메뉴 건너뛰기




Volumn 110, Issue 9, 2003, Pages 1013-1027

Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

Author keywords

Cerebral cortex human; Excitotoxicity; Neurodegeneration; Pathogenesis; Transporters glutamate

Indexed keywords

ASPARTIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; TRITIUM;

EID: 0041911085     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0012-z     Document Type: Article
Times cited : (40)

References (54)
  • 1
  • 2
    • 0034637146 scopus 로고    scopus 로고
    • Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter
    • Bellocchio EE, Reimer RJ, Fremeau RTJ, Edwards RH (2000) Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289: 957-960
    • (2000) Science , vol.289 , pp. 957-960
    • Bellocchio, E.E.1    Reimer, R.J.2    Fremeau, R.T.J.3    Edwards, R.H.4
  • 3
    • 0000601825 scopus 로고
    • Radioligand-receptor binding studies: What's wrong with Scatchard analysis?
    • Bürgisser E (1984) Radioligand-receptor binding studies: what's wrong with Scatchard analysis? Trends Pharmacol Sci 5: 142-144
    • (1984) Trends Pharmacol Sci , vol.5 , pp. 142-144
    • Bürgisser, E.1
  • 4
    • 0025138490 scopus 로고
    • Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type
    • Chalmers DT, Dewar D, Graham DI, Brooks DN, McCulloch J (1990) Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type. Proc Natl Acad Sci USA 87: 1352-1356
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1352-1356
    • Chalmers, D.T.1    Dewar, D.2    Graham, D.I.3    Brooks, D.N.4    McCulloch, J.5
  • 5
    • 0023939425 scopus 로고
    • Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease
    • Cowburn RF, Hardy JA, Roberts PJ, Briggs R (1988) Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease. Brain Res 452: 403-407
    • (1988) Brain Res , vol.452 , pp. 403-407
    • Cowburn, R.F.1    Hardy, J.A.2    Roberts, P.J.3    Briggs, R.4
  • 7
    • 0028143148 scopus 로고
    • The high affinity uptake system for excitatory amino acids in the brain
    • Danbolt NC (1994) The high affinity uptake system for excitatory amino acids in the brain. Prog Neurobiol 44: 377-396
    • (1994) Prog Neurobiol , vol.44 , pp. 377-396
    • Danbolt, N.C.1
  • 8
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65: 1-105
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 9
    • 0022529283 scopus 로고
    • +-dependent "binding" of D-aspartate in brain membranes is largely due to uptake into membrane-bounded saccules
    • +-dependent "binding" of D-aspartate in brain membranes is largely due to uptake into membrane-bounded saccules. J Neurochem 47: 819-824
    • (1986) J Neurochem , vol.47 , pp. 819-824
    • Danbolt, N.C.1    Storm-Mathisen, J.2
  • 10
    • 0021848540 scopus 로고
    • Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate
    • de Boni U, Crapper-McLachlan DR (1985) Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate. J Neurol Sci 68: 105-118
    • (1985) J Neurol Sci , vol.68 , pp. 105-118
    • De Boni, U.1    Crapper-McLachlan, D.R.2
  • 11
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • Doble A (1999) The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 81: 163-221
    • (1999) Pharmacol Ther , vol.81 , pp. 163-221
    • Doble, A.1
  • 13
    • 0022724623 scopus 로고
    • Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain
    • Dodd PR, Hardy JA, Baig EB, Kidd AM, Bird ED, Watson WEJ, Johnston GAR (1986) Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain. Neurochem Pathol 4: 177-198
    • (1986) Neurochem Pathol , vol.4 , pp. 177-198
    • Dodd, P.R.1    Hardy, J.A.2    Baig, E.B.3    Kidd, A.M.4    Bird, E.D.5    Watson, W.E.J.6    Johnston, G.A.R.7
  • 14
    • 0024339959 scopus 로고
    • Uptake of γ-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: Multiple sites, sodium dependence and effect of tissue preparation
    • Dodd PR, Watson WEJ, Morrison MM, Johnston GAR, Bird ED, Cowburn RF, Hardy JA (1989) Uptake of γ-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation. Brain Res 490: 320-331
    • (1989) Brain Res , vol.490 , pp. 320-331
    • Dodd, P.R.1    Watson, W.E.J.2    Morrison, M.M.3    Johnston, G.A.R.4    Bird, E.D.5    Cowburn, R.F.6    Hardy, J.A.7
  • 15
    • 0026673536 scopus 로고
    • Amino acid neurotransmitter receptor changes in cerebral cortex in alcoholism: Effect of cirrhosis of the liver
    • Dodd PR, Thomas GJ, Harper CG, Kril JJ (1992) Amino acid neurotransmitter receptor changes in cerebral cortex in alcoholism: effect of cirrhosis of the liver. J Neurochem 59: 1506-1515
    • (1992) J Neurochem , vol.59 , pp. 1506-1515
    • Dodd, P.R.1    Thomas, G.J.2    Harper, C.G.3    Kril, J.J.4
  • 16
    • 0035047753 scopus 로고    scopus 로고
    • Release of D,L-threo-β-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals
    • Fleck MW, Barrionuevo G, Palmer AM (2001a) Release of D,L-threo-β-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals. Neurochem Int 39: 75-81
    • (2001) Neurochem Int , vol.39 , pp. 75-81
    • Fleck, M.W.1    Barrionuevo, G.2    Palmer, A.M.3
  • 17
    • 0034977367 scopus 로고    scopus 로고
    • Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate
    • Fleck MW, Barrionuevo G, Palmer AM (2001b) Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate. Neurochem Int 39: 217-225
    • (2001) Neurochem Int , vol.39 , pp. 217-225
    • Fleck, M.W.1    Barrionuevo, G.2    Palmer, A.M.3
  • 18
    • 0026518395 scopus 로고
    • Inhibition of L-glutamate uptake into synaptic vesicles
    • Fykse EM, Iversen EG, Fonnum F (1992) Inhibition of L-glutamate uptake into synaptic vesicles. Neurosci Lett 135: 125-128
    • (1992) Neurosci Lett , vol.135 , pp. 125-128
    • Fykse, E.M.1    Iversen, E.G.2    Fonnum, F.3
  • 19
    • 0024363934 scopus 로고
    • Excitatory amino acids and Alzheimer's disease
    • Greenamyre JT, Young AB (1989) Excitatory amino acids and Alzheimer's disease. Neurobiol Aging 10: 593-602
    • (1989) Neurobiol Aging , vol.10 , pp. 593-602
    • Greenamyre, J.T.1    Young, A.B.2
  • 20
    • 0032529722 scopus 로고    scopus 로고
    • Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus
    • Gundersen V, Chaudhry FA, Bjaalie JG, Fonnum F, Ottersen OP, Storm-Mathisen J (1998) Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. J Neurosci 18: 6059-6070
    • (1998) J Neurosci , vol.18 , pp. 6059-6070
    • Gundersen, V.1    Chaudhry, F.A.2    Bjaalie, J.G.3    Fonnum, F.4    Ottersen, O.P.5    Storm-Mathisen, J.6
  • 21
    • 0020579323 scopus 로고
    • Metabolic and functional studies on post-mortem human brain
    • Hardy JA, Dodd PR (1983) Metabolic and functional studies on post-mortem human brain. Neurochem Int 5: 253-266
    • (1983) Neurochem Int , vol.5 , pp. 253-266
    • Hardy, J.A.1    Dodd, P.R.2
  • 24
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225: 1168-1170
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 25
    • 0023270663 scopus 로고
    • Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone
    • Hyman BT, van Hoesen GW, Damasio AR (1987) Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone. Ann Neurol 22: 37-40
    • (1987) Ann Neurol , vol.22 , pp. 37-40
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3
  • 26
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42: 1097-1105
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 27
    • 26444489781 scopus 로고    scopus 로고
    • Vesicular glutamate transporter 1 in Alzheimer's disease
    • Abstr Viewer 785.15 (Abstract)
    • Kirvell SL, Fremeau RT, Francis PT (2002) Vesicular glutamate transporter 1 in Alzheimer's disease. Soc Neurosci 2002 Abstr Viewer 785.15 (Abstract)
    • (2002) Soc Neurosci 2002
    • Kirvell, S.L.1    Fremeau, R.T.2    Francis, P.T.3
  • 28
    • 0024803096 scopus 로고
    • Glutamate accumulation into synaptic vesicles
    • Kish PE, Ueda T (1989) Glutamate accumulation into synaptic vesicles. Meth Enzymol 174: 9-25
    • (1989) Meth Enzymol , vol.174 , pp. 9-25
    • Kish, P.E.1    Ueda, T.2
  • 29
    • 0030872412 scopus 로고    scopus 로고
    • Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
    • Li S, Mallory M, Alford M, Tanaka S, Masliah E (1997) Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. J Neuropathol Exp Neurol 56: 901-911
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 901-911
    • Li, S.1    Mallory, M.2    Alford, M.3    Tanaka, S.4    Masliah, E.5
  • 30
    • 0025054474 scopus 로고
    • Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease
    • Lowe SL, Bowen DM, Francis PT, Neary D (1990) Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience 38: 571-577
    • (1990) Neuroscience , vol.38 , pp. 571-577
    • Lowe, S.L.1    Bowen, D.M.2    Francis, P.T.3    Neary, D.4
  • 32
    • 0021847557 scopus 로고
    • Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age
    • Mann DMA, Yates PO, Marcyniuk B (1985) Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age. J Neurol Sci 69: 139-159
    • (1985) J Neurol Sci , vol.69 , pp. 139-159
    • Mann, D.M.A.1    Yates, P.O.2    Marcyniuk, B.3
  • 33
    • 0018178434 scopus 로고
    • A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
    • Markwell MA, Haas SM, Bieber LL, Tolbert NE (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 87: 206-210
    • (1978) Anal Biochem , vol.87 , pp. 206-210
    • Markwell, M.A.1    Haas, S.M.2    Bieber, L.L.3    Tolbert, N.E.4
  • 34
    • 0029811226 scopus 로고    scopus 로고
    • Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
    • Masliah E, Alford M, Deteresa R, Mallory M, Hansen L (1996) Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40: 759-766
    • (1996) Ann Neurol , vol.40 , pp. 759-766
    • Masliah, E.1    Alford, M.2    Deteresa, R.3    Mallory, M.4    Hansen, L.5
  • 35
    • 0033034192 scopus 로고    scopus 로고
    • The modulatory effect of spermine on the glutamate-NMDA receptor is regionally variable in normal human adult cerebral cortex
    • Mortensen M, Dodd PR (1999) The modulatory effect of spermine on the glutamate-NMDA receptor is regionally variable in normal human adult cerebral cortex. Pharmacol Toxicol 84: 135-142
    • (1999) Pharmacol Toxicol , vol.84 , pp. 135-142
    • Mortensen, M.1    Dodd, P.R.2
  • 36
    • 0020956552 scopus 로고
    • Cortical neuronal counts in normal elderly controls and demented patients
    • Mountjoy CQ, Roth M, Evans NJ, Evans HM (1983) Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging 4: 1-11
    • (1983) Neurobiol Aging , vol.4 , pp. 1-11
    • Mountjoy, C.Q.1    Roth, M.2    Evans, N.J.3    Evans, H.M.4
  • 37
    • 0021965984 scopus 로고
    • Characterization of glutamate uptake into synaptic vesicles
    • Naito S, Ueda T (1985) Characterization of glutamate uptake into synaptic vesicles. J Neurochem 44: 99-109
    • (1985) J Neurochem , vol.44 , pp. 99-109
    • Naito, S.1    Ueda, T.2
  • 38
    • 0027031286 scopus 로고
    • Neuroreceptor changes in Alzheimer disease
    • Nordberg A (1992) Neuroreceptor changes in Alzheimer disease. Cerebrovasc Brain Metab Rev 4: 303-328
    • (1992) Cerebrovasc Brain Metab Rev , vol.4 , pp. 303-328
    • Nordberg, A.1
  • 39
    • 0025366890 scopus 로고
    • A quantitative electron microscopic immunocytochemical study of the distribution and synaptic handling of glutamate in rat hippocampus
    • Ottersen OP, Storm-Mathisen J, Bramham C, Torp R, Laake JH, Gundersen V (1990) A quantitative electron microscopic immunocytochemical study of the distribution and synaptic handling of glutamate in rat hippocampus. Prog Brain Res 83: 99-114
    • (1990) Prog Brain Res , vol.83 , pp. 99-114
    • Ottersen, O.P.1    Storm-Mathisen, J.2    Bramham, C.3    Torp, R.4    Laake, J.H.5    Gundersen, V.6
  • 40
    • 0022521048 scopus 로고
    • Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease
    • Palmer AM, Procter AW, Stratmann GC, Bowen DM (1986) Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease. Neurosci Lett 66: 199-204
    • (1986) Neurosci Lett , vol.66 , pp. 199-204
    • Palmer, A.M.1    Procter, A.W.2    Stratmann, G.C.3    Bowen, D.M.4
  • 41
    • 0023228728 scopus 로고
    • 3H]glutamate to repeatedly frozen-thawed rat brain membranes
    • 3H] glutamate to repeatedly frozen-thawed rat brain membranes. Neurochem Int 11: 69-75
    • (1987) Neurochem Int , vol.11 , pp. 69-75
    • Periyasamy, S.1    Ito, M.2    Chiu, T.H.3
  • 42
    • 0019350983 scopus 로고
    • Postmortem changes of amino compounds in human and rat brain
    • Perry TL, Hansen S, Gandham SS (1981) Postmortem changes of amino compounds in human and rat brain. J Neurochem 36: 406-410
    • (1981) J Neurochem , vol.36 , pp. 406-410
    • Perry, T.L.1    Hansen, S.2    Gandham, S.S.3
  • 44
    • 0036312870 scopus 로고    scopus 로고
    • NMDA receptor is differentially responsive to conantokins in normal and Alzheimer disease human cerebral cortex
    • NMDA receptor is differentially responsive to conantokins in normal and Alzheimer disease human cerebral cortex. J Neurochem 81: 765-779
    • (2002) J Neurochem , vol.81 , pp. 765-779
    • Ragnarsson, L.1    Mortensen, M.2    Dodd, P.R.3    Lewis, R.J.4
  • 45
    • 0028980624 scopus 로고
    • Uptake of L-glutamate into rat brain synaptic vesicles: Effect of inhibitors that bind specifically to the glutamate transporter
    • Roseth S, Fykse EM, Fonnum F (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. J Neurochem 65: 96-103
    • (1995) J Neurochem , vol.65 , pp. 96-103
    • Roseth, S.1    Fykse, E.M.2    Fonnum, F.3
  • 46
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman SM, Olney JW (1986) Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19: 105-111
    • (1986) Ann Neurol , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 47
    • 0022588911 scopus 로고
    • Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type
    • Sasaki H, Muramoto O, Kanazawa I, Arai H, Kosaka K, Iizuka R (1986) Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type. Ann Neurol 19: 263-269
    • (1986) Ann Neurol , vol.19 , pp. 263-269
    • Sasaki, H.1    Muramoto, O.2    Kanazawa, I.3    Arai, H.4    Kosaka, K.5    Iizuka, R.6
  • 48
    • 0028961895 scopus 로고
    • Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex
    • Scott HL, Tannenberg AEG, Dodd PR (1995) Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex. J Neurochem 64: 2193-2202
    • (1995) J Neurochem , vol.64 , pp. 2193-2202
    • Scott, H.L.1    Tannenberg, A.E.G.2    Dodd, P.R.3
  • 49
    • 0036479889 scopus 로고    scopus 로고
    • Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    • Scott HL, Pow DV, Tannenberg AEG, Dodd PR (2002) Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease. J Neurosci 22: RC206 (1-5)
    • (2002) J Neurosci , vol.22 , Issue.1-5 RC206
    • Scott, H.L.1    Pow, D.V.2    Tannenberg, A.E.G.3    Dodd, P.R.4
  • 51
    • 0020611657 scopus 로고
    • Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease
    • Smith CCT, Bowen DM, Sims NR, Neary D, Davison AN (1983) Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. Brain Res 264: 138-141
    • (1983) Brain Res , vol.264 , pp. 138-141
    • Smith, C.C.T.1    Bowen, D.M.2    Sims, N.R.3    Neary, D.4    Davison, A.N.5
  • 52
    • 0037316679 scopus 로고    scopus 로고
    • The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings
    • Suchak SK, Baloyianni NV, Perkinton MS, Williams RJ, Meldrum BS, Rattray M (2003) The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. J Neurochem 84: 522-532
    • (2003) J Neurochem , vol.84 , pp. 522-532
    • Suchak, S.K.1    Baloyianni, N.V.2    Perkinton, M.S.3    Williams, R.J.4    Meldrum, B.S.5    Rattray, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.