Impaired platelet function in endotoxemic pigs analyzed by flow cytometry

Platelets

Volumn 9, Issue 2, 1998, Pages 115-119

  Larsson, A ^a   Eriksson, M ^a   Lundahl, T ^b   Lundkvist, K ^a   Lindahl, T ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; ESCHERICHIA COLI ENDOTOXIN; FIBRINOGEN; FLUORESCEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD OXYGEN TENSION; CELL STIMULATION; CONTROLLED STUDY; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTOXEMIA; ERYTHROCYTE COUNT; FEVER; FLOW CYTOMETRY; GRAM NEGATIVE BACTERIUM; HYPOTENSION; LEUKOCYTE COUNT; LEUKOPENIA; METABOLIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SHOCK; SWINE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA;

EID: 0031979644     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/09537109876898     Document Type: Article

References (18)

1. Freudenberg MA, Galanos C. Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action. Intern Rev Immunol 1990; 6: 207-21.
2. Mammen EF. Perspectives for the future. Intens Care Med 1993; 19: S29-34.
3. Lynn WA, Golenbock DT. Lipopolysaccharide antagonists. Immunol Today 1992; 13; 271-6.
4. Talan DA. Recent developments in our understanding of sepsis: evaluation of anti-endotoxin antibodies and biological response modifiers. Ann Emerg Med 1993; 22: 1871-90.
5. Stone R. Search for sepsis drugs goes on despite past failures. Science 1994; 264: 365-7.
6. Grabarek J, Her GR, Reinhold VN, Hawiger J. Endotoxic lipid A interaction with human platelets. Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. J Biol Chem 1990; 265: 8117-21.
7. Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombin activity. J Biol Chem 1988; 263: 18205-12.
8. Valone FH. Platelet-activating factor binding and metabolism during human platelet aggregation. Thromb Res 1988; 50: 103-12.
9. Modig J. Adult respiratory distress syndrome. Comn Path Bull 1989; 21: 2-4.
10. Larsson A, Lundahl T, Eriksson M, Lundkvist K, Lindahl TL. Detection of endotoxin-induced platelet microparticle formation by now cytometry. Platelets 1996; 7: 153-8.
11. Larsson A, Bålöw R-M, Lindahl TL, Forsberg P-O. Chicken IgG: utilizing the evolutionary advantage. Poultry Sci 1993; 72: 1807-12.
12. Lindahl TL, Festin R, Larsson A. Studies of fibrinogen binding to platelets by flow cytometry: an improved method for detection of platelet activation. Thromb Haemostas 1992; 68: 221-5.
13. Lindahl T, Larsson A. Clq binding to platelets induced by monoclonal antibodies and immune complexes - a flow cytometric analysis. Platelets 1993; 4: 73-7.
14. Young LS. Gram-negative sepsis. In: Mandell C, Douglas J, Bennett J, eds. Principles and Practice of Infectious Diseases. New York: Wiley Medical Books, 1979: 452-75.
15. Shattil SJ, Howie JA, Cunningham M, Brass LF. Changes in platelet membrane glycoprotein IIb/IIIa complex during platelet activation. J Biol Chem 1985; 260: 11107-14.
16. Nyström ML, Barradas MA, Jeremy JY, Mikhailidis DP. Platelet shape change in whole blood: differential effects of endotoxin. Thromb Haemostas 1994; 71: 646-50.
17. Salden HJM, Bas BM. Endotoxin binding to platelets in blood from patients with a sepsis syndrome. Clin Chem 1994; 40: 1575-9.
18. Grabarek J, Timmons S, Hawiger J. Modulation of human platelet protein kinase C by endotoxic lipid A. J Clin Invest 1988; 82: 964-71.