Changes in KCNQ2 immunoreactivity in the amygdala in two rat models of temporal lobe epilepsy

Molecular Brain Research

Volumn 141, Issue 1, 2005, Pages 66-73

  Penschuck, Silke ^a   Bastlund, Jesper F ^a   Jensen, Henrik Sindal ^b   Stensbol, Tine Bryan ^b   Egebjerg, Jan ^b   Watson, William P ^a  

^a H LUNDBECK A S   (Denmark)

^b Department of Molecular Pharmacology ^*  (Denmark)

Author keywords

Amygdala; Immunoreactivity; KCNQ2; Kindling; Potassium channel; Spontaneous seizure

Indexed keywords

ANTIBODY; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN SUBUNIT;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROSTIMULATION; EPILEPTIC STATE; GRAND MAL SEIZURE; HIPPOCAMPUS; HYPOTHESIS; IMMUNOREACTIVITY; KINDLING; MALE; NONHUMAN; POTASSIUM CHANNEL KCNQ 2; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TEMPORAL LOBE EPILEPSY; UPREGULATION;

AMYGDALA; ANIMALS; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; HUMANS; IMMUNOHISTOCHEMISTRY; KCNQ2 POTASSIUM CHANNEL; KINDLING, NEUROLOGIC; MALE; RATS; RATS, WISTAR; UP-REGULATION;

ANIMALIA;

EID: 27644493331     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2005.08.004     Document Type: Article

References (42)

1. J.F. Bastlund, P. Jennum, P. Mohapel, and W.P. Watson Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry J. Neurosci. Methods 138 2004 65 72
2. C. Biervert, and O.K. Steinlein Structural and mutational analysis of KCNQ2, the major gene locus for benign familial neonatal convulsions Hum. Genet. 104 1999 234 240
3. C. Biervert, B.C. Schroeder, C. Kubisch, S.F. Berkovic, P. Propping, T.J. Jentsch, and O.K. Steinlein A potassium channel mutation in neonatal human epilepsy Science 279 1998 403 406
4. R. Borgatti, C. Zucca, A. Cavallini, M. Ferrario, C. Panzeri, P. Castaldo, M.V. Soldovieri, C. Baschirotto, N. Bresolin, B.B. Dalla, M. Taglialatela, and M.T. Bassi A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation Neurology 63 2004 57 65
5. C. Brandt, M. Glien, H. Potschka, H. Volk, and W. Loscher Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats Epilepsy Res. 55 2003 83 103
6. D.P. Cain Kindling and the amygdala The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction 1992 Wiley-Liss Inc. New York 539 560
7. E.C. Cooper, E. Harrington, Y.N. Jan, and L.Y. Jan M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain J. Neurosci. 21 2001 9529 9540
8. + channel J. Neurosci. 24 2004 1236 1244
9. W.E. Fieles, J. Smith, E. Christian, E. Johnson, A. Cross, and L. Mrzljak Distribution of KCNQ2 and KCNQ3 Potassium Channel Subunits in the Macaque Monkey Brain Soc. Neurosci. Abstr. 27 2001
10. P. Gloor Role of the amygdala in temporal lobe epilepsy The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction 2005 Wiley-Liss Inc. New York 505 538
11. T.J. Jentsch Neuronal KCNQ potassium channels: physiology and role in disease Nat. Rev., Neurosci. 1 2000 21 30
12. W. Loscher Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy Epilepsy Res. 50 2002 105 123
13. E.W. Lothman, E.H. Bertram, J.W. Bekenstein, and J.B. Perlin Self-sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation: electrographic and behavioral characteristics Epilepsy Res. 3 1989 107 119
14. E.W. Lothman, E.H. Bertram, J. Kapur, and J.L. Stringer Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus Epilepsy Res. 6 1990 110 118
15. N.V. Marrion Control of M-current Annu. Rev. Physiol. 59 1997 483 504
16. M. Martire, P. Castaldo, M. D'Amico, P. Preziosi, L. Annunziato, and M. Taglialatela M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals J. Neurosci. 24 2004 592 597
17. P. Mohapel, C.T. Ekdahl, and O. Lindvall Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus Neurobiol. Dis. 15 2004 196 205
18. K. Morimoto, M. Fahnestock, and R.J. Racine Kindling and status epilepticus models of epilepsy: rewiring the brain Prog. Neurobiol. 73 2004 1 60
19. M. Nakamura, H. Watanabe, Y. Kubo, M. Yokoyama, T. Matsumoto, H. Sasai, and Y. Nishi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels Recept. Channels 5 1998 255 271
20. M. Niittykoski, J. Nissinen, M. Penttonen, and A. Pitkanen Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats Neuroscience 124 2004 269 281
21. J. Nissinen, T. Halonen, E. Koivisto, and A. Pitkanen A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat Epilepsy Res. 38 2000 177 205
22. J.F. Otto, Y. Yang, W.N. Frankel, K.S. Wilcox, and H.S. White Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel Epilepsia 45 2004 1009 1016
23. Z. Pan, A.A. Selyanko, J.K. Hadley, D.A. Brown, J.E. Dixon, and D. McKinnon Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents J. Physiol. 531 2001 347 358
24. H.C. Pape, and R.B. Driesang Ionic mechanisms of intrinsic oscillations in neurons of the basolateral amygdaloid complex J. Neurophysiol. 79 1998 217 226
25. S. Pereira, P. Roll, J. Krizova, P. Genton, M. Brazdil, R. Kuba, P. Cau, I. Rektor, and P. Szepetowski Complete loss of the cytoplasmic carboxyl terminus of the KCNQ2 potassium channel: a novel mutation in a large Czech pedigree with benign neonatal convulsions or other epileptic phenotypes Epilepsia 45 2004 384 390
26. H.C. Peters, H. Hu, O. Pongs, J.F. Storm, and D. Isbrandt Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior Nat. Neurosci. 8 2005 51 60
27. R.J. Racine Modification of seizure activity by electrical stimulation: II. Motor seizure Electroencephalogr. Clin. Neurophysiol. 32 1972 281 294
28. M.C. Richards, S.E. Heron, H.E. Spendlove, I.E. Scheffer, B. Grinton, S.F. Berkovic, J.C. Mulley, and A. Davy Novel mutations in the KCNQ2 gene link epilepsy to a dysfunction of the KCNQ2-calmodulin interaction J. Med. Genet. 41 2004 e35
29. + channels Br. J. Pharmacol. 137 2002 1173 1186
30. G.M. Ronen, T.O. Rosales, M. Connolly, V.E. Anderson, and M. Leppert Seizure characteristics in chromosome 20 benign familial neonatal convulsions Neurology 43 1993 1355 1360
31. A. Rostock, C. Tober, C. Rundfeldt, R. Bartsch, J. Engel, E.E. Polymeropoulos, B. Kutscher, W. Loscher, D. Honack, H.S. White, and H.H. Wolf D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures Epilepsy Res. 23 1996 211 223
32. + channels causes epilepsy Nature 396 1998 687 690
33. J.S. Smith, C.A. Iannotti, P. Dargis, E.P. Christian, and J. Aiyar Differential expression of kcnq2 splice variants: implications to m current function during neuronal development J. Neurosci. 21 2001 1096 1103
34. P. Somogyi, and H. Takagi A note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry Neuroscience 7 1982 1779 1783
35. O.K. Steinlein, J. Stoodt, C. Biervert, D. Janz, and T. Sander The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy NeuroReport 10 1999 1163 1166
36. B. Tang, H. Li, K. Xia, H. Jiang, Q. Pan, L. Shen, Z. Long, G. Zhao, and F. Cai A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family J. Neurol. Sci. 221 2004 31 34
37. C. Tober, A. Rostock, C. Rundfeldt, and R. Bartsch D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures Eur. J. Pharmacol. 303 1996 163 169
38. H.S. Wang, Z. Pan, W. Shi, B.S. Brown, R.S. Wymore, I.S. Cohen, J.E. Dixon, and D. McKinnon KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel Science 282 1998 1890 1893
39. H. Watanabe, E. Nagata, A. Kosakai, M. Nakamura, M. Yokoyama, K. Tanaka, and H. Sasai Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability J. Neurochem. 75 2000 28 33
40. Y.J. Wu, C.G. Boissard, J. Chen, W. Fitzpatrick, Q. Gao, V.K. Gribkoff, D.G. Harden, H. He, R.J. Knox, J. Natale, R.L. Pieschl, J.E. Starrett Jr., L.Q. Sun, M. Thompson, D. Weaver, D. Wu, and S.I. Dworetzky (S)-N-[1-(4- cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons Bioorg. Med. Chem. Lett. 14 2004 1991 1995
41. C. Yue, and Y. Yaari KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons J. Neurosci. 24 2004 4614 4624
42. E. Yus-Najera, A. Munoz, N. Salvador, B.S. Jensen, H.B. Rasmussen, J. Defelipe, and A. Villarroel Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation Neuroscience 120 2003 353 364