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This paper describes the crystal structure of anthrax lethal factor from Bacillus anthracis. The structure reveals a long binding groove specific for the N-terminal tail of members of the MAPK kinase family. It provides structural data for the design of drugs against the acute effects of anthrax infection.
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This paper describes the first structure of a membrane protease, OmpT, from the outer membrane of E. coli. The structure shows a β-barrel fold, typical of outer membrane proteins, with the catalytic site located extracellularly in a groove formed by the extended barrel structure. The catalytic site reveals a novel arrangement of catalytic residues involving one histidine and three aspartate residues.
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