An activin-A/C chimera exhibits activin and myostatin antagonistic properties

Journal of Biological Chemistry

Volumn 280, Issue 44, 2005, Pages 36626-36632

  Muenster, Uwe ^a   Harrison, Craig A ^b   Donaldson, Cynthia ^a   Vale, Wylie ^a   Fischer, Wolfgang H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELL CULTURE; CELLS; CONCENTRATION (PROCESS); GROWTH KINETICS; HORMONES;

ACTIVIN-A/C CHIMERA; LIGAND; MYOSTATIN; REPORTER ASSAY;

PROTEINS;

ACTIVIN; ACTIVIN A; ACTIVIN C; ACTIVIN RECEPTOR 1; ACTIVIN RECEPTOR 2; FOLLITROPIN; LIGAND; MUTANT PROTEIN; MYOSTATIN; PROTEIN SERINE KINASE; RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; BETA SHEET; CHIMERA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FOLLITROPIN RELEASE; HUMAN; HUMAN CELL; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ACTIVIN RECEPTORS, TYPE II; ACTIVINS; AMINO ACID SEQUENCE; ANIMALS; BETA-GALACTOSIDASE; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; FOLLICLE STIMULATING HORMONE; FOLLISTATIN; HUMANS; KIDNEY; LIGANDS; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PITUITARY GLAND, ANTERIOR; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 27744516899     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507236200     Document Type: Article

References (34)

1. Schier, A. F., and Shen, M. M. (2000) Nature 403, 385-389
2. Chen, Y. G., Lui, H. M., Lin, S. L., Lee, J. M., and Ying, S. Y. (2002) Exp. Biol. Med. (Maywood) 227, 75- 87
3. Massague, J. (1998) Annu. Rev. Biochem. 67, 753-791
4. Risbridger, G. P., Schmitt, J. F., and Robertson, D. M. (2001) Endocr. Rev. 22, 836-858
5. Werner, S., and Grose, R. (2003) Physiol. Rev. 83, 835-870
6. Shi, Y., and Massague, J. (2003) Cell 113, 685-700
7. Vitt, U. A., Hsu, S. Y., and Hsueh, A. J. (2001) Mol. Endocrinol. 15, 681-694
8. Greenwald, J., Vega, M. E., Allendorph, G. P., Fischer, W. H., Vale, W., and Choe, S. (2004) Mol. Cell 15, 485-489
9. Thompson, T. B., Woodruff, T. K., and Jardetzky, T. S. (2003) EMBO J. 22, 1555-1566
10. Phillips, D. J. (2000) Bioessays 22, 689-696
11. Vejda, S., Cranfield, M., Peter, B., Mellor, S. L., Groome, N., Schulte-Hermann, R., and Rossmanith, W. (2002) J. Mol. Endocrinol. 28, 137-148
12. Mellor, S. L., Cranfield, M., Ries, R., Pedersen, J., Cancilla, B., de Kretser, D., Groome, N. P., Mason, A. J., and Risbridger, G. P. (2000) J. Clin. Endocrinol. Metab. 85, 4851-4858
13. Mellor, S. L., Ball, E. M., O'Connor, A. E., Ethier, J. F., Cranfield, M., Schmitt, J. F., Phillips, D. J., Groome, N. P., and Risbridger, G. P. (2003) Endocrinology 144, 4410-4419
14. Lau, A. L., Kumar, T. R., Nishimori, K., Bonadio, J., and Matzuk, M. M. (2000) Mol. Cell. Biol. 20, 6127-6137
15. Chabicovsky, M., Herkner, K., and Rossmanith, W. (2003) Endocrinology 144, 3497-3504
16. Vejda, S., Erlach, N., Peter, B., Drucker, C., Rossmanith, W., Pohl, J., Schulte-Hermann, R., and Grusch, M. (2003) Carcinogenesis 24, 1801-1809
17. Wada, W., Maeshima, A., Zhang, Y. Q., Hasegawa, Y., Kuwano, H., and Kojima, I. (2004) Am. J. Physiol. 287, E247-E254
18. Massague, J. (2000) Nat. Rev. Mol. Cell. Biol 1, 169-178
19. Lebrun, J. J., and Vale, W. W. (1997) Mol. Cell. Biol. 17, 1682-1691
20. Attisano, L., Wrana, J. L., Montalvo, E., and Massague, J. (1996) Mol. Cell. Biol. 16, 1066-1073
21. Greenwald, J., Groppe, J., Gray, P., Wiater, E., Kwiatkowski, W., Vale, W., and Choe, S. (2003) Mol. Cell 11, 605-617
22. Wuytens, G., Verschueren, K., de Winter, J. P., Gajendran, N., Beek, L., Devos, K., Bosman, F., de Waele, P., Andries, M., van den Eijnden-van Raaij, A. J., Smith, J. C., and Huylebroeck, D. (1999) J. Biol. Chem. 274, 9821-9827
23. Kirsch, T., Sebald, W., and Dreyer, M. K. (2000) Nat. Struct. Biol. 7, 492-496
24. Kirsch, T., Nickel, J., and Sebald, W. (2000) EMBO J. 19, 3314-3324
25. Keller, S., Nickel, J., Zhang, J. L., Sebald, W., and Mueller, T. D. (2004) Nat. Struct. Mol. Biol. 11, 481-488
26. Harrison, C. A., Gray, P. C., Fischer, W. H., Donaldson, C., Choe, S., and Vale, W. (2004) J. Biol. Chem. 279, 28036-28044
27. Durocher, Y., Perret, S., and Kamen, A. (2002) Nucleic Acids Res. 30, e9
28. Fischer, W. H., Park, M., Donaldson, C., Wiater, E., Vaughan, J., Bilezikjian, L. M., and Vale, W. (2003) J. Endocrinol. 176, 61-68
29. Vale, W., Vaughan, J., Yamamoto, G., Bruhn, T., Douglas, C., Dalton, D., Rivier, C., and Rivier, J. (1983) Methods Enzymol. 103, 565-577
30. Schuelke, M., Wagner, K. R., Stolz, L. E., Hubner, C., Riebel, T., Kornen, W., Braun, T., Tobin, J. F., and Lee, S. J. (2004) N. Engl. J. Med. 350, 2682-2688
31. Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., and Attisano, L. (2003) Mol. Cell. Biol. 23, 7230-7242
32. Butler, C. M., Gold, E. J., and Risbridger, G. P. (2005) Cytokine Growth Factor Rev. 16, 377-385
33. Knaus, P., and Sebald, W. (2001) Biol. Chem. 382, 1189-1195
34. Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., Cheng, G.-X., Wrana, J. L., Massague, J., and Rosenbaum, J. S. (1994) Mol. Cell. Biol. 14, 5961-5974