Surfing the piperazine core of tricyclic farnesyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 24, 2005, Pages 5537-5543

  Rokosz, Laura L ^a   Huang, Chia Yu ^a   Reader, John C ^a   Stauffer, Tara M ^a   Chelsky, Daniel ^a   Sigal, Nolan H ^a   Ganguly, Ashit K ^b   Baldwin, John J ^a  

^a PHARMACOPEIA INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anti cancer; Combinatorial chemistry; ECLiPS ; Farnesyltransferase inhibitors; High throughput screening; Scintillation proximity assay (SPA)

Indexed keywords

PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; COMBINATORIAL LIBRARY; DRUG SCREENING; DRUG SYNTHESIS; SCINTILLATION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; IMIDAZOLES; KINETICS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27644597168     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.074     Document Type: Article

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