Sulfur mustard-induced arachidonic acid release is mediated by phospholipase D in human keratinocytes

Biochemical and Biophysical Research Communications

Volumn 295, Issue 5, 2002, Pages 1062-1067

  Lefkowitz, Lee J ^a   Smith, William J ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Arachidonic acid; Phosphatidic acid phosphohydrolase; Phospholipase D; Sulfur mustard

Indexed keywords

ALCOHOL; ARACHIDONIC ACID; MUSTARD GAS; PHOSPHATIDATE PHOSPHATASE; PHOSPHOLIPASE D; PROPRANOLOL;

ARTICLE; CELL SECRETION; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISOTOPE LABELING; KERATINOCYTE; PRIORITY JOURNAL;

ARACHIDONIC ACID; CELLS, CULTURED; DERMATOLOGIC AGENTS; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; KERATINOCYTES; MUSTARD GAS; PHOSPHATIDATE PHOSPHATASE; PHOSPHOLIPASE D; PROPRANOLOL;

EID: 0036343720     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00811-2     Document Type: Article

References (29)

1. Vesicants
2. Putative roles of inflammation in the dermatopathology of sulfur mustard
3. Chemotactic factors released in culture by intact developing and healing skin lesions produced in rabbits by the irritant sulfur mustard
4. Topical sulfur mustard induces changes in prostaglandins and interleukin-1 alpha in isolated perfused porcine skin
5. Sulfur mustard upregulates the expression of interleukin-8 in cultured human keratinocytes
6. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure
7. Mediators initiating the inflammatory response released in organ culture by full-thickness human skin explants exposed to the irritant sulfur mustard
8. Systemic administration of candidate antivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model
9. Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane
10. Regulation of phospholipase A2 by inhibitors
11. The control of free arachidonic acid levels
12. Flow cytometric analysis of toxicity by vesicating agents in human cells in vitro
13. Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells
14. A rapid method of total lipid extraction and purification
15. Phospholipase D: Molecular and cell biology of a novel gene family
16. Arachidonic acid metabolism as a reporter of skin irritancy and target of cancer chemoprevention
17. Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis
18. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
19. Secretory and cytosolic phospholipase A(2)regulate the long-term cytokine-induced eicosanoid production in human keratinocytes
20. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family
21. Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
22. 1,25-Dihydroxyvitamin D3 induces phospholipase D-1 expression in primary mouse epidermal keratinocytes
23. Phospholipase D2: Functional interaction with caveolin in low-density membrane microdomains
24. Localization of phospholipase D in detergent-insoluble, caveolin-rich membrane domains. Modulation by caveolin-1 expression and caveolin-182-101
25. Decreased phospholipase D PLD activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT
26. Sustained phospholipase D activation is associated with keratinocyte differentiation
27. Ultraviolet radiation stimulates a biphasic pattern of 1,2-diacylglycerol formation in cultured human melanocytes and keratinocytes by activation of phospholipases C and D