Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel

Biophysical Journal

Volumn 89, Issue 5, 2005, Pages 3079-3092

  Sheng, Jian Zhong ^a   Weljie, Aalim ^a   Sy, Lusia ^a   Ling, Shizhang ^a   Vogel, Hans J ^a   Braun, Andrew P ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; MAGNESIUM ION;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; ENERGY; HUMAN; HUMAN CELL; MOLECULAR MODEL; MUTANT; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STEADY STATE;

BACTERIA (MICROORGANISMS);

EID: 27744434833     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.063610     Document Type: Article

References (40)

1. Adelman, J. P., K.-Z. Shen, M. P. Kavanaugh, R. A. Warren, Y.-N. Wu, A. Lagrutta, C. T. Bond, and R. A. North. 1992. Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron. 9:209-216.
2. 2+ sensing. J. Gen. Physiol. 123:475-489.
3. 2+ sensitivity. J. Gen. Physiol. 120:173-189.
4. 2+-dependent activation. Proc. Natl. Acad. Sci. USA. 98:4776-4781.
5. + channel. J. Physiol. (Lond.). 533:681-695.
6. Bulter, A., S. Tsunoda, D. P. McCobb, A. Wei, and L. Salkoff. 1993. mSlo, a complex mouse gene encoding 'maxi' calcium-activated potassium channels. Science. 261:221-224.
7. Chattopadhyaya, R., W. E. Meador, A. R. Means, and F. A. Quiocho. 1992. Calmodulin structure refined at 1.7 Å resolution. J. Mol. Biol. 228:1177-1192.
8. 2+ sensitivity. J. Gen. Physiol. 116:411-432.
9. + channels. Biochemistry. 39:15612-15619.
10. + channels. J. Gen. Physiol. 109:647-673.
11. 2+ dependency. EMBO J. 16:2565-2575.
12. + channels. J. Physiol. (Lond.). 489:403-418.
13. Falke, J. J., S. K. Drake, A. L. Hazard, and O. B. Peersen. 1994. Molecular tuning of ion binding to calcium signaling proteins. Q. Rev. Biophys. 27:219-290.
14. Geiser, J. R., D. van Tuinen, S. E. Brockerhoff, M. M. Neff, and T. N. Davis. 1991. Can calmodulin function without binding calcium? Cell. 65:949-959.
15. Ca channel variants differentially expressed in rat brain tissues. Eur. J. Biochem. 267:910-918.
16. 2+. Biochemistry. 35:5856-5869.
17. + channel and demonstration of its presence in the human BK channel. Neuron. 29:593-601.
18. Linse, S., P. Brodin, C. Johansson, E. Thulin, T. Grundström, and S. Forśn. 1988. The role of protein surface charges in ion binding. Nature. 335:651-652.
19. Linse, S., and S. Forsén. 1995. Determinants that govern high-affinity calcium binding. In Advances in Second Messenger and Phosphoprotein Research. A. R. Means, editor. Raven Press, New York, NY. 89-151.
20. 9K. Biochemistry. 30:154-162.
21. Ca channels (rSlo) expressed in HEK 293 cells by N-methyl D-glucamine. Pflugers Arch. 436:810-812.
22. Magleby, K. L. 2003. Gating mechanism of BK (Slo1) channels: so near, yet so far. J. Gen. Physiol. 121:81-96.
23. Marsden, B. J., G. S. Shaw, and B. D. Sykes. 1990. Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments. Biochem. Cell Biol. 68:587-601.
24. Moncrief. N. D., R. H. Kretsinger, and M. Goodman. 1990. Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences. J. Mol. Evol. 30:522-562.
25. 2+. Proc. Natl. Acad. Sci. USA. 99:11441-11446.
26. Pallanck, L., and B. Ganetzky. 1994. Cloning and characterization of human and mouse homologs of the Drosophilia calcium-activated potassium channel gene, slowpoke. Hum. Mol. Genet. 3:1239-1243.
27. 2+ channels. Biophys. J. 78: 1906-1920.
28. Putkey, J. A., H. L. Sweeney, and S. T. Campbell. 1989. Site-directed mutagenesis of the trigger calcium-binding sites in cardiac troponin C. J. Biol. Chem. 264:12370-12378.
29. + channels described by a two-tiered allosteric gating mechanism. J. Gen. Physiol. 116:75-99.
30. Salinas, M., R. Reyes, F. Lesage, M. Fosset, C. Heurteaux, G. Romey, and M. Lazdunski. 1999. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J. Biol. Chem. 274:11751-11760.
31. Schreiber, M., and L. Salkoff. 1997. A novel calcium-sensing domain in the BK channel. Biophys. J. 73:1355-1363.
32. Schreiber, M., A. Yuan, and L. Salkoff. 1999. Transplantable sites confer calcium sensitivity to BK channels. Nat. Neurosci. 2:416-421.
33. + channels. J. Gen. Physiol. 118:589-605.
34. Shi, J., G. Krishnamoorthy, Y. Yang, L. Hu, N. Chaturvedi, D. Harilal, and J. Cui. 2002. Mechanism of magnesium activation of calcium-activated potassium channels. Nature. 418:876-880.
35. Ca channels determined by a separable domain. Neuron. 13:671-681.
36. Weljie, A. M., T. E. Clarke, A. H. Juffer, A. C. Harmon, and H. J. Vogel. 2000. Comparative modeling studies of the calmodulin-like domain of calcium-dependent protein kinase from soybean. Proteins. 39:343-357.
37. Wingo, T. L., V. N. Shah, M. E. Anderson, T. P. Lybrand, J. W. Chazin, and J. R. Balser. 2004. An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat. Struct. Mol. Biol. 11:219-225.
38. Xia, X.-M., X. Zeng, and C. J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
39. Zeng, X.-H., X.-M. Xia, and C. Lingle. 2005. Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites. J. Gen. Physiol. 125:273-286.
40. 2+ through a nonselective, low affinity divalent cation site. J. Gen. Physiol. 118:607-635.