Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition

Biochemical and Biophysical Research Communications

Volumn 338, Issue 1, 2005, Pages 206-214

  Neidig, Michael L ^a   Decker, Andrea ^a   Kavana, Michael ^b   Moran, Graham R ^b   Solomon, Edward I ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Ketoglutarate dioxygenases; (4 Hydroxyphenyl)pyruvate dioxygenase; Density function theory; Drug inhibition; Magnetic circular dichroism; Non heme iron; Structure activity relationships

Indexed keywords

(4 HYDROXYPHENYL)PYRUVATE DIOXYGENASE; (4 HYDROXYPHENYL)PYRUVATE DIOXYGENASE INHIBITOR; [2 NITRO 4 (TRIFLUOROMETHYL)BENZOYL] 1,3 CYCLOHEXANEDIONE; NONHEME IRON PROTEIN; OXYGENASE; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ALKAPTONURIA; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CATALYSIS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY; DENSITY FUNCTIONAL THEORY; DISEASE CLASSIFICATION; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TREATMENT INDICATION; TYROSINEMIA;

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; BINDING SITES; CATALYTIC DOMAIN; CIRCULAR DICHROISM; COMPUTATIONAL BIOLOGY; CYCLOHEXANONES; ENZYME INHIBITORS; IRON; STREPTOMYCES; THERMODYNAMICS;

EID: 27544447429     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.242     Document Type: Article

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