Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs

Tissue Engineering

Volumn 11, Issue 9-10, 2005, Pages 1297-1311

  Woodfield, Tim B F ^a,b   Van Blitterswijk, C A ^a   De Wijn, J ^b   Sims, T J ^c   Hollander, A P ^c   Riesle, J ^a,d  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d CellCoTec   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPY; BIOMECHANICS; CELLS; DEPOSITION; POROSITY; POROUS MATERIALS; SCAFFOLDS; TISSUE;

ARTICULAR CARTILAGE; CARTILAGE DEFECTS; TISSUE ENGINEERING; VITRO CELL;

BIOMEDICAL ENGINEERING;

COLLAGEN TYPE 2; DNA; GLYCOSAMINOGLYCAN; POLYMER;

ANIMAL CELL; ANIMAL TISSUE; ANISOTROPY; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE CELL; CELL ADHESION; CELLULAR DISTRIBUTION; COW; DNA CONTENT; DYNAMICS; EXTRACELLULAR MATRIX; IN VITRO STUDY; MODEL; NONHUMAN; POROSITY; PRIORITY JOURNAL; TECHNIQUE; TISSUE CULTURE; TISSUE DISTRIBUTION; TISSUE ENGINEERING;

ANIMALS; ANISOTROPY; BIOCOMPATIBLE MATERIALS; CARTILAGE, ARTICULAR; CATTLE; CELL ADHESION; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; DNA; EXTRACELLULAR MATRIX; GLYCOSAMINOGLYCANS; HISTOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MATERIALS TESTING; MODELS, BIOLOGICAL; PHTHALIC ACIDS; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; POROSITY; SURFACE PROPERTIES; TIME FACTORS; TISSUE ENGINEERING;

ANIMALIA; BOVINAE;

EID: 27744606356     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2005.11.1297     Document Type: Article

References (49)

1. Hunziker, E.B. Articular cartilage repair: Are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis Cartilage 7, 15, 1999.
2. Shapiro, F., Koide, S., and Glimcher, M. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg. Am. 75, 532, 1993.
3. Woodfield, T.B.F., Bezemer, J.M., Pieper, J.S., van Blitterswijk, C.A., and Riesle, J. Scaffolds for tissue engineering of cartilage. Crit. Rev. Eukaryot. Gene Expr. 12, 209, 2002.
4. Hunziker, E.B. Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10, 432, 2002.
5. Hunziker, E.B., Quinn, T.M., and Hauselmann, H.J. Quanitative structural organization of normal adult human articular cartilage. Osteoarthritis Cartilage 10, 564, 2002.
6. Mankin, H.J., Mow, V.C., Buckwalter, J.A., Iannotti, J.P., and Ratcliffe, A. Articular cartilage structure, composition and function. In: Buckwalter, J.A., Einhorn, T.A., and Simon, S.R., eds. Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System. Rosemont, IL: American Academy of Orthopaedic Surgeons, 2000, pp. 443.
7. Buckwalter, J., and Mankin, H. Instructional Course Lectures: American Academy of Orthopaedic Surgeons-Articular Cartilage. 1. Tissue design and chondrocyte-matrix interactions. J. Bone Joint Surg. Am. 79, 600, 1997.
8. Ratcliffe, A., Fryer, P.R., and Hardingham, T.E. The distribution of aggregating proteoglycans in articular cartilage: Comparison of quantitative immunoelectron microscopy with radioimmunoassay and biochemical analysis. J. Histochem. Cytochem. 32, 193, 1984.
9. Wong, M., Wuethrich, P., Eggli, P., and Hunziker, E. Zone-specific cell biosynthetic activity in mature bovine articular cartilage: A new method using confocal microscopic stereology and quantitative autoradiography. J. Orthop. Res. 14, 424, 1996.
10. Kim, T.K., Sharma, B., Williams, C.G., Ruffner, M.A., Malik, A., McFarland, E.G., and Elisseeff, J.H. Experimental model for cartilage tissue engineering to regenerate the zonal organization of articular cartilage, Osteoarthritis Cartilage 11, 653, 2003.
11. Waldman, S., Grynpas, M., Pilliar, R., and Kandel, R. The use of specific chondrocyte populations to modulate the properties of tissue-engineered cartilage. J. Orthop. Res, 21, 132, 2003.
12. Mow, V.C., and Wang, C.C. Some bioengineering considerations for tissue engineering of articular cartilage. Clin. Orthop. 367, S204, 1999.
13. Guilak, F., Butler, D.L., and Goldstein, S.A. Functional tissue engineering: The role of biomechanics in articular cartilage repair. Clin. Orthop. 391, S295, 2001.
14. Chen, A., Bae, W., Schinagl, R., and Sah, R. Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression. J. Biomech. 34, 1, 2001.
15. Li, L., Shirazi-Adl, A., and Buschmann, M. Alterations in mechanical behaviour of articular cartilage due to changes in depth varying material properties: a nonhomogeneous poroelastic model study. Comput. Methods Biomech. Biomed. Eng. 5, 45, 2002.
16. Mow, V.C., and Guo, X.E. Mechano-electrochemical properties of articular cartilage: Their inhomogeneities and anisotropies. Annu. Rev. Biomed. Eng. 4, 175, 2002.
17. Treppo, S., Koepp, H., Quan, E.C., Cole, A.A., Kuettner, K.E., and Grodzinsky, A.J. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J. Orthop. Res. 18, 739, 2000.
18. Hubbell, J.A. Bioactive biomaterials. Curr. Opin. Biotechnol. 10, 123, 1999.
19. Hubbell, J.A. Biomaterials in tissue engineering. Biotechnology 13, 565, 1995.
20. Hutmacher, D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 21, 2529, 2000.
21. Lin, A.S., Barrows, T.H., Cartmella, S.H., and Guldberg, R.E. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 24, 481, 2003.
22. Slivka, M.A., Leatherbury, N.C., Kieswetter, K., and Niederauer, G.G. Porous, resorbable, fiber-reinforced scaffolds tailored for articular cartilage repair. Tissue Eng. 7, 767, 2001.
23. Sharma, B., Williams, C.G., Kim, T.K., Malik, A., and Elisseeff, J.H. Multi-layered hydrogel constructs recreate zonal organization of articular cartilage. In: Transactions of the Orthopedic Research Society, 49th Annual Meeting, New Orleans, LA, 2003. Vol. 28, abstract 948.
24. Ng, K., Wang, C.C., Guo, X.E., Ateshian, G.A., and Hung, C.T. Characterization of inhomogeneous bi-layered chondrocyte-seeded agarose constructs of differing agarose concentrations. In; Transactions of the Orthopedic Research Society, 49th Annual Meeting, New Orleans, LA, 2003. Vol. 28, abstract 960.
25. Aydelotte, M., Thonar, E., Mollenhauer, J., and Flechtenmacher, J. Culture of chondrocytes in alginate gel: Variations in conditions of gelation influence the structure of the alginate gel, and the arrangement and morphology of proliferating chondrocytes. In Vitro Cell. Dev. Biol. Anim. 34, 123, 1998.
26. Thomson, B., Smith, M., Boyer, S., Turner, R., Kidd, D., Riggs, H., Dowthwaite, G., and Archer, C. Coated biomaterials, zonal cell-seeding and cartilage tissue engineering. In: Transactions of the Orthopedic Research Society, 48th Annual Meeting, Dallas, TX, 2002. Vol. 27, abstract 477.
27. Klein, T.J., Schumacher, B.L., Li, K.W., Voegtline, M., Masuda, K., Thonar, E.J., and Sah, R.L. Tissue engineered articular cartilage with functional stratification: Targeted delivery of chondrocytes expressing superficial zone protein. In: Transactions of the Orthopedic Research Society, 48th Annual Meeting, Dallas, TX, 2002. Vol. 27, abstract 212.
28. Woodfield, T.B.F., Malda, J., de Wijn, J., PÇters, F., Riesle, J., and van Blitterswijk, C.A. Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique. Biomaterials 25, 4149, 2004.
29. Malda, J., Woodfield, T.B.F., van der Vloodt, F., Wilson, C., Martens, D.E., Tramper, J., van Blitterswijk, C.A., and Riesle, J. The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials 26, 2005.
30. Miot, S., Woodfield, T.B.F., Daniels, A.U., Suetterlin, R., Peterschmitt, I., Heberer, M., van Blitterswijk, C.A., Riesle, J., and Martin, I. Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition. Biomaterials 26, 2005.
31. Vunjak-Novakovic, G., Obradovic, B., Martin, I., Bursac, P., Langer, R., and Freed, L. Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol. Prog. 14, 193, 1998.
32. Papadaki, M., Mahmood, T., Gupta, P., Claase, M.B., Grijpma, D.W., Riesle, J., van Blitterswijk, C.A., and Langer, R. The different behaviors of skeletal muscle cells and chondrocytes on PEGT/PBT block copolymers are related to the surface properties of the substrate. J. Biomed. Mater. Res. 54, 47, 2001.
33. Farndale, R., Buttle, D., and Barrett, A. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim. Biophys. Acta 883, 173, 1986.
34. Hollander, A.P., Heathfield, T.F., Webber, C., Iwata, Y., Bourne, R., Rorabeck, C., and Poole, A.R. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J. Clin. Invest. 93, 1722, 1994.
35. Kafienah, W., and Sims, T.J. Biochemical methods for the analysis of tissue-engineered cartilage. In: Hatton, P.V., and Hollander, A.P., eds. Biopolymer Methods in Tissue Engineering. Totowa, NJ: Humana Press, 2003, p. 217.
36. Malda, J., van Blitterswijk, C.A., Grojec, M., Martens, D.E., Tramper, J., and Riesle, J. Expansion of bovine chondrocytes on microcarriers enhances redifferentiation. Tissue Eng. 9, 939, 2003.
37. Vunjak-Novakovic, G., Martin, I., Obradovic, B., Treppo, S., Grodzinsky, A.J., Langer, R., and Freed. L.E. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. J. Orthop. Res. 17, 130, 1999.
38. Nehrer, S., Breinan, H.A., Ramappa, A., Young, G., Shortkroff, S., Louie, L.K., Sledge, C.B., Yannas, I.V., and Spector, M. Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. Biomaterials 18, 769, 1997.
39. Bhardwaj, T., Pilliar, R., Grynpas, M., and Kandel, R. Effect of material geometry on cartilaginous tissue formation in vitro. J. Biomed. Mater. Res. 57, 190, 2001.
40. LiVecchi, A., Tombes, R., and Laberge, M. In vitro chondrocyte collagen deposition within porous HDPE: Substrate microstructure and wettability effects. J. Biomed. Mater. Res. 28, 839, 1994.
41. Schulze-Tanzil, G., De, S.P., Villegas, C.H., John, T., Merker, H., Scheid, A., and Shakibaei, M. Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tissue Res. 308, 371, 2002.
42. Solursh, M., and Meier, S. Effects of cell density on the expresion of differentiation by chick embryo chondrocytes. J. Exp. Zool. 187, 311, 1974.
43. Gooch, K., Kwon, J., Blunk, T., Langer, R., Freed, L., and Vunjak-Novakovic, G. Effects of mixing intensity on tissue-engineered cartilage. Biotechnol. Bioeng. 72, 402, 2001.
44. Hunziker, E.B., Driesang, I.M., and Saager, C. Structural barrier principle for growth factor-based articular cartilage repair. Clin. Orthop. 391, S182, 2001.
45. Kandel, R., Boyle, J., Gibson, G., Cruz, T., and Speagle, M. In vitro formation of mineralized cartilagenous tissue by articular chondrocytes. In Vitro Cell. Dev. Biol. Anim. 33, 174, 1997.
46. Broom, N.D., Oloyede, A., Flachsmann, R., and Hows, M. Dynamic fracture characteristics of the osteochondral junction undergoing shear deformation. Med. Eng. Phys. 18, 396, 1996.
47. Woodfield, T.B.F., Miot, S., van Blitterswijk, C.A., Riesle, J. The regulation of expanded human nasal chondrocyte redifferentiation capacity by substrate composition and gas plasma surface modification. Biomaterials (in press).
48. Deschamps, A.A., Claase, M.B., Sleijster, W.J., de Bruijn, J.D., Grijpma, D.W., and Feijen, J. Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone. J. Control. Release 78, 175, 2002.
49. Bryant, S., and Anseth, K. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J. Biomed. Mater. Res. 64, 70, 2003.