메뉴 건너뛰기




Volumn 124, Issue 8, 1998, Pages 1689-1697

Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs

Author keywords

Capillary haemoglobin O2 saturation; Endotoxin; Gluconeogenesis; Heparic glucose precursor uptake; Hepatic blood flow; Hepatic O2 exchange; Lactate pyruvate ratio; Remission spectrophotometry; Septic shock; Stable isotope infusion

Indexed keywords

ALANINE; ENDOTOXIN; GLUCOSE; GLYCEROL; HEMOGLOBIN; HETASTARCH; LACTIC ACID; OXYGEN; PYRUVIC ACID;

EID: 0031847810     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701998     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 0025201971 scopus 로고
    • Metabolic regulation of renal gluconeogenesis in response to sepsis in the rat
    • ARDAWI, M.S.M., KHOJA, S.M. & NEWSHOLME, E.A. (1990). Metabolic regulation of renal gluconeogenesis in response to sepsis in the rat. Clin. Sci. Colch., 79, 483-490.
    • (1990) Clin. Sci. Colch. , vol.79 , pp. 483-490
    • Ardawi, M.S.M.1    Khoja, S.M.2    Newsholme, E.A.3
  • 2
    • 0023815459 scopus 로고
    • Early impairment of oxidative metabolism and energy production in severe sepsis
    • ASTIZ, M., RACKOW, E.C., WEIL, M.H. & SCHUMER, W. (1988). Early impairment of oxidative metabolism and energy production in severe sepsis. Circ. Shock, 26, 311-320.
    • (1988) Circ. Shock , vol.26 , pp. 311-320
    • Astiz, M.1    Rackow, E.C.2    Weil, M.H.3    Schumer, W.4
  • 3
    • 0022644165 scopus 로고
    • Multiple organ failure syndrome. The gastrointestinal tract: The 'motor' of MOF
    • CARRICO, C.J., MEAKINS, J.L., MARSHALL, J.C., FRY, D. & MAIER, R.V. (1986). Multiple organ failure syndrome. The gastrointestinal tract: The 'motor' of MOF. Arch. Surg., 121, 196-208.
    • (1986) Arch. Surg. , vol.121 , pp. 196-208
    • Carrico, C.J.1    Meakins, J.L.2    Marshall, J.C.3    Fry, D.4    Maier, R.V.5
  • 5
    • 0040265633 scopus 로고
    • Pyruvat, Phosphoenolpyruvat und D-Glycerat-2-phosphat
    • edited by Bergmeyer, H.U., Weinheim, Verlag Chemie
    • CZOK, R. & LAMPRECHT, W. (1970). Pyruvat, Phosphoenolpyruvat und D-Glycerat-2-phosphat. In: Methoden der Enzymatischen Analyse Band II., edited by Bergmeyer, H.U., Weinheim, Verlag Chemie, p. 1407-1411.
    • (1970) Methoden der Enzymatischen Analyse , vol.2 , pp. 1407-1411
    • Czok, R.1    Lamprecht, W.2
  • 6
    • 0023205139 scopus 로고
    • Splanchnic and total body oxygen consumption differences in septic and injured patients
    • DAHN, M.S., LANGE, P., LOBDELL, K., HANS, B., JACOBS, L.A. & MITCHELL, R.A. (1987). Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery, 101, 69-80.
    • (1987) Surgery , vol.101 , pp. 69-80
    • Dahn, M.S.1    Lange, P.2    Lobdell, K.3    Hans, B.4    Jacobs, L.A.5    Mitchell, R.A.6
  • 9
    • 0027176655 scopus 로고
    • The gastrointestinal tract. The canary of the body?
    • DANTZKER, D.R. (1993). The gastrointestinal tract. The canary of the body? JAMA, 270, 1247-1248.
    • (1993) JAMA , vol.270 , pp. 1247-1248
    • Dantzker, D.R.1
  • 10
    • 0015356172 scopus 로고
    • Of pigs and men and research: A review of applications and analogies of the pig, sus scrofa, in human medical research
    • DOUGLAS, W. R. (1972). Of pigs and men and research: a review of applications and analogies of the pig, sus scrofa, in human medical research. Space Life Sci., 3, 226-234.
    • (1972) Space Life Sci. , vol.3 , pp. 226-234
    • Douglas, W.R.1
  • 11
    • 0023930822 scopus 로고
    • The theoretical bases of indirect calorimetry: A review
    • EERRANNINI, E. (1988). The theoretical bases of indirect calorimetry: A review. Metabolism, 37, 287-301.
    • (1988) Metabolism , vol.37 , pp. 287-301
    • Eerrannini, E.1
  • 12
    • 0016167507 scopus 로고
    • Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock
    • FILKINS, J.P. & CORNELL, R.P. (1974). Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock. Am. J. Physiol., 227, 778-781.
    • (1974) Am. J. Physiol. , vol.227 , pp. 778-781
    • Filkins, J.P.1    Cornell, R.P.2
  • 14
    • 0024367851 scopus 로고
    • The Erlangen micro-lightguide spectrophotometer EM-PHO I
    • FRANK, K. H., KESSLER, M., APPELBAUM, K. & DÜMMLER, W. (1989). The Erlangen micro-lightguide spectrophotometer EM-PHO I. Phys. Med. Biol., 34, 1883-1900.
    • (1989) Phys. Med. Biol. , vol.34 , pp. 1883-1900
    • Frank, K.H.1    Kessler, M.2    Appelbaum, K.3    Dümmler, W.4
  • 15
    • 0029164376 scopus 로고
    • Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious endotoxaemic rats
    • GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, T. (1995). Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious endotoxaemic rats. Br. J. Pharmacol., 116, 2005-2016.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2005-2016
    • Gardiner, S.M.1    Kemp, P.A.2    March, J.E.3    Bennett, T.4
  • 17
    • 0039523708 scopus 로고
    • Endotoxin dose. I. Hemodynamic, metabolic, and lethal consequences in Yucatan minipigs
    • HAND, M.S., FETTMAN, M.J., CHANDRASENA, L.G., CLEEK, J.L. & PHILLIPS, R.W. (1983a). Endotoxin dose. I. Hemodynamic, metabolic, and lethal consequences in Yucatan minipigs. Am. J. Physiol., 244, E385-E398.
    • (1983) Am. J. Physiol. , vol.244
    • Hand, M.S.1    Fettman, M.J.2    Chandrasena, L.G.3    Cleek, J.L.4    Phillips, R.W.5
  • 20
    • 7344228348 scopus 로고
    • SIRS: Is it a liver disease?
    • HAWKER, F. (1994). SIRS: Is it a liver disease?. Int. J. Intensive Care, 1, 113.
    • (1994) Int. J. Intensive Care , vol.1 , pp. 113
    • Hawker, F.1
  • 21
    • 0021322123 scopus 로고
    • Significance of mitochondrial enhancement in hepatic energy metabolism in relation to alterations in hemodynamics in septic pigs with severe peritonitis
    • HIRAI, F., AOYAMA, H. OHTOSHI, M., KAWASHIMA, S., OZAWA, K. & TOBE, T. (1984). Significance of mitochondrial enhancement in hepatic energy metabolism in relation to alterations in hemodynamics in septic pigs with severe peritonitis. Eur. Surg. Res., 16, 148-155.
    • (1984) Eur. Surg. Res. , vol.16 , pp. 148-155
    • Hirai, F.1    Aoyama, H.2    Ohtoshi, M.3    Kawashima, S.4    Ozawa, K.5    Tobe, T.6
  • 22
    • 0004644435 scopus 로고
    • L-(+)-Lactat
    • edited by Bergmeyer, H.U., Weinheim, Verlag Chemie
    • HOHORST, H.J. (1970). L-(+)-Lactat, In: Methoden der Enzymatischen Analyse Band II, edited by Bergmeyer, H.U., Weinheim, Verlag Chemie, p. 1425-1429.
    • (1970) Methoden der Enzymatischen Analyse , vol.2 , pp. 1425-1429
    • Hohorst, H.J.1
  • 23
    • 0026602489 scopus 로고
    • Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis
    • HOTCHKISS, R.S. & KARL, I.E. (1992). Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA, 267, 1503-1510.
    • (1992) JAMA , vol.267 , pp. 1503-1510
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 24
    • 0016705083 scopus 로고
    • Hepatic blood flow and oxygen consumption in starvation, sepsis and septic shock
    • IMAMURA, M. & CLOWES G.H.A. (1975). Hepatic blood flow and oxygen consumption in starvation, sepsis and septic shock. Surg. Gynecol. Obstet., 141, 27-34.
    • (1975) Surg. Gynecol. Obstet. , vol.141 , pp. 27-34
    • Imamura, M.1    Clowes, G.H.A.2
  • 26
    • 0026600946 scopus 로고
    • Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
    • JUNGAS, R.L., HALPERIN, M.L. & BROSNAN, J.T. (1992). Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. Physiol. Rev., 72, 419-448.
    • (1992) Physiol. Rev. , vol.72 , pp. 419-448
    • Jungas, R.L.1    Halperin, M.L.2    Brosnan, J.T.3
  • 27
    • 0022148042 scopus 로고
    • Glucose dyshomeostasis and cardiovascular failure in endotoxic dogs
    • KOBER, P.M., THOMAS, J.X. & FILKINS, J.P. (1985). Glucose dyshomeostasis and cardiovascular failure in endotoxic dogs. Am. J. Physiol., 249, R570-R577.
    • (1985) Am. J. Physiol. , vol.249
    • Kober, P.M.1    Thomas, J.X.2    Filkins, J.P.3
  • 28
    • 0028053865 scopus 로고
    • Microvascular perfusion is impaired in a rat model of normotensive sepsis
    • LAM, C., TYML, K., MARTIN, C. & SIBBALD, W. (1994). Microvascular perfusion is impaired in a rat model of normotensive sepsis. J. Clin. Invest., 94, 2077-2083.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2077-2083
    • Lam, C.1    Tyml, K.2    Martin, C.3    Sibbald, W.4
  • 29
    • 0021186824 scopus 로고
    • Carbohydrate dynamics in the hypermetabolic septic rat
    • LANG, C.H., BAGBY, G.J. & SPITZER, J.J. (1984). Carbohydrate dynamics in the hypermetabolic septic rat. Metabolism, 33, 959-963.
    • (1984) Metabolism , vol.33 , pp. 959-963
    • Lang, C.H.1    Bagby, G.J.2    Spitzer, J.J.3
  • 30
    • 0023258487 scopus 로고
    • Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion
    • LANG, C.H. & SPITZER, J.A. (1987). Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion. Metabolism, 36, 469-474.
    • (1987) Metabolism , vol.36 , pp. 469-474
    • Lang, C.H.1    Spitzer, J.A.2
  • 33
    • 0026518237 scopus 로고
    • Splanchnic and total body oxygen consumption in experimental fecal peritonitis in pigs: Effects of dextran and iloprost
    • RASMUSSEN, I., ARVIDSSON, D., ZAK, A. & HAGLUND, U. (1992). Splanchnic and total body oxygen consumption in experimental fecal peritonitis in pigs: effects of dextran and iloprost. Circ. Shock, 36, 299-306.
    • (1992) Circ. Shock , vol.36 , pp. 299-306
    • Rasmussen, I.1    Arvidsson, D.2    Zak, A.3    Haglund, U.4
  • 34
    • 0030957475 scopus 로고    scopus 로고
    • Effects of a dobutamine-induced increase in splanchnic blood flow on hepatic metabolic activity in patients with septic shock
    • REINELT, H., RADERMACHER, P., FISCHER, G., GEISSER, W., WACHTER, U., WIEDECK, H., GEORGIEFF, M. & VOGT, J. (1997). Effects of a dobutamine-induced increase in splanchnic blood flow on hepatic metabolic activity in patients with septic shock. Anesthesiology, 86, 818-824.
    • (1997) Anesthesiology , vol.86 , pp. 818-824
    • Reinelt, H.1    Radermacher, P.2    Fischer, G.3    Geisser, W.4    Wachter, U.5    Wiedeck, H.6    Georgieff, M.7    Vogt, J.8
  • 37
    • 0021369066 scopus 로고
    • A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans
    • SHAW, J.H.F. & WOLFE, R.R. (1984). A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans. Surgery, 95, 553-561.
    • (1984) Surgery , vol.95 , pp. 553-561
    • Shaw, J.H.F.1    Wolfe, R.R.2
  • 38
    • 0021800976 scopus 로고
    • Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers
    • SHAW, J.H.F., KLEIN, S. & WOLFE, R.R. (1985). Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers. Surgery, 97, 557-568.
    • (1985) Surgery , vol.97 , pp. 557-568
    • Shaw, J.H.F.1    Klein, S.2    Wolfe, R.R.3
  • 39
  • 40
    • 0028144599 scopus 로고
    • Oxygen transport-dependent splanchnic metabolism in the sepsis syndrome
    • STEFFES, C.P., DAHN, M.S. & LANGE, M.P. (1994). Oxygen transport-dependent splanchnic metabolism in the sepsis syndrome. Arch. Surg., 129, 46-52.
    • (1994) Arch. Surg. , vol.129 , pp. 46-52
    • Steffes, C.P.1    Dahn, M.S.2    Lange, M.P.3
  • 41
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
    • STUMVOLL, M., CHINTALAPUDI, U., PERRIELLO, G., WELLE, S., GUTIERREZ, O. & GERICH, J. (1995). Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J. Clin. Invest., 96, 2528-2533.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3    Welle, S.4    Gutierrez, O.5    Gerich, J.6
  • 42
    • 0024423390 scopus 로고
    • Measurement of gas exchange in intensive care: Laboratory and clinical validation of a new device
    • TAKALA, J., KEINÄNEN, O., VÄISÄNEN, P. & KARI, A. (1989). Measurement of gas exchange in intensive care: Laboratory and clinical validation of a new device. Crit. Care Med., 17, 1041-1047.
    • (1989) Crit. Care Med. , vol.17 , pp. 1041-1047
    • Takala, J.1    Keinänen, O.2    Väisänen, P.3    Kari, A.4
  • 43
    • 0028799424 scopus 로고
    • The multiple organ dysfunction caused by endotoxin in the rat, attenuation of liver dysfunction by inhibitors of nitric oxide synthase
    • THIEMERMANN, C., RUETTEN, H., WU, C.C. & VANE, J.R. (1995). The multiple organ dysfunction caused by endotoxin in the rat, attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br. J. Pharmacol., 116, 2845-2851.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2845-2851
    • Thiemermann, C.1    Ruetten, H.2    Wu, C.C.3    Vane, J.R.4
  • 44
    • 0029560591 scopus 로고
    • Goal-directed therapy with dopexamine, dobutamine, and volume expansion: Effects of systemic oxygen transport on hepatic ultrastructure in porcine sepsis
    • TIGHE, D., MOSS, R., HEYWOOD, G., AL-SAADY, N., WEBB, A. & BENNETT, D. (1995). Goal-directed therapy with dopexamine, dobutamine, and volume expansion: effects of systemic oxygen transport on hepatic ultrastructure in porcine sepsis. Crit. Care Med., 23, 1997-2007.
    • (1995) Crit. Care Med. , vol.23 , pp. 1997-2007
    • Tighe, D.1    Moss, R.2    Heywood, G.3    Al-Saady, N.4    Webb, A.5    Bennett, D.6
  • 45
    • 0026652861 scopus 로고
    • Elevation of cardiac output and oxygen delivery improves outcome in septic shock
    • TUCHSCHMIDT, J., ERIED, J., ASTIZ, M. & RACKOW, E. (1992). Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest, 102, 216-220.
    • (1992) Chest , vol.102 , pp. 216-220
    • Tuchschmidt, J.1    Eried, J.2    Astiz, M.3    Rackow, E.4
  • 46
    • 0029041052 scopus 로고
    • Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock
    • VANDERMEER, T.J., WANG, H. & FINK, M.P. (1995). Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit. Care Med., 23, 1217-1226.
    • (1995) Crit. Care Med. , vol.23 , pp. 1217-1226
    • Vandermeer, T.J.1    Wang, H.2    Fink, M.P.3
  • 48
    • 0029932697 scopus 로고    scopus 로고
    • Prevention and therapy of multiple organ failure
    • VINCENT, J.L. (1996). Prevention and therapy of multiple organ failure. World J. Surg., 20, 465-470.
    • (1996) World J. Surg. , vol.20 , pp. 465-470
    • Vincent, J.L.1
  • 49
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure
    • On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
    • VINCENT, J.L, MORENO, R., TAKALA, J., WILLATTS, S., DE MENDONÇA, A., BRUINING, H., REINHART, C.K., SUTER, P.M. & THIJS L.G. (1996). The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med., 22, 707-710.
    • (1996) Intensive Care Med. , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3    Willatts, S.4    De Mendonça, A.5    Bruining, H.6    Reinhart, C.K.7    Suter, P.M.8    Thijs, L.G.9
  • 50
    • 0018964280 scopus 로고
    • Sepis and septic shock - A review of laboratory models and a proposal
    • WICHTERMAN, K.A., BAUE, A.E. & CHAUDRY, I.H. (1980). Sepis and septic shock - a review of laboratory models and a proposal. J. Surg. Res., 29, 189-201.
    • (1980) J. Surg. Res. , vol.29 , pp. 189-201
    • Wichterman, K.A.1    Baue, A.E.2    Chaudry, I.H.3
  • 52
    • 0017352154 scopus 로고
    • Glucose and lactate kinetics after endotoxin administration in dogs
    • WOLFE, R.R., ELAHI, D. & SPITZER, J.J. (1977). Glucose and lactate kinetics after endotoxin administration in dogs. Am J. Physiol., 232, E180-E185.
    • (1977) Am J. Physiol. , vol.232
    • Wolfe, R.R.1    Elahi, D.2    Spitzer, J.J.3
  • 53
    • 19244379884 scopus 로고
    • Glucose and lactate metabolism in experimental septic shock
    • WOLFE, R.R. & BURKE, J.F. (1978). Glucose and lactate metabolism in experimental septic shock. Am. J. Physiol., 235, R219-R227.
    • (1978) Am. J. Physiol. , vol.235
    • Wolfe, R.R.1    Burke, J.F.2
  • 54
    • 0019944770 scopus 로고
    • Stable isotope approaches for study of energy substrate metabolism
    • WOLFE, R.R. (1982). Stable isotope approaches for study of energy substrate metabolism. Fed. Proc., 41, 2692-2697.
    • (1982) Fed. Proc. , vol.41 , pp. 2692-2697
    • Wolfe, R.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.