Rac3-mediated transformation requires multiple effector pathways

Cancer Research

Volumn 65, Issue 21, 2005, Pages 9883-9890

  Keller, Patricia J ^a   Gable, Christyn M ^b   Wing, Michele R ^a   Cox, Adrienne D ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; CYCLIN D1; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE; LUCIFERASE; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE 2; MIXED LINEAGE KINASE 3; MUTANT PROTEIN; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA2; RAC PROTEIN; RAC1 PROTEIN; RAC3 PROTEIN; SERUM RESPONSE FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; BINDING ASSAY; CANCER GROWTH; CELL ASSAY; CELL TRANSFORMATION; CONTROLLED STUDY; EFFECTOR DOMAIN MUTANT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; INDUCED MUTATION; MEMBRANE RUFFLING; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; CARRIER PROTEINS; CELL ADHESION; CELL GROWTH PROCESSES; CELL TRANSFORMATION, NEOPLASTIC; CERCOPITHECUS AETHIOPS; COS CELLS; ISOENZYMES; MICE; NEUROPEPTIDES; NIH 3T3 CELLS; PHOSPHOLIPASE C; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; SERUM RESPONSE FACTOR; TRANS-ACTIVATION (GENETICS);

EID: 27544475993     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3116     Document Type: Article

References (54)

1. Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004;116:167-79.
2. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 2000;348 Pt 2:241-55.
3. Cotteret S, Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol 2002;3:REVIEWS0002.
4. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998;279:509-14.
5. Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002;2:133-42.
6. Hill CS, Wynne J, Treisman R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 1995;81:1159-70.
7. 1 cell cycle regulation. Breast Cancer Res Treat 2004;84:33-42.
8. Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC. Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins. Genes Dev 1997;11:463-75.
9. Coniglio SJ, Jou TS, Symons M. Rac1 protects epithelial cells against anoikis. J Biol Chem 2001;276:28113-20.
10. Ruggieri R, Chuang YY, Symons M. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Mol Med 2001;7:293-300.
11. van Leeuwen FN, van der Kammen RA, Habets GG, Collard JG. Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells. Oncogene 1995;11:2215-21.
12. Westwick JK, Lambert QT, Clark GJ, et al. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol 1997;17:1324-35.
13. Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol 1995;15:6443-53.
14. Qiu RG, Chen J, Kim D, McCormick F, Symons M. An essential role for Rac in Ras transformation. Nature 1995;374:457-9.
15. Schmitz AA, Govek EE, Bottner B, Van Aelst L. Rho GTPases: signaling, migration, and invasion. Exp Cell Res 2000;261:1-12.
16. Joyce PL, Cox AD. Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. Cancer Res 2003;63:7959-67.
17. Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A 2004;101:7618-23.
18. Haataja L, Groffen J, Heisterkamp N. Characterization of RAC3, a novel member of the Rho family. J Biol Chem 1997;272:20384-8.
19. Malosio ML, Gilardelli D, Paris S, Albertinazzi C, de Curtis I. Differential expression of distinct members of Rho family GTP-binding proteins during neuronal development: identification of Rac1B, a new neural-specific member of the family. J Neurosci 1997;17:6717-28.
20. Courjal F, Chuchana P, Theillet C, Fort P. Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. Genomics 1997;44:242-6.
21. Mira JP, Benard V, Groffen J, Sanders LC, Knaus UG. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A 2000;97:185-9.
22. Cho YJ, Zhang B, Kaartinen V, et al. Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol 2005;25:5777-85.
23. 2 as an effector site for Rac. J Biol Chem 2003;278:21099-104.
24. White MA, Nicolette C, Minden A, et al. Multiple Ras functions can contribute to mammalian cell transformation. Cell 1995;80:533-41.
25. Khosravi-Far R, White MA, Westwick JK, et al. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol 1996;16:3923-33.
26. Zohar M, Teramoto H, Katz BZ, Yamada KM, Gutkind JS. Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation. Oncogene 1998;17:991-8.
27. Fiordalisi JJ, Johnson RL II, Ulku AS, Der CJ, Cox AD. Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods Enzymol 2001;332:3-36.
28. Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ. RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem 2002;277:47810-7.
29. Karnoub AE, Der CJ, Campbell SL. The insert region of Rac1 is essential for membrane ruffling but not cellular transformation. Mol Cell Biol 2001;21:2847-57.
30. Brown HA, Lazarowski ER, Boucher RC, Harden TK. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells. Mol Pharmacol 1991;40:648-55.
31. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 1996;87:519-29.
32. Jonespn T, McDonough M, Bar-Sagi D, Van Aelst L. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 1996;274:1374-6.
33. Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 2003;72:743-81.
34. Kim SK. Cell polarity: new PARtners for Cdc42 and Rac. Nat Cell Biol 2000;2:E143-5.
35. Owen D, Mott HR, Laue ED, Lowe PN. Residues in Cdc42 that specify binding to individual CRIB effector proteins. Biochemistry 2000;39:1243-50.
36. Henrique D, Schweisguth F. Cell polarity: the ups and downs of the Par6/aPKC complex. Curr Opin Genet Dev 2003;13:341-50.
37. Nagata K, Puls A, Futter C, et al. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J 1998;17:149-58.
38. Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem 1996;271:27225-8.
39. Illenberger D, Walliser C, Nurnberg B, Diaz Lorente M, Gierschik P. Specificity and structural requirements of phospholipase C-β stimulation by Rho GTPases versus G protein β γ dimers. J Biol Chem 2003;278:3006-14.
40. Freeman JL, Abo A, Lambeth JD. Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J Biol Chem 1996;271:19794-801.
41. Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH. Structural requirements for PAK activation by Rac GTPases. J Biol Chem 1998;273:21512-8.
42. van Hennik PB, ten Klooster JP, Halstead JR, et al. The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem 2003;278:39166-75.
43. Burbelo PD, Drechsel D, Hall A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 1995;270:29071-4.
44. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol 1996;6:598-605.
45. Fanger GR, Johnson NL, Johnson GL. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J 1997;16:4961-72.
46. Tapon N, Nagata K, Lamarche N, Hall A. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways. EMBO J 1998;17:1395-404.
47. Buchsbaum RJ, Connolly BA, Feig LA. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol Cell Biol 2002;22:4073-85.
48. Singer WD, Brown HA, Sternweis PC. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Annu Rev Biochem 1997;66:475-509.
49. 2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cβ3 on 537-Ser. Mol Cell Endocrinol 2001;175:149-56.
50. 2+/calmodulin-dependent kinase. Mol Cell Biol 1995;15:3672-84.
51. Davis FJ, Gupta M, Camoretti-Mercado B, Schwartz RJ, Gupta MP. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy. J Biol Chem 2003;278:20047-58.
52. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001;411:1017-21.
53. 2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J Biol Chem 1998;273:16739-47.
54. Rodriguez-Puebla ML, Robles AI, Conti CJ. ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development. Mol Carcinog 1999;24:1-6.