Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs

International Immunology

Volumn 17, Issue 11, 2005, Pages 1495-1503

  Roundy, Kirstin M ^a   Spangrude, Gerald ^a   Weis, Janis J ^a   Weis, John H ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

B cells; Interferon; Marrow; Microphthalmic; Mouse; RANK RANKL

Indexed keywords

BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; BONE MARROW CELL; CELL MATURATION; CONGENITAL BONE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE OVEREXPRESSION; GENOTYPE; HEMATOPOIETIC STEM CELL; HYPOTHESIS; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; MAST CELL; MELANOCYTE; MOUSE STRAIN; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROLYMPHOCYTE; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANTIGENS, CD45; B-LYMPHOCYTES; BONE MARROW CELLS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; INTERFERON-BETA; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MICROPHTHALMOS; OSTEOPETROSIS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION;

EID: 27744436332     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh327     Document Type: Article

References (37)

1. Hodgkinson, C. A., Moore, K. J., Nakayama, A. et al. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395.
2. Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. and Ostrowski, M. C. 2002. The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts. J. Leukoc. Biol. 71:295.
3. Hemesath, T. J., Steingrimsson, E., McGill, G. et al. 1994. Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev. 8:2770.
4. Moore, K. J. 1995. Insight into the microphthalmia gene. Trends Genet. 11:442.
5. Roundy, K., Kollhoff, A., Eichwald, E. J., Weis, J. J. and Weis, J. H. 1999. Microphthalmic mice display a B cell deficiency similar to that seen for mast and NK cells. J Immunol. 163:6671.
6. Tagaya, H., Kunisada, T., Yamazaki, H. et al. 2000. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95:3363.
7. Roundy, K., Smith, R., Weis, J. J. and Weis, J. H. 2003 Overexpression of RANKL implicates IFN-beta-mediated elimination of B-cell precursors in the osteopetrotic bone of microphthalmic mice. J. Bone Miner. Res. 18:278.
8. Theill, L. E., Boyle, W. J. and Penninger, J. M. 2002. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20:795.
9. Lange, U., Saitou, M., Western, P., Barton, S. and Surani, M. 2003. The Fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev. Biol. 3:1.
10. Dutt, P., Wang, J. F. and Groopman, J. E. 1998. Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: A potential mechanism for cooperative induction of chemotaxis. J. Immunol. 161:3652.
11. Ma, Q., Jones, D. and Springer, T. A. 1999. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 10:463.
12. Ansel, K. M., Ngo, V. N., Hyman, P. L. et al. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406:309.
13. Legler, D. F., Loetscher, M., Roos, R. S., Clark-Lewis, I., Baggiolini, M. and Moser, B. 1998. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187:655.
14. Anderson, D. M., Maraskovsky, E., Billingsley, W. L. et al. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175
15. Wong, B. R., Josien, R., Lee, S. Y. et al. 1997. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186:2075.
16. Lacey, D. L., Timms, E., Tan, H. L. et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165.
17. Yasuda, H., Shima, N., Nakagawa, N. et al. 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl Acad. Sci. USA 95:3597.
18. Nakagawa, N., Kinosaki, M., Yamaguchi, K. et al. 1998. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253:395.
19. Hsu, H., Lacey, D. L., Dunstan, C. R. et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl Acad. Sci. USA 96:3540.
20. Takayanagi, H., Kim, S., Matsuo, K. et al. 2002. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416:744.
21. Biron, C. A. 2001. Interferons alpha and beta as immune regulators - a new look. Immunity 14:661.
22. Wang, J., Lin, Q., Langston, H. and Cooper, M. D. 1995. Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells. Immunity 3:475.
23. Lin, Q., Dong, C. and Cooper, M. D. 1998. Impairment of T and B cell development by treatment with a type I interferon. J. Exp. Med. 187:79.
24. Muller, U., Steinhoff, U., Reis, L. F. et al. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918.
25. Tan, S. S. and Weis, J. H. 1992. Development of a sensitive reverse transcriptase PCR assay, RT-RPCR, utilizing rapid cycle times. Genome Res. 2:137.
26. Zabel, M. D., Weis, J. J. and Weis, J. H. 1999. Lymphoid transcription of the murine CD21 gene is positively regulated by histone acetylation. J. Immunol. 163:2697.
27. Takayanagi, H., Kim, S. and Taniguchi, T. 2002. Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res. 4(Suppl. 3):S227.
28. Vasconcellos, R., Braun, D., Coutinho, A. and Demengeot, J. 1999. Type I IFN sets the stringency of B cell repertoire selection in the bone marrow. Int. Immunol. 11:279.
29. Gongora, R., Stephan, R. P., Zhang, Z. and Cooper, M. D. 2001. An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. Immunity 14:727.
30. Aoki, K., Shimoda, K., Oritani, K. et al. 2003. Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx. Exp. Hematol. 31:1317.
31. Oritani, K., Medina, K. L., Tomiyama, Y. et al. 2000. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat. Med. 6:659.
32. Kouro, T., Medina, K. L., Oritani, K. and Kincade, P. W. 2001. Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators. Blood 97:2708.
33. Hwang, S. Y., Hertzog, P. J., Holland, K. A. et al. 1995. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc. Natl Acad. Sci. USA 92:11284.
34. Simonet, W. S., Lacey, D. L., Dunstan, C. R. et al. 1997. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309.
35. Tsuda, E., Goto, M., Mochizuki, S. et al. 1997. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun. 234:137.
36. Yasuda, H., Shima, N., Nakagawa, N. et al. 1998. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139:1329.
37. Bosio, E., Cluning, C. L. and Beilharz, M. W. 2001. Low-dose orally administered type I interferon reduces splenic B cell numbers in mice. J Interferon Cytokine Res. 21:721.