Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog

Journal of Biochemical and Molecular Toxicology

Volumn 17, Issue 2, 2003, Pages 114-121

  Chatterjee, Diptendu ^a   Mukherjee, Shyamali ^a   Smith, Milton G ^b   Das, Salil K ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b AMAOX Ltd   (United States)

Author keywords

2 Chloroethyl ethyl sulfide (CEES); Apoptosis; Capases; Ceramides; Lung injury; NF B; Sphingomyelinase; TNF

Indexed keywords

2 CHLOROETHYLETHYLSULFIDE; CASPASE; CERAMIDE; CHEMICAL WARFARE AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUSTARD GAS DERIVATIVE; PROTEIN P50; SPHINGOMYELIN PHOSPHODIESTERASE; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALYTICAL ERROR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; MALE; NONHUMAN; SIGNAL TRANSDUCTION; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, INHALATION; ANIMALS; APOPTOSIS; CASPASES; CERAMIDES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GUINEA PIGS; INTUBATION, INTRATRACHEAL; LUNG; LUNG DISEASES; MALE; MUSTARD GAS; NF-KAPPA B; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR-ALPHA;

CAVIA;

EID: 0037648971     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.10068     Document Type: Article

References (40)

1. Debrowska MI, Becks LL, Lelli JL, Levee MG, Hinshaw DB. Sulfur mustard induces apoptosis and necrosis in endothelial cells. Toxicol Appl Pharmacol 1996;141:568-583.
2. Dacre JC, Goldman M. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol Rev 1996;48:289-326.
3. Elsayed NM, Ta PN, Korte DW. Biochemical alterations in mouse liver induced by nitrogen mustard. Toxicologist 1989;9:26-34.
4. Elsayed NM, Omaye ST, Klain GJ, Inase JL, Dahlberg ET, Wheeler CR, Korte DW. Response of mouse brain to a single subcutaneous injection of the monofunctional sulfur mustard, butyl-2-chloroethyl sulfide (BCS). Toxicology 1989;58:11-20.
5. Calvet JH, Jarrean PH, Levame M, D'ortho MP, Lorino H, Harf A, Mavier IM. Acute and chronic respiratory effects of sulfur mustard intoxication in guinea pigs. J Appl Physiol 1994;76:681-688.
6. Momeni AZ, Enshaelh S, Meghdadi SM, Amindjavaheri M. Skin manifestation of mustard gas. Clinical study of 535 patients exposed to mustard gas. Arch Dermatol 1992;128:775-780.
7. Dixon M, Needham DM. Biochemical research on chemical warfare agents. Nature 1946;158:432-433.
8. Yamakido M, Ishinka. S, Hiyama K, Maeda A. Former poison gas workers and cancer: Incidence and inhibition of tumor formation by treatment with biological response modifier N-CWS. Environ Health Perspect 1996;104(Suppl.):485-488.
9. Adachi S, Takemoto K. Occupational lung cancer. A comparison between humans and experimental animals. Sangyo Igaku 1987;29:345-357.
10. Sasser LB, Cushing JA, Dacre JC. Two-generation reproduction study of sulfur mustard in rats. Reprod Toxicol 1996;10:311-319.
11. Elsayed NM, Omaye ST, Klain GJ, Korte DW. Free radical-mediated lung response to the monofunctional sulfur mustard butyl 2-chloroethyl sulfide after subcutaneous injection. Toxicology 1992;72:153-165.
12. Cowan FM, Broomfield CA. Putative roles of inflammation in the dermatopathology of sulfur mustard. Cell Biol Toxicol 1993;9:201-213.
13. Husain K, Dube SN, Sugendran K, Singh R, Das Gupta S, Somani SM. Effect of topically applied sulphur mustard on antioxidant enzymes in blood cells and body tissues of rats. J Appl Toxicol 1996;16:245-248.
14. Kopff M, Zakrzewska I, Strzelczyk M, Klem J, Dubiecki W. Superoxide dismutase and catalase activity in psoriatic patients treated topically with ointment containing 2-chloroethyl-3-chloropropyl sulfide. Pol J Pharmacol 1994;46:439-444.
15. Kuhns DB, Decarlo E, Hawk DM, Gallin JI. Dynamics of the cellular and humoral components of the inflammatory response elicited in skin blisters in humans. J Clin Invest 1992;89:1734-1740.
16. Arroyo CM, Von Tersch RL, Broomfield CA. Activation of alpha-human tumor necrosis factor (TNF-alpha) by human monocytes (THP-1) exposed to 2-chloroethyl ethyl sulfide (H-MG). Hum Exp Toxicol 1995;14:547-553.
17. Ricketts KM, Santai CT, France JA, Graziosi AM, Doyel TD, Gazaway MY, Casillas RP. Inflammatory cytokine response in sulfur mustard-exposed mouse skin. J Appl Toxicol 2000;20(Suppl. 1):S73-S76.
18. Stith IE, Das SK. Development of cholinephosphotransferase in guinea pig lung mitochondria and microsomes. Biochem Biophys Acta 1982;714:250-256.
19. Khan AQ, Sikpi MO, Das SK. Phospholipid composition of guinea pig lung lavage. Lipids 1985;20:7-10.
20. Gulbins E, Kolesnick R. Measurement of sphingomyelinase activity Methods Enzymol 2000;322:382-388.
21. Cao LC, Honeyman T, Jonassen J, Scheid C. Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cells. Kidney Int 2000;57:2403-2411.
22. Mackay F, Majeau GR, Hochman PS, Browning JL. Lymphotoxin receptor triggering induces activation of the nuclear factor kB transcription factor in some cell type. J Biol Chem 1996;271:24934-24938.
23. Steel RGD, Torrie JH. In: Principles and Procedures of Statistics: A Biometric Approach, 2nd edition, New York: McGraw-Hill Book Co.; 1980. pp 86-121.
24. Orlov SN, Tremblay J, Deblois D, Hamet P. Genetics of programmed cell death and proliferation. Semin Nephrol 2002;22:161-171.
25. Liversidge J, Dick A, Gordon S. Nitric oxide mediates apoptosis through formation of peroxynitrite and fas/fas-ligand interactions in experimental autoimmune uveitis. Am J Pathol 2002;160:905-916.
26. Puig B, Ferrer I. Caspase-3-associated apoptotic cell death in excitotoxic necrosis of the entorhinal cortex following intraperitoneal injection of kainic acid in the rat. Neurosci Lett 2001;321:182-186.
27. Helal MA, Mehmet H, Thomas NS, Cox PM, Ralph DJ, Bajoria R, Chatterjee R. Ontogeny of human fetal testicular apoptosis during first, second, and third trimesters of pregnancy. J Clin Endocrinol Metab 2002;87:1189-1193.
28. Earnshaw WC, Martin LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates and functions during apoptosis. Annu Rev Biochem 1999;68:383-424.
29. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.
30. Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998;60:643-665.
31. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR. Loss of ceramide production confers resistance to rediation induced apoptosis. Cancer Res 1997;57:1270-1275.
32. Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid degradation break down product in cellular regulation. Science 1976;243:500-507.
33. Shang J, Eberle J, Geilen CC, Hossini AM, Fecker LF, Orfanos CE, Tebbe B. The role of nuclear factor-kappa B and melanogenesis in tumor necrosis factor-alpha-induced apoptosis of normal human melanocytes. Skin Pharmacol Appl Skin Physiol 2002;15:321-329.
34. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α induced cell death. Science 1996;274:782-787.
35. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A, Brenner DA, Czaja MJ. NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis. Am J Physiol 1998;275:1058-1066.
36. Plumpe J, Malek NP, Bock CT, Rakemann T, Manns MP, Trautwein C. NF-κB determines between apoptosis and proliferation in hepatocytes during liver regeneration. Am J Physiol 2000;278:173-183.
37. Vogt RF, Dannenberg AM, Schofield BH, Hynes NA, Papirmeister B. Pathogenesis of skin lesions caused by sulfur mustard. Fundam Appl Toxicol 1984;4:S71-S83.
38. Alphonse G, Aloy MT, Broquet P, Gerard JP, Louisot P, Rousson R, Rodriguez-Lafrasse C. Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells. Int J Radiat Biol 2002;78:821-835.
39. Hetz CA, Hunn M, Rojas P, Torres V, Leyton L, Quest AF. Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: Onset of necrosis is associated with delayed ceramide increase. J Cell Sci 2002;115:4671-4683.
40. Hearps AC, Burrows J, Connor CE, Woods GM, Lowenthal RM, Ragg SJ. Mitochondrial cytochrome c release precedes transmembrane depolarization and caspase-3 activation during ceramide-induced apoptosis in Jurkat T cells. Apoptosis 2002;7:387-394.