Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig

Platelets

Volumn 16, Issue 7, 2005, Pages 408-414

  Lipcsey, Miklós ^a   Larsson, Anders ^a   Olovsson, Matts ^a   Sjölin, Jan ^a   Eriksson, Mats B ^a,b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b Sanofi Aventis   (Sweden)

Author keywords

Clopidogrel; Creatinine clearance; Fibrin; Immunohistochemistry; Platelet; Septic shock

Indexed keywords

ANTIBODY; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; CREATININE; ENDOTOXIN; FIBRIN; FIBRINOGEN; FLUORESCEIN ISOTHIOCYANATE; INTERLEUKIN 6; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANESTHESIA; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; ENDOTOXEMIA; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMODYNAMICS; HEMOSTASIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY BIOPSY; KIDNEY FUNCTION; MALE; MICROSCOPY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; SWINE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT;

ANIMALS; BLOOD PLATELETS; BLOOD PRESSURE; CREATININE; ENDOTOXINS; FEMALE; HEMOSTASIS; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; OXYGEN; PLATELET AGGREGATION INHIBITORS; RANDOM ALLOCATION; SWINE; TICLOPIDINE; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 27644580754     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100500163168     Document Type: Article

References (35)

1. Iqbal O, Messmore H, Fareed J, Ahmad S, Hoppensteadt D, Shadid H, et al. Antithrombotic agents in the treatment of severe sepsis. Expert Opin Emerging Drugs 2002;7:111-139.
2. Bredengard C, Nordfang O, Wildgoose P, Svendsen O, Hedner U, Diness V. The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits. Blood Coagulation Fibrinolysis 1993;4:699-706.
3. Yamazaki M, Asakura H, Aoshima K, Saito M, Jokaji H, Uotani C, et al. Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats. Thromb Haemost 1994;72:392-396.
4. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. New Engl J Med 2001;344:699-709.
5. Eriksson M, Larsson A, Saldeen T, Mattsson C. Melagatran, a low molecular weight thrombin inhibitor, counteracts endotoxin-induced haemodynamic and renal dysfunctions in the pig. Thromb Haemost 1998;80:1022-1026.
6. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001;413:74-78.
7. Brass LF. Thrombin and platelet activation. Chest 2003;124:18S-25S.
8. Dorsam RT, Kunapuli SP. Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004;113:340-345.
9. Gachet C, Savi P, Ohlmann P, Maffrand JP, Jakobs KH, Cazenave JP. ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes-An effect selectively blocked by the thienopyridine clopidogrel. Thromb Haemost 1992;68:79-83.
10. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001;409:202-207.
11. Merrien D. Particularites des maladies infectieuses chez le sujet age. Presse Med 2002;31:1517-1520.
12. Larsson A, Lundahl T, Eriksson M, Lundkvist K, Lindahl T. Endotoxin induced platelet microvesicle formation measured by flow cytometry. Platelets 1996;7:153-158.
13. Roussi J, Berge N, Bal dit Sollier C, Bonneau M, Andre P, Pignaud G, et al. Clopidogrel-induced qualitative changes in thrombus formation correlate with stent patency in injured pig cervical arteries. Thromb Res 2002;105:209-216.
14. Makkar RR, Eigler NL, Kaul S, Frimerman A, Nakamura M, Shah PK, et al. Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis. Eur Heart J 1998;19:1538-1546.
15. Bostwick JS, Costanzo S, Byan L, Luo Y, Natarajan C, Bilder G. Clopidogrel but not ticlopidine produces an antiplatelet effect in the Yucatan minipig. Thromb Haemost 2000;84:928.
16. Fox SC, Sasae R, Janson S, May JA, Heptinstall S. Quantitation of platelet aggregation and microaggregate formation in whole blood by flow cytometry. Platelets 2004;15:85-93.
17. Larsson A, Eriksson M, Lindahl TL. Studies of fibrinogen binding to porcine platelets by flow cytometry: A method for studies of porcine platelet activation. Platelets 2002;13:153-157.
18. Modig J. Adult respiratory distress syndrome. Comp Pathol Bull 1989;21:2-4.
19. Eriksson M, Nelson D, Nordgren A, Larsson A. Increased platelet microvesicle formation is associated with mortality in a porcine model of endotoxemia. Acta Anaesthesiol Scand 1998;42:551-557.
20. Santak B, Radermacher P, Adler J, Iber T, Rieger KM, Wachter U, et al. Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs. Bri J Pharmacol 1998;124:1689-1697.
21. Carlstedt F, Eriksson M, Kiiski R, Larsson A, Lind L. Hypocalcemia during porcine endotoxemic shock: Effects of calcium administration. Crit Care Med 2000;28:2909-2914.
22. Mutschler DK, Eriksson MB, Wikstrom BG, Lind L, Larsson A, Bergren-Kiiski R, et al. Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia. Crit Care Med 2003;31:1780-1785.
23. Clark CA, Harman EM. Hemodynamic monitoring: Pulmonary artery catheters. In: Civetta JM, Taylor RW, Kirby RR, editors. Critical care. Philadelphia, PA: JB Lippincott Co; 1988. p 293-302.
24. Larsson A, Eriksson M, Lundahl T, Lundkvist K, Lindahl T. Impaired platelet function in endotoxemic pigs analyzed by flow cytometry. Platelets 1998;9:115-119.
25. Moller B, Lindblom B, Olovsson M. Expression of the vascular endothelial growth factors B and C and their receptors in human endometrium during the menstrual cycle. Acta Obstet Gynecol Scand 2002;81:817-824.
26. Bergmann M, Gornikiewicz A, Tamandl D, Exner R, Roth E, Fugger R, et al. Continuous therapeutic epinephrine but not norepinephrine prolongs splanchnic IL-6 production in porcine endotoxic shock. Shock 2003;20:575-581.
27. Allen DG, Riviere JE, Monteiro-Riviere NA. Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes. Toxicol Lett 2001;119:209-217.
28. Hermida J, Montes R, Paramo JA, Rocha E. Endotoxin-induced disseminated intravascular coagulation in rabbits: Effect of recombinant hirudin on hemostatic parameters, fibrin deposits, and mortality. J Lab Clin Med 1998;131:77-83.
29. Yang LH, Hoppensteadt D, Fareed J. Modulation of vasoconstriction by clopidogrel and ticlopidine. Thromb Res 1998;92:83-89.
30. Pernow J, Hemsen A, Hallen A, Lundberg JM. Release of endothelin-like immunoreactivity in relation to neuropeptide Y and catecholamines during endotoxin shock and asphyxia in the pig. Acta Physiol Scand 1990;140:311-322.
31. Keeler R. Effects of methysergide or phenoxybenzamine on the renal and cardiovascular responses to endotoxin in rats. Circ Shock 1981;8:361-368.
32. Taylor FB, Coller BS, Chang AC, Peer G, Jordan R, Engellener W, et al. 7E3 F(ab')2, a monoclonal antibody to the platelet GPIIb/IIIa receptor, protects against microangiopathic hemolytic anemia and microvascular thrombotic renal failure in baboons treated with C4b binding protein and a sublethal infusion of Escherichia coli. Blood 1997;89:4078-4084.
33. Pu Q, Wiel E, Corseaux D, Bordet R, Azrin MA, Ezekowitz MD, et al. Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock. Crit Care Med 2001;29:1181-1188.
34. Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, et al. Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 2002;30:1288-1295.
35. Eriksson M, Basu S, Larsson A, Mattsson C, Eriksson O, Kiiski R, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs 2000;9:1129-1137.