Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

Journal of Biological Chemistry

Volumn 280, Issue 44, 2005, Pages 37246-37256

  Goto, Masaru ^a   Miyahara, Ikuko ^a   Hirotsu, Ken ^a   Conway, Myra ^b   Yennawar, Neela ^c   Islam, Mohammad M ^b   Hutson, Susan M ^b  

^a Osaka Prefecture University   (Japan)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; DRUG PRODUCTS; ENZYME INHIBITION; ENZYME KINETICS; NEUROLOGY; OXIDATION; REACTION KINETICS; STRUCTURAL ANALYSIS;

BRANCHED-CHAIN AMINOTRANSFERASE; ISOZYMES; MITOCHONDRIAL ENZYMES; NEUROACTIVE DRUG GABAPENTIN;

BIOCHEMISTRY;

2 OXOACID; 2 OXOGLUTARIC ACID; AMINOTRANSFERASE; ANTICONVULSIVE AGENT; DITHIOTHREITOL; GABAPENTIN; GLUTAMIC ACID; ISOCAPROIC ACID; ISOENZYME; ISOLEUCINE; LEUCINE; MITOCHONDRIAL ENZYME; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VALINE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; DISULFIDE BOND; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; OXIDATION; PRIORITY JOURNAL; STEADY STATE; THREE DIMENSIONAL IMAGING; TRANSAMINATION;

AMINES; AMINO ACID SEQUENCE; ANTICONVULSANTS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANECARBOXYLIC ACIDS; CYTOSOL; DITHIOTHREITOL; GAMMA-AMINOBUTYRIC ACID; ISOENZYMES; ISOLEUCINE; LYSINE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRANSAMINASES; VALINE;

EID: 27744496522     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506486200     Document Type: Article

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