Epistasis in Quantitative Trait Locus Linkage Analysis: Interaction or Main Effect?

Behavior Genetics

Volumn 34, Issue 2, 2004, Pages 143-152

  Purcell, Shaun ^a   Sham, Pak C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Epistasis; Linkage analysis; Quantitative trait loci (QTL); Sibling pairs

Indexed keywords

ARTICLE; BEHAVIOR GENETICS; BIOMETRY; CALCULATION; EPISTASIS; LINKAGE ANALYSIS; MODEL; QUANTITATIVE TRAIT LOCUS; SIBLING;

ALLELES; CHROMOSOME MAPPING; EPISTASIS, GENETIC; GENE FREQUENCY; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL; QUANTITATIVE TRAIT LOCI;

EID: 1442308248     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BEGE.0000013728.96408.f9     Document Type: Article

References (24)

1. Cockerham, C. C. (1954). An extension of the concept of partitioning hereditary variance for analysis of covariance among relatives when epistasis is present. Genetics 39:859-882.
2. Culverhouse, R., Suarez, B. K., Lin, J., and Reich, T. (2002). A perspective on epistasis: Limits of models displaying no main effect. Am. J. Hum. Genet. 70:461-471.
3. Eaves, L. J. (1994). Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci. Heredity 72:175-192.
4. Frankel, W. N., and Schork, N. J. (1996). Who's afraid of epistasis? Nat. Genet. 14:371-373.
5. Gurganus, M. C., Nuzhdin, S. V., Leips, J. W., and Mackay, T. F. C. (1999). High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster. Genetics 152:1585-1604.
6. Haseman, J. K., and Elston, R. C. (1972). The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 2:3-19.
7. Jansen, R. C. (1996). Complex plant traits: Time for polygenic analysis. Trends Plant Sci. 1:89-94.
8. Kempthorne, O. (1957). An introduction to genetic statistics. New York: Wiley.
9. Leips, J., and Mackay, T. F. C. (2000). Quantitative trait loci for lifespan in Drosophila melanogaster: Interactions with genetic background and larval density. Genetics 155:1773-1788.
10. Li, W., and Reich, J. (2000). A complete enumeration and classification of two-locus disease models. Hum. Hered. 50:334-349.
11. Mackay, T. F. C. (2001). Quantitative trait loci in Drosophila. Nat. Rev. Genet. 2:11-20.
12. Mather, K. (1974). Non-allelic interactions in continuous variation of randomly breeding populations. Heredity 32:414-419.
13. Mitchell, B. D., Ghosh, S., Schneider, J. L., Birznieks, G., and Blangero, J. (1997). Power of variance component linkage analysis to detect epistasis. Gen. Epidemiol. 14:1017-1022.
14. Neuman, R. J., and Rice, J. P. (1992). Two-locus models of diseases. Genet. Epidemiol. 9:347-365.
15. Risch, N. (1990). Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46:222-228.
16. Risch, N., Spiker, D., Lotspeich, L., Nouri, N., Hinds, D., Hallmayer, J., Kalaydjieva, L. et al. (1999). A genomic screen of autism: Evidence for a multilocus etiology. Am. J. Hum. Genet. 65:493-507.
17. Schork, N. J. (1993). Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modelling considerations. Am. J. Hum. Genet. 53:1306-1319.
18. Sham, P. C. (1998). Statistics in human genetics. London: Arnold.
19. Sham, P. C., Cherny, S. S., Purcell, S., and Hewitt, J. K. (2000). Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am. J. Hum. Genet. 66:1616-1630.
20. Tiwari, H. K., and Elston, R. C. (1997a). Deriving components of genetic variance for multilocus models. Genet. Epidemiol. 14:1131-1136.
21. Tiwari, H. K., and Elston, R. C. (1997b). Linkage of multilocus components of variance to polymorphic markers. Ann. Hum. Genet. 61:253-261.
22. Tiwari, H. K., and Elston, R. C. (1998). Restrictions on components of variance for epistatic models. Theor. Popul. Biol. 54:161-174.
23. van Wezel, T., Stassen, A. P. M., Moen, C. J. A., Hart, A. A. M., van der Valk, M. A., and Demant, P. (1996). Gene interaction and single gene effects in colon tumour suspeptibility in mice. Nat. Genet. 14:468-470.
24. Weber, K., Eisman, R., Morey, L., Patty, A., Sparks, J., Tausek, M., and Zeng, Z.-B. (1999). An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster. Genetics 153:773-786.