Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity

Organic and Biomolecular Chemistry

Volumn 3, Issue 20, 2005, Pages 3678-3685

  Lee, Jean ^a   Chubb, Anthony J ^a   Moman, Edelmiro ^a   McLoughlin, Brian M ^a   Sharkey, Caroline T ^a   Kelly, John G ^a   Nolan, Kevin B ^a   Devocelle, Marc ^a   Fitzgerald, Desmond J ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYME INHIBITION; SYNTHESIS (CHEMICAL); TISSUE;

ASPIRIN; CYCLOOXYGENASE (COX); IN VITRO ACTIVITY; PEROXIDASE (POX);

ANTIBIOTICS;

ANTHRANILIC ACID DERIVATIVE; ANTHRANILIC HYDROXAMIC ACID; ENZYME INHIBITOR; HYDROXAMIC ACID; ISOENZYME; PEROXIDASE; PROSTAGLANDIN SYNTHASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTHRANILIC ACIDS; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROXAMIC ACIDS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEROXIDASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744433968     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b505525c     Document Type: Article

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