δ-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca2+ channels in transfected rat pituitary cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 552-562

  Prather, P L ^a   Song, L ^a   Piros, E T ^a   Law, P Y ^a   Hales, T G ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALKYLATING AGENT; COMPLEMENTARY DNA; DELTA OPIATE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CHANNEL; CALCIUM CURRENT; CALCIUM SIGNALING; CELL CLONE; CELL STRAIN GH3; CONTROLLED STUDY; ENZYME INHIBITION; GENETIC TRANSFECTION; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BINDING; RECEPTOR DENSITY;

ADENYLATE CYCLASE; ALKYLATING AGENTS; ANALGESICS, OPIOID; ANIMAL; BARIUM; CALCIUM CHANNELS, L-TYPE; ENKEPHALIN, D-PENICILLAMINE (2,5)-; FENTANYL; HETEROTRIMERIC GTP-BINDING PROTEINS; ION CHANNELS; NALTREXONE; PITUITARY GLAND; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0033780440     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover
2. 32P]GTP labeling of multiple G protein α subunits
3. 3H]β-funaltrexamine covalent binding in the cloned rat μ opioid receptor
4. Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain
5. Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs
6. Dual coupling of the cloned 5-HT(1A) receptor to both adenylyl cyclase and phospholipase C is mediated via the same G(i) protein
7. Multiple opioid receptors: Ligand selectivity profiles and binding site signatures
8. A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation
9. The GTP binding protein G(o), regulates neuronal calcium channels
10. Coupling of the cloned rat kappa-opioid receptor to adenylyl cyclase is dependent on receptor expression
11. Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia aider carrageenan-induced inflammation
12. Dual excitatory and inhibitory effects of opioids on intracellular calcium in neureblastoma x glioma hybrid NG108-15 cells
13. G protein-coupled receptor heterodimerization modulates receptor function
14. Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents
15. μ- and δ-Opioid receptors differentially couple to G protein subtypes in membranes of human neuro-blastoma cell lines
16. Opiate regulation of adenosine 3',5'-cyclic monophosphate level in neuroblastoma x glioma NG108-15 hybrid cells: Relationship between receptor occupancy and effect
17. Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin
18. Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells
19. μ- and κ-Opioid receptors selectively regulate the same transient components of high-threshold calcium current in rat dorsal root ganglion sensoy neurons
20. 2+ channels by cloned μ- and δ-opioid receptors
21. 2+ channel and adenylyl cyclase modulation by cloned μ-opioid receptors in GH3 cells
22. Functional analysis of cloned opioid receptors in transfected cell lines
23. Interaction of δ-opioid receptors with multiple G proteins: A non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins
24. Properties of a κ-opioid receptor expressed in CHO cells: Interaction with multiple G-proteins is not specific for any individual G(α) subunit and is similar to that of other opioid receptors
25. Ability of δ-opiold receptors to interact with multiple G-proteins is independent of receptor density
26. Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells
27. Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors
28. Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat
29. Identification of three separate guanine nucleotide-binding proteins that interact with δ-opioid receptors in NG108-15 neuroblastoma x glioma hybrid cells
30. 2+ currents and secretion in isolated neuroendocrine nerve terminals
31. Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum
32. 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: In situ identification with G(α) C-terminal antibodies
33. 2+ current in magnocellular neurons of the rat basal forebrain
34. Antibodies as probes of the structure and function of heterotrimeric GTP-binding proteins
35. Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons
36. Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins
37. Differential expression of the β-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: A quantitative evaluation
38. Heterodimerization is required for the formation of a functional GABA(B) receptor
39. Dynorphin A-mediated reduction in multiple calcium currents involves a G(oα)-subtype G protein in rat primary afferent neurons
40. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the δ opioid receptor and determination of its binding domain