A novel family of hydroxamate-based acylating inhibitors of cyclooxygenase

Molecular Pharmacology

Volumn 63, Issue 2, 2003, Pages 450-455

  Dooley, C M ^a   Devocelle, M ^a   McLoughlin, B ^a   Nolan, K B ^a   Fitzgerald, D J ^a   Sharkey, C T ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL O,N DIACETYLBENZOHYDROXAMIC ACID; ACETYLSALICYLIC ACID; ALANINE; ARACHIDONIC ACID; CYCLOOXYGENASE 1 INHIBITOR; GLUTAMINE; HYDROXAMIC ACID DERIVATIVE; N METHYL O,O DIACETYLSALICYLHYDROXAMIC ACID; O ACETYLSALICYLHYDROXAMIC ACID; SERINE; TRIACETYLSALICYLHYDROXAMIC ACID; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR INTERACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; THROMBOCYTE AGGREGATION;

ACETYLATION; ANIMALS; ARGININE; BINDING SITES; COS CELLS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; ISOENZYMES; MEMBRANE PROTEINS; PLATELET AGGREGATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SALICYLAMIDES; SERINE;

EID: 0037308905     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.2.450     Document Type: Article

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