Induction of δ opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons

Molecular Pharmacology

Volumn 68, Issue 6, 2005, Pages 1688-1698

  Walwyn, Wendy ^a   Maidment, Nigel T ^a   Sanders, Matthew ^b   Evans, Christopher J ^a   Kieffer, Brigitte L ^c   Hales, Tim G ^d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d GEORGE WASHINGTON UNIVERSITY   (United States)

^e GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BACLOFEN; CALCIUM CHANNEL; DELTA OPIATE RECEPTOR; DELTORPHIN; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MEMBRANE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL SURFACE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE DELETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSORY NERVE; SPINAL GANGLION; UPREGULATION;

ANIMALS; CALCIUM CHANNELS; GANGLIA, SPINAL; LIGANDS; MICE; MICE, KNOCKOUT; NEURONS, AFFERENT; RECEPTORS, CELL SURFACE; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; UP-REGULATION;

EID: 27844524967     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.014829     Document Type: Article

References (40)

1. 2+ currents in rat sensory neurons. J Neurosci 19:8337-8348.
2. Bao L, Jin SX, Zhang C, Wang LH, Xu ZZ, Zhang FX, Wang LC, Ning FS, Cai HJ, Guan JS, et al. (2003) Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. Neuron 37:121-133.
3. Cahill CM, Morinville A, Hoffert C, O'Donnell D, and Beaudet A (2003) Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain control. Pain 101:199-208.
4. Cahill CM, Morinville A, Lee MC, Vincent JP, Collier B, and Beaudet A (2001) Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J Neurosci 21:7598-7607.
5. Chaillet P, Coulaud A, Zajac JM, Fournie-Zaluski MC, Costentin J, and Roques BP (1984) The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia. Eur J Pharmacol 101:83-90.
6. Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, and Becker AJ (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab Investig 81:913-916.
7. Commons KG (2003) Translocation of presynaptic delta opioid receptors in the ventrolateral periaqueductal gray after swim stress. J Comp Neurol 464:197-207.
8. Eisinger DA, Ammer H, and Schulz R (2002) Chronic morphine treatment inhibits opioid receptor desensitization and internalization. J Neurosci 22:10192-10200.
9. Fields HL, Emson PC, Leigh BK, Gilbert RF, and Iversen LL (1980) Multiple opiate receptor sites on primary afferent fibres. Nature (Lond) 284:351-353.
10. Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gaveriaux-Ruff C, Dierich A, LeMeur M, et al. (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25:195-200.
11. George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of μ- and δ-opioid receptors. Generation of novel functional properties. J Biol Chem 275:26128-26135.
12. Gomes I, Gupta A, Filipovska J, Szeto HH, Pintar JE, and Devi LA (2004) A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci USA 101:5135-5139.
13. He L and Lee NM (1998) Delta opioid receptor enhancement of μ opioid receptor-induced antinociception in spinal cord. J Pharmacol Exp Ther 285:1181-1186.
14. Jordan BA and Devi LA (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature (Lond) 399:697-700.
15. Kolesnikov YA, Jain S, Wilson R, and Pasternak GW (1996) Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance. J Pharmacol Exp Ther 279:502-506.
16. Liu NJ, Xu T, Xu C, Li CQ, Yu YX, Kang HG, and Han JS (1995) Cholecystokinin octapeptide reverses μ-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 275:1293-1299.
17. 3 cells. Mol Pharmacol 59:774-783.
18. Mason P (1999) Central mechanisms of pain modulation. Curr Opin Neurobiol 9:436-441.
19. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dolle P, et al. (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature (Lond) 383:819-823.
20. Matthes HW, Smadja C, Valverde O, Vonesch JL, Foutz AS, Boudinot E, Denavit-Saubie M, Severini C, Negri L, Roques BP, et al. (1998) Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor. J Neurosci 18:7285-7295.
21. Moises HC, Rusin KI, and Macdonald RL (1994) Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons. J Neurosci 14:5903-5916.
22. Nitsche JF, Schuller AG, King MA, Zengh M, Pasternak GW, and Pintar JE (2002) Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci 22:10906-10913.
23. 3 cells by cloned μ- and δ-opioid receptors. Mol Pharmacol 50:947-956.
24. Porreca F, Mosberg HI, Hurst R, Hruby VJ, and Burks TF (1984) Roles of μ, δ and κ opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J Pharmacol Exp Ther 230:341-348.
25. Pradhan AA and Clarke PB (2005) Comparison between delta-opioid receptor functional response and autoradiographic labeling in rat brain and spinal cord. J Comp Neurol 481:416-426.
26. 2+ channels in transfected rat pituitary cells. J Pharmacol Exp Ther 295:552-562.
27. Qiu C, Sora I, Ren K, Uhl G, and Dubner R (2000) Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice. Eur J Pharmacol 387:163-169.
28. Sanchez-Blazquez P, Garcia-Espana A, and Garzon J (1997) Antisense oligodeoxynucleotides to opioid μ and δ receptors reduced morphine dependence in mice: role of δ-2 opioid receptors. J Pharmacol Exp Ther 280:1423-1431.
29. Scherrer G, Befort K, Contet C, Becker J, Matifas A, and Kieffer BL (2004) The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice. Eur J Neurosci 19:2239-2248.
30. 2+ currents, but spares a sustained current. Neuron 6:13-20.
31. Snider WD and McMahon SB (1998) Tackling pain at the source: new ideas about nociceptors. Neuron 20:629-632.
32. Tanowitz M and von Zastrow M (2003) A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. J Biol Chem 278:45978-45986.
33. Walwyn WM, Keith DE Jr, Wei W, Tan AM, Xie CW, Evans CJ, Kieffer BL, and Maidment NT (2004) Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice. Neuroscience 123:111-121.
34. Wang H and Pickel VM (2001) Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. J Neurosci 21:3242-3250.
35. Wang Z, Bilsky EJ, Porreca F, and Sadee W (1994) Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci 54:PL339-PL350.
36. Williams JT, Christie MJ, and Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
37. 2+ channel currents to a μ opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther 311:939-947.
38. Zadina JE, Harrison LM, Ge LJ, Kastin AJ, and Chang SL (1994) Differential regulation of μ and δ opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther 270:1086-1096.
39. Zhang X, Bao L, Arvidsson U, Elde R, and Hokfelt T (1998) Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles. Neuroscience 82:1225-1242.
40. Zhu Y, King MA, Schuller AG, Nitsche JF, Reidl M, Elde RP, Unterwald E, Pasternak GW, and Pintar JE (1999) Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 24:243-252.