Effects of xenobiotics and peroxisome proliferator-activated receptor-α on the human UDPglucose dehydrogenase gene expression

Journal of Biochemical and Molecular Toxicology

Volumn 19, Issue 5, 2005, Pages 279-288

  Vatsyayan, Jaya ^a   Lee, Shiou Ju ^b   Chang, Hwan You ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

PPAR ; PPRE; Rifampicin; UDPglucose Dehydrogenase; Xenobiotics

Indexed keywords

EUGENOL; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIPERINE; RETINOID X RECEPTOR ALPHA; RIFAMPICIN; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; XENOBIOTIC AGENT;

ARTICLE; BIOINFORMATICS; CATALYSIS; CATALYST; CELL STRAIN HEPG2; EXPRESSION VECTOR; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN MOTIF; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; UGDH GENE; XENOBIOTIC METABOLISM;

BASE SEQUENCE; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PPAR ALPHA; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; XENOBIOTICS;

EID: 27844436635     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20099     Document Type: Article

References (23)

1. Xie W, Uppal H, Saini SP, Mu Y, Little JM, Radominska-Pandya A, Zemaitis MA. Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discov. Today 2004;9:442-449.
2. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347:645-650.
3. Rosen ED, Spiegelman BM. PPARgamma: A nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001;276:37731-37734.
4. Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B. FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity. Gastroenterology 2003;124: 1926-1940.
5. Barbier O, Villeneuve L, Bocher V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B. The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem 2003;278:13975-13983.
6. Reen RK, Jamwal DS, Taneja SC, Koul JL, Dubey RK, Wiebel FJ, Singh J. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine. Biochem Pharmacol 1993;46:229-238.
7. Yokota H, Hashimoto H, Motoya M, Yuasa A. Enhancement of UDP-glucuronyltransferase, UDP-glucose dehydrogenase, and glutathione S-transferase activities in rat liver by dietary administration of eugenol. Biochem Pharmacol 1988;37:799-802.
8. Bontemps Y, Vuillermoz B, Antonicelli F, Perreau C, Danan JL, Maquart FX, Wegrowski Y. Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: Its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. J Biol Chem 2003;278:21566-21575.
9. Vatsyayan J, Peng HL, Chang HY. Analysis of human UDP-glucose dehydrogenase gene promoter: Identification of an Sp1 binding site crucial for the expression of the large transcript. J Biochem 2005;137:703-709.
10. Peng HL, Lou MD, Chang ML, Chang HY. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. Proc Natl Sci Counc Repub China B 1998;22:166-172.
11. Dignam JD, Martin PL, Shastry BS, Roeder RG. Eukaryotic gene transcription with purified components. Methods Enzymol 1983;101:582-598.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
13. Spicer AP, Kaback LA, Smith TJ, Seldin MF. Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. J Biol Chem 1998;273:25117-25124.
14. Black M. Acetaminophen hepatotoxicity. Annu Rev Med 1984;35:577-593.
15. Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 2001;31:55-138.
16. Michalets EL. Update: Clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 1998;18: 84-112.
17. Kocarek TA, Schuetz EG, Strom SC, Fisher RA, Guzelian PS. Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 1995;23:415-421.
18. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 1998;102:1016-1023.
19. Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 1999;56:1329-1339.
20. Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA. Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol Pharmacol 2001;60427-60431.
21. Quandt K, Frech K, Karas H, Wingender E, Werner T. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995;23:4878-4884.
22. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region. J Biol Chem 1997;272:25252-25259.
23. Gbaguidi GF, Agellon LB. The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. Nucleic Acids Res 2004;32:1113-1121.