Neuroprotective role of neurotrophins: Relationship between nerve growth factor and apoptotic cell survival pathway after cerebral ischemia

Current Atherosclerosis Reports

Volumn 7, Issue 4, 2005, Pages 268-273

  Saito, Atsushi ^a   Tominaga, Teiji ^b   Chan, Pak H ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; K 252A; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN TYROSINE KINASE A;

APOPTOSIS; BRAIN DISEASE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MECHANICS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW;

EID: 27744490957     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-005-0018-0     Document Type: Review

References (52)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, et al.: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995, 15:961-973.
2. Pang Z, Geddes JW: Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J Neurosci 1997, 17:3064-3073.
3. Dudek H, Datta SR, Franke TF, Birnbaum MJ, et al.: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997, 275:661-665.
4. Saito A, Hayashi T, Okuno S, et al.: Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J Neurosci 2003, 23:1710-1718.
5. Saito A, Narasimhan P, Hayashi T, et al.: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. J Neurosci 2004, 24:1584-1593.
6. Snider WD: Functions of the neurotrophins during development: what the knockouts are teaching us. Cell 1994, 77:627-638.
7. Chen KS, Nishimura MC, Armanini MP, et al.: Distribution of a single alle of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficit. J Neurosci 1997, 17:7288-7296.
8. Martinez A, Alcantara S, Borrell V, et al.: TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J Neurosci 1998, 18:7336-7350.
9. Tammariello SP, Quinn MT, Estus S: NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-derived sympathetic neurons. J Neurosci 2000, 20:1-5.
10. Han BH, Holtzman DM: BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 2000, 20:5775-5781.
11. Kirkland RA, Windelborn JA, Kasprzak JM, Franklin JL: A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J Neurosci 2002, 22:6480-6490.
12. Boulton TG, Nye SH, Robbins DJ, et al.: ERKs: a family of protein-serine/threonine kinase that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991, 65:663-675.
13. Segal RA, Greenberg ME: Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 1996, 19:463-489.
14. Sgambato V, Vanhoutte P, Pages C, et al.: In vivo expression and regulation of Elk-1, a target of the extracellular signal-regulated kinase signaling pathway, in the adult rat brain. J Neurosci 1998, 18:214-226.
15. Frodin M, Gammeltoft S: Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 1999, 151:65-77.
16. Tan Y, Ruan H, Demeter MR, Comb MJ: p90 (RSK) blocks bad-mediated cell death via a protein C-dependent pathway. J Biol Chem 1999, 274:34859-34867.
17. Zha J, Harada H, Yang E, et al.: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-XL. Cell 1996, 87:619-628.
18. Datta SR, Dudek H, Tao X, et al.: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
19. Cardone MH, Roy N, Stennicke HR, et al.: Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
20. Brunet A, Bonni A, Zigmond MJ, et al.: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868.
21. Vemuri GS, McMorris FA: Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development 1996, 122:2529-2537.
22. D'Mello SR, Borodezt K, Soltoff SP: Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of P13-kinase in IGF-1 signaling. J Neurosci 1997, 17:1548-1560.
23. Miller TM, Tansey MG, Johnson Jr EM, Creedon DJ: Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin- like growth factor I-mediated survival of cerebellar granule cells. J Biol Chem 1997, 272:9847-9853.
24. Dolcet X, Egea J, Soler R, et al.: Activation of the phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate neurotrophic factor-induced motoneuron survival. J Neurochem 1999, 73:521-531.
25. Meyer-Franke A, Wilkinson GA, Kruttgen A, et al.: Depolarization and cAMP elevation rapidly recruit trkB to the plasma membrane of CNS neurons. Neuron 1998, 21:681-693.
26. Bonni A, Brunet A, West AE, et al.: Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent machanisms. Science 1999, 286:1358-1365.
27. Cheng Y, Gidday JM, Yan Q, et al.: Marked age-dependent neuroprotection by BDNFagainst neonatal hypoxic-ischemic brain injury. Ann Neurol 1997, 41:521-529.
28. Han BH, D'Costa A, Black SA, et al.: BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiol Dis 2000, 7:38-53.
29. Barbacid M: The Trk family of neurotrophin receptors. J Neurobiol 1994, 25:1386-1403.
30. Kaplan DR, Martin-Zenca D, Parada LF: Tyrosine phosphorylation and tyrosin kinase activity of the trk proto-oncogene product induced by NGF. Nature 1991, 350:158-160.
31. Yao R, Cooper GM: Recruitment for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995, 267:2003-2006.
32. Crowder RJ, Freeman RS: Phosphatidylinositol 3-kinase and AKT protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 1998, 18:2933-2943.
33. Chan PH: Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001, 21:2-14.
34. Chan PH: Future targets and cascades for neuroprotective strategies. Stroke 2004, 35:2748-2750.
35. Chan PH: Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia. Neurochem Res 2004, 29:1943-1949.
36. Leist M, Kuhnle S, Single B, Nicotera P: Difference between apoptotic and necrotic cell death by means of the BM cell death detection ELIZA or annexin V staining. Biochemica 1998, 2:25-28.
37. Ernfors P, Ibanez CF, Ebendal T, et al.: Molecular cloning ad neurotrophic activities of a protein with structural similarties to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A 1990, 87:5454-5458.
38. Roback JD, Marsh HN, Downen M, et al.: BDNF-activated signal transduction in rat cortical glial cells. Eur J Neurosci 1995, 7:849-862.
39. Schäbitz WR, Schwab S, Spranger M, Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997, 17:500-506.
40. Sendtner M, Holtmann B, Kolbeck R, et al.: Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 1992, 360:757-759.
41. Tsukahara T, Yonekawa Y, Tanaka K, et al.: The role of BDNF in transient forebrain ischemia in the rat brain. Neurosurgery 1994, 34:323-330.
42. Kokaia Z, Zhao Q, Kokaia M, et al.: Regulation of BDNF gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 1995, 136:73-88.
43. Schäbitz WR, Sommer C, Zoder W, et al.: Intravenous brain-derived neurotrofic factor reduces infarct size ad counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 2000, 31:2212-2217.
44. Buchan AM, Williams L, Bruederlin B: Nerve growth factor: pretreatment ameliorates ischemic hippocampal neuronal injury [abstract]. Stroke 1990, 21:177.
45. Shigeno T, Mima T, Takakura K, et al.: Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J Neurosci 1991, 11:2914-2919.
46. Yamamoto S, Yoshimine T, Fujita T, et al.: Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayed neuronal death in gerbils. Neurosci Lett 1992, 141:161-165.
47. Zhang Y, Tatsuno T, Carney JM, Mattson MP: Basic FGF, NGF, and IGFs protect hippocampal and cortical nurons against iron-induced degeneration. J Cereb Blood Flow Metab 1993, 13:378-388.
48. Chao MV, Hempstead BL: p75 and TrkA: a two-receptor system. Trends Neurosci 1995, 18:321-326.
49. Yan C, Liang Y, Nylander KD, Schor NF: TrkA as a life and death receptor: receptor dose as a mediator of function. Cancer Res 2002, 62:4867-4875.
50. Casaccia-Bonnefil F, Carter BD, Dobrowsky RF, Chao MV: Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 1996, 383:716-719.
51. Beg AA, Baltimore D: An essential role for NF-kB in preventing TNF-a-induced cell death. Science 1996, 274:782-784.
52. Nagata S: Apoptosis by death factor. Cell 1997, 88:355-365.