Overexpression of RANKL implicates IFN-β-mediated elimination of B-cell precursors in the osteopetrotic bone of microphthalmic mice

Journal of Bone and Mineral Research

Volumn 18, Issue 2, 2003, Pages 278-288

  Roundy, K ^a   Smith, R ^a   Weis, J J ^a   Weis, J H ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

B lymphocyte; Microphthalmic; Osteoclast; Osteopetrotic; RANKL

Indexed keywords

BETA INTERFERON; CHEMOKINE; LYMPHOTACTIN; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR;

ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; BONE MARROW CELL; CELL MATURATION; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; MICROPHTHALMIA; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; STEM CELL; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BONE MARROW CELLS; CARRIER PROTEINS; FEMUR; GENE EXPRESSION PROFILING; GENOTYPE; INTERFERON-BETA; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICROPHTHALMOS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037302078     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.2.278     Document Type: Article

References (54)

1. Moore KJ 1995 Insight into the microphthalmia gene. Trends Genet 11:442-448.
2. Hemesath TJ, Steingrimsson E, McGill G, Hansen MJ, Vaught J, Hodgkinson CA, Arnheiter H, Copeland NG, Jenkins NA, Fisher DE 1994 Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev 8:2770-2780.
3. Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA, Arnheiter H 1993 Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395-404.
4. Roundy K, Kollhoff A, Eichwald EJ, Weis JJ, Weis JH 1999 Microphthalmic mice display a B-cell deficiency similar to that seen for mast and NK cells. J Immunol 163:6671-6678.
5. Reddi AH 1997 Bone morphogenesis and modeling: Soluble signals sculpt osteosomes in the solid state. Cell 89:159-161.
6. Stechschulte DJ, Sharma R, Dileepan KN, Simpson KM, Aggarwal N, Clancy J Jr, Jilka RL 1987 Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57B1/6J mice. J Cell Physiol 132:565-570.
7. Luchin A, Purdom G, Murphy K, Clark MY, Angel N, Cassady AI, Hume DA, Ostrowski MC 2000 The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts. J Bone Miner Res 15:451-460.
8. Walker DG 1975 Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science 190:784-785.
9. Walker DG 1973 Osteopetrosis cured by temporary parabiosis. Science 180:875.
10. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
11. Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, Choi Y 1997 TRANCE (tumor necrosis factor [TNF]-related activationinduced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186:2075-2080.
12. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L 1997 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-179.
13. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM 1999 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323.
14. Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J 1999 RANK is essential for osteoclast and lymph node development. Genes Dev 13:2412-2424.
15. Tagaya H, Kunisada T, Yamazaki H, Yamane T, Tokuhisa T, Wagner EF, Sudo T, Shultz LD, Hayashi SI 2000 Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95:3363-3370.
16. Aksan I, Goding CR 1998 Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol Cell Biol 18:6930-6938.
17. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
18. Tan SS, Weis JH 1992 Development of a sensitive reverse transcriptase PCR assay. RT-RPCR, utilizing rapid cycle times. Genome Res 2:137-143.
19. Chen Y, Garrison S, Weis JJ, Weis JH 1998 Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow. J Biol Chem 273:8711-8718.
20. Liang P, Pardee AB 1992 Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257:967-971.
21. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R 1995 Lymphopenia in interleukin (IL)-7 genedeleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526.
22. Ogawa M, Nishikawa S, Yoshinaga K, Hayashi S, Kunisada T, Nakao J, Kina T, Sudo T, Kodama H 1993 Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo. Development 117:1089-1098.
23. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shanafelt A, Muench M, Kelner G, Namikawa R, Rennick D, M. R, Zlotnik A, Rosnet O, Dubreuil P, Birnbaum D, Lee F 1994 Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of hematopoietic stem cells and is encoded by variant RNAs. Nature 368:643-648.
24. Lyman SD 1998 Biologic effects and potential clinical applications of Flt3 ligand. Curr Opin Hematol 5:192-196.
25. Yu H, Fehniger TA, Fuchshuber P, Thiel KS, Vivier E, Carson WE, Caligiuri MA 1998 Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15. Blood 92:3647-3657.
26. Nagasawa T 2000 A chemokine. SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis. Int J Hematol 72:408-411.
27. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA 1998 Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95:9448-9453.
28. Dutt P, Wang JF, Groopman JE 1998 Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: A potential mechanism for cooperative induction of chemotaxis. J Immunol 161:3652-3658.
29. Bachmann MF, Wong BR, Josien R, Steinman RM, Oxenius A, Choi Y 1999 TRANCE, a tumor necrosis factor family member critical for CD40 ligand- independent T helper cell activation. J Exp Med 189:1025-1031.
30. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Program AE. Boyle WJ 1997 Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
31. Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K 1997 Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234:137-142.
32. Fuller K, Wong B, Fox S, Choi Y, Chambers TJ 1998 TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 188:997-1001.
33. Ansel KM, Ngo VN, Hyman PL, Luther SA, Forster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG 2000 A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406:309-314.
34. Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B 1998 B-cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187:655-660.
35. Liang P, Averboukh L, Pardee AB 1993 Distribution and cloning of eukaryotic mRNAs by means of differential display: Refinements and optimization. Nucleic Acid Res 21:3269-3275.
36. Liang P, Zhu W, Zhang X, Guo Z, O'Connell RP, Averboukh L, Wang F, Pardee AB 1994 Differential display using one-base anchored oligo-dT primers. Nucleic Acid Res 22:5763-5764.
37. Schwarz DA, Katayama CD, Hedrick SM 1998 Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity 9:657-668.
38. Perou CM, Leslie JD, Green W, Li L, Ward DM, Kaplan J 1997 The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. J Biol Chem 272:29790-29794.
39. Lemer UH, Johansson L, Ranjso M, Rosenquist JB, Reinholt FP, Grubb A 1997 Cystatin C, and inhibitor of bone resorption produced by osteoblasts. Acta Physiol Scand 161:81-92.
40. Huh CG, Hakansson K, Nathanson CM, Thorgeirsson UP, Jonsson N, Grubb A, Abrahamson M, Karlsson S 1999 Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene. Mol Pathol 52:332-340.
41. McGarry RC, Walker R, Roder JC 1984 The cooperative effect of the satin and beige mutations in the suppression of NK and CTL activities in mice. Immunogenetics 20:527-534.
42. Dakour J, Li H, Morrish DW 1997 PL48: A novel gene associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. Gene 185:153-157.
43. Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D, Huez GA, Wathelet MG 1995 Expression cloning of an interferoninducible 17-kDa membrane protein implicated in the control of cell growth. J Biol Chem 270:23860-23866.
44. Lewin AR, Reid LE. McMahon M, Stark GR, Kerr IM 1991 Molecular analysis of a human interferon-inducible gene family. Eur J Biochem 199:417-423.
45. Clave E, Carosella ED, Gluckman E, Socie G 1997 Radiation-ehanced expression of interferon-inducible genes in the KG1a primitive hematopoietic cell line. Leukemia 11:114-119.
46. Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, Wagner EF, Taniguchi T 2002 RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416:744-749.
47. Meyer M, Erdel M, Duba HC, Werner ER, Wemer-Felmayer G 2000 Cloning, genomic sequence, and chromosome mapping of Scyb11, the murine homologue of SCYB11 (alias betaR1/H174/ SCYB9B/I-TAC/IP-9/CXCL11). Cytogenet Cell Genet 88:278-282.
48. Wong BR, Josien R, Choi Y 1999 TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J Leukoc Biol 65:715-724.
49. Kincade PW 1994 B lymphopoiesis: Global factors, local control. Proc Natl Acad Sci USA 91:2888-2889.
50. Biron CA 2001 Interferons alpha and beta as immune regulators - a new look. Immunity 14:661-664.
51. Wang J, Lin Q, Langston H, Cooper MD 1995 Resident bone marrow macrophages produce type I interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells. Immunity 3:475-484.
52. Lin Q, Dong C, Cooper MD 1998 Impairment of T and B-cell development by treatment with a type I interferon. J Exp Med 187:79-87.
53. Gongora R, Stephan RP, Zhang Z, Cooper MD 2001 An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. Immunity 14:727-737.
54. Smith TJ, Ducharme LA, Weis JH 1994 Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3. Eur J Immunol 24:822-826.