transduction in smooth muscle selected contribution: Insulin utilizes NO/cGMP pathway to activate myosin phosphatase via Rho inhibition in vascular smooth muscle

Journal of Applied Physiology

Volumn 91, Issue 3, 2001, Pages 1475-1482

  Sandu, Oana A ^a   Ito, Masaaki ^b   Begum, Najma ^a,c  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b MIE UNIVERSITY   (Japan)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Hypertension; Myosin bound phosphatase activation; Myosin bound phosphatase site specific phosphorylation; Rho kinase; Vasodilation

Indexed keywords

8 BROMO CYCLIC GMP; CYCLIC GMP; CYCLIC GMP DERIVATIVE; INSULIN; MYOSIN PHOSPHATASE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATASE; PROTEIN SUBUNIT; RHO KINASE; THROMBIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; MYOSIN; MYOSIN LIGHT CHAIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE; THREONINE;

ANIMAL TISSUE; ARTICLE; CLINICAL PATHWAY; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HYPERTENSION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; VASODILATATION; WISTAR KYOTO RAT;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CYCLIC GMP; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN PHOSPHATASE; MYOSINS; NITRIC OXIDE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, INBRED WKY; SIGNAL TRANSDUCTION; THREONINE; VASODILATION;

EID: 0034875525     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.91.3.1475     Document Type: Article

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