Protective effect of povidone-iodine ointment against skin lesions induced by sulphur and nitrogen mustards and by non-mustard vesicants

Archives of Toxicology

Volumn 71, Issue 3, 1997, Pages 165-170

  Wormser, Uri ^a   Brodsky, Berta ^a   Green, Bernard S ^a   Arad Yellin, Rina ^b   Nyska, Abraham ^c,d  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c KIMRON VETERINARY INSTITUTE   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Alkylating agents; Antidote; Mustard gas

Indexed keywords

ALKYLATING AGENT; CANTHARIDIN; CHLORMETHINE; DIVINYL SULFONE; IODOACETIC ACID; MUSTARD GAS; POVIDONE IODINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRASSICA; CONTROLLED STUDY; DRUG COMPARISON; DRUG EFFICACY; GUINEA PIG; HISTOPATHOLOGY; MALE; NONHUMAN; OINTMENT; PRIORITY JOURNAL; SKIN DEFECT; SKIN PROTECTION; TOPICAL DRUG ADMINISTRATION;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CHEMICAL WARFARE AGENTS; GUINEA PIGS; IRRITANTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MECHLORETHAMINE; MUSTARD GAS; OINTMENTS; POVIDONE-IODINE; SKIN; SKIN DISEASES;

ANIMALIA; BRASSICA; BRASSICACEAE; CAVIA PORCELLUS; SUS SCROFA;

EID: 0031052420     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050371     Document Type: Article

References (21)

1. Cullumbine H (1946) The mode of penetration of the skin by mustard gas. Br J Dermatol 58: 291-294
2. Dixon M, Needham DM (1946) Biochemical research on chemical warefare agent. Nature 158: 432-438
3. Gold MB, Bongiovanni R, Scharf BA, Gresham VC, Woodward CL (1994) Hypochlorite solution as a decontaminant in sulphur mustard contaminated skin defects in the euthymic hairless guinea pig. Drug Chem Toxicol 17: 499-527
4. Hambrook JL, Howells DJ, Schock C (1993) Biological fate of sulphur mustard (1,1′-thiobis(2-chloroethane)): uptake, distribution and retention of 35S in skin and in blood after cutaneous application of 35S-sulphur mustard in rat and comparison with human blood in vitro. Xenobiotica 23: 537-561
5. Han KH, Maitra AK (1989) Management of partial skin thickness burn wounds with Inadine dressing. Burns 15: 399-402
6. King JR. Monteiro-Riviere NA (1990) Cutaneous toxicity of 2-chloroethyl methyl sulfide in isolated perfused porcine skin. Toxicol Appl Pharmacol 104: 167-179
7. Ludlum DB, Austin-Ritchie P, Hagopian M, Niu TQ, Yu D (1994) Detection of sulfur mustard-induced DNA modifications. Chem Biol Interact 91: 39-49
8. Mershon MM, Mitcheltree LW, Petrali JP, Braue EH, Wade JV (1990) Hairless guinea pig bioassay model for vesicant vapor exposures. Fundam Appl Toxicol 15: 622-630
9. Momeni AZ, Aminjavaheri M (1994) Skin manifestations of mustard gas in a group of 14 children and teenagers: a clinical study. Int J Dermatol 33: 184-187
10. Momeni AZ, Enshaeih S, Meghdadi M, Amindjavaheri M (1992) Skin manifestations of mustard gas. A clinical study of 535 patients exposed to mustard gas [see comments]. Arch Dermatol 128: 775-780
11. Nagy SM, Golumbic C, Stein WH, Fruton JS, Bergmann M (1946) The penetration of vesicant vapors into human skin. J Gen Physiol 29: 441-469
12. Ruhl CM, Park SJ, Danisa O, Morgan RF, Papirmeister B, Sidell FR, Edlich RF, Anthony LS, Himel HN (1994) A serious skin sulfur mustard burn from an artillery shell. J Emerg Med 12: 159-166
13. Smith KJ, Hurst CG, Moeller RB, Skelton HG, Sidell FR (1995) Sulfur mustard: its continuing threat as a chemical warfare agent, the cutaneous lesions induced, progress in understanding its mechanism of action, its long-term health effects, and new developments for protection and therapy. J Am Acad Dermatol 32: 765-776
14. Somani SM, Babu, SR (1989) Therapeutic review, toxicodynamics of sulfur mustard. Int J Clin Pharmacol Ther Toxicol 27: 419-435
15. Vijayaraghavan R, Sugendran K, Pant SC, Husain K, Malhotra RC (1991) Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids. Toxicology 69: 35-42
16. Warthin AS. Weller CV (1918) The pathology of the skin lesions produced by mustard gas (dichloroethylsulphide). J Lab Clin Med 3: 447-479
17. Wormser U (1991) Toxicology of mustard gas. Trends Pharmacol Sci 12: 164-167
18. Wormser U, Green BS, Arad-Yellin R, Brodsky B, Shatz I, Nyska A (1996) In vivo and in vitro toxicity of newly synthesized monofunctional sulfur mustard derivatives. Toxicology 108: 125-128
19. Yourick JJ, Dawson JS, Benton CD, Craig ME, Mitcheltree LW (1993) Pathogenesis of 2,2′-dichlorodiethyl sulfide in hairless guinea pigs. Toxicology 84: 185-197
20. Yourick JJ, Dawson JS, Mitcheltree LW (1995) Reduction of erythema in hairless guinea pigs after cutaneous sulfur mustard vapor exposure by pretreatment with niacinamide, promethazine and indomethacin. J Appl Toxicol 15: 133-138
21. Zhang Z, Riviere JE, Monteiro-Riviere NA (1995) Evaluation of protective effects of sodium thiosulfate, cysteine, niacinamide and indomethacin on sulfur mustard-treated isolated perfused porcine skin. Chem Biol Interact 96: 249-262